Xadago (Safinamide Methansulfonate)

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Xadago Brand
Dosage Quantity & Price
Safinamide Methansulfonate (Generic alternate to Xadago) Generic

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Xadago (generically known as safinamide) is a prescription medication indicated to treat symptoms of Parkinson's disease. It can help improve symptoms such as shakiness, stiffness, and difficulty moving. It is given with levodopa and carbidopa to treat "wearing-off" episodes (muscle stiffness, loss of muscle control) in people with Parkinson's disease.

Safinamide belongs to a class of drugs known monoamine oxidase type B (MAO-B) inhibitor and works by blocking an enzyme in the brain that breaks down dopamine, a substance that helps regulate movement in the body. It works by increasing the levels of certain natural substances in the brain (such as dopamine). Parkinson's disease is thought to be caused by too little dopamine in the brain.

Uses and Dosage

Xadago is typically taken in tablet form by mouth, either with or without food as directed by your doctor, usually once daily. The dosage is based on your medical condition and how you respond to treatment. Do not increase your dose or take it more often than prescribed, as doing so will not improve your condition any faster and may increase your risk of side effects.

To get the most benefit from Xadago, take it regularly and at the same time each day. Do not stop taking this medication without consulting your doctor, as some conditions may worsen if the drug is stopped suddenly. Your doctor may gradually decrease your dose if necessary.

Eating a large amount of tyramine while taking safinamide, and for 2 weeks after stopping it, may cause a rare, but serious, high blood pressure reaction. Patients should avoid consuming foods high in tyramine, such as aged cheeses like Stilton cheese, and consult their doctor or dietician about which other foods to avoid. If feeling unwell after eating or drinking certain foods while taking this medication, seek medical advice. See also the Side Effects section for further information.

Side effect

Common Side Effects of Xadago (Safinamide Methansulfonate):

  • Uncontrolled, sudden movements (dyskinesia)
  • Falls
  • Nausea
  • Trouble sleeping or falling asleep (insomnia)

Serious Side Effects of Xadago (Safinamide Methansulfonate):

  • High blood pressure (hypertension)
  • Symptoms of serotonin syndrome may include:
  • Agitation, hallucinations, coma, or other changes in mental status
  • High or low blood pressure
  • Seizures
  • Problems controlling your movements or muscle twitching
  • Sweating or fever
  • Nausea or vomiting
  • Fast heartbeat
  • Muscle stiffness or tightness
  • Diarrhea
  • Falling asleep during normal activities
  • Uncontrolled, sudden movements (dyskinesia)
  • Hallucinations and other psychosis
  • Unusual urges
  • Problems with the retina in your eye (retinal changes)

Form and strength

Xadago (Safinamide Methansulfonate) is available in the following forms and strength:

Xadago: Tablet

  • 50 mg
  • 100 mg


  • Blood pressure changes: Xadago may increase blood pressure, so patients should have their blood pressure monitored regularly.
  • Serotonin syndrome: Xadago may increase serotonin levels in the brain, which can lead to a potentially life-threatening condition called serotonin syndrome. Symptoms include fever, agitation, confusion, tremors, and muscle rigidity.
  • Hallucinations and psychotic behavior: Xadago may cause hallucinations and psychotic behavior in some patients, particularly those with a history of psychiatric disorders.
  • Impulse control disorders: Xadago may cause impulse control disorders, such as compulsive gambling or hypersexuality, in some patients.
  • Withdrawal symptoms: Patients who stop taking Xadago suddenly may experience withdrawal symptoms such as fever, confusion, and muscle stiffness, so the medication should be tapered off slowly under medical supervision.
  • Hepatic impairment: Xadago should be used with caution in patients with moderate to severe liver impairment.
  • Renal impairment: Xadago should be used with caution in patients with moderate to severe kidney impairment.
  • Pregnancy and breastfeeding: The safety of Xadago in pregnant and breastfeeding women has not been established, and the medication should only be used if the potential benefit justifies the potential risk to the fetus or infant.
  • Drug interactions: Xadago may interact with certain medications, such as antidepressants, opioids, and other medications that increase serotonin levels in the brain. Patients should tell their healthcare provider about all medications they are taking before starting Xadago.

Frequently Asked Questions (FAQ)

When is the best time to take Xadago?

Xadago is taken once a day, usually in the morning

How long does it take for Xadago to start working?

Xadago may take a few weeks to reach its full effect, so patients should continue to take it as directed by their healthcare provider.

What should I do if I miss a dose of Xadago?

If a dose of Xadago is missed, patients should take the missed dose as soon as they remember. If it is close to the time of the next dose, they should skip the missed dose and continue with their regular dosing schedule.

Can Xadago be given to children?

The safety and effectiveness of Xadago in children has not been established, so do not use it in children under the age of 18.


It's important to purchase Xadago from verified Canadian pharmacy.

Additional information

Generic name:

Safinamide Methansulfonate




50mg, 100mg

Quantities Available: