Depakene (Valproic Acid)

Indications

Depakene is a medication used to treat certain types of seizure disorders, including simple and complex absence seizures. It may also be used as an adjunctive therapy in the treatment of other seizure disorders and bipolar disorder.

Depakene uses the active ingredient valproic acid, belonging to a class of drugs known as anti-epileptic drugs, or AEDs (antiepileptic drugs). Depakene works by restoring the balance of certain natural substances (neurotransmitters) in the brain.

Uses and Dosage

Depakene (valproic acid) is available in the form of a delayed-release capsule. It should be taken by mouth as directed by your healthcare provider. In case of stomach upset, the capsule may be taken with food. However, the capsule should be swallowed whole and not crushed or chewed, which can irritate the mouth or throat.

The dosage of the medication will depend on several factors such as your age, weight, medical condition, response to treatment, and other medications you may be taking. You should inform your healthcare provider about all the products you use, including prescription drugs, nonprescription drugs, and herbal products.

If Depakene is used for seizures, do not stop taking it without consulting your healthcare provider. Suddenly stopping the medication can make your condition worse.

Side effect

Common Side Effects of Depakene (Valproic Acid):

• Drowsiness
• Dizziness
• Headaches
• Nausea
• Vomiting
• Indigestion
• Fatigue
• Somnolence
• Weight gain

Serious Side Effects of Depakene (Valproic Acid):

• Depression
• Anxiety
• Mood changes
• Increase in seizures
• Hallucinations
• Sudden urination
• Hypothermia
• Abdominal pain
• Rapid heartbeat
• Severe flu-like symptoms
• Hyperammonemia (High ammonia levels in the bloodstream): fatigue, weakness, irritability, appetite changes, mood changes
• Hypothermia: shivers, slurred speech, weak pulse, confusion, shortness of breath.
• Kidney problems: nausea, vomiting, increased thirst, blood in urine, edema, dark urine, jaundice
• Liver disease: Itchy skin, nausea, loss of appetite, dark urine, jaundice

Form and Strength

Depakene (Valproic Acid) is available in the following forms and strength:

Valproic Acid: Delayed Release Capsule

• 250 mg
• 500 mg

Caution

• Depakene should not be taken by patients who are allergic to valproic acid or any of the ingredients in the medication. Patients with liver problems or certain genetic conditions may also not be able to take Depakene. Consult with your healthcare provider to determine if Depakene is appropriate for you.
• Depakene may not be safe to take during pregnancy, as it can increase the risk of birth defects in the baby. Pregnant women or women who are planning to become pregnant should consult with their healthcare provider before taking Depakene.
• Depakene can increase the risk of birth defects if taken during pregnancy. Pregnant women or women who are planning to become pregnant should speak with their healthcare provider before taking Depakene.
• Depakene can cause liver problems, which can be serious or life-threatening. Have regular blood tests to monitor liver function while taking Depakene.
• Depakene can also cause inflammation of the pancreas, which can be serious or life-threatening. Symptoms of pancreatitis may include severe stomach pain that does not go away.
• Depakene can interact with other medications, inform your healthcare provider of all medications you are taking before starting Depakene treatment.
• Depakene can cause elevated levels of ammonia in the blood, which can be especially dangerous for those with certain metabolic disorders or liver problems. Regular blood tests may be necessary to monitor ammonia levels.
• Depakene may cause a decrease in the number of platelets in the blood, which can increase the risk of bleeding or bruising. Platelet counts should be monitored regularly.
• Depakene may cause cognitive or behavioral effects, including memory problems, confusion, and changes in mood or behavior. Patients should report any changes to their healthcare provider.
• Depakene has been associated with a decrease in bone density or osteoporosis, which can increase the risk of fractures. Patients should discuss any concerns about bone health with their healthcare provider.

Frequently Asked Questions (FAQ)

Does Depakene have any drug interactions?

Yes, Depakene may interact with other medications. Inform your healthcare provider of all medications you are taking before starting Depakene treatment.

Can Depakene cause weight gain?

Yes, weight gain can be a side effect of Depakene. Maintain a healthy diet and exercise regularly while taking the medication.

Can Depakene be taken with food?

Depakene can be taken with or without food. If the medication causes stomach upset, taking it with food or milk may help.

Can Depakene be taken for long periods of time?

Depakene can be taken for extended periods of time, as directed by your healthcare provider. Follow the recommended dosage and do not exceed the duration of treatment prescribed by your healthcare provider.

Can Depakene be stopped suddenly?

Depakene should not be stopped suddenly, as this can cause withdrawal symptoms. Gradually reduce the dosage of the medication under the guidance of your healthcare provider.

Resources

• https://www.rxlist.com/depakene-drug.htm
• https://www.webmd.com/drugs/2/drug-9702-19/depakene-oral/valproic-acid-oral/details
• https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/018081s071,018082s054lbl.pdf
• https://www.medbroadcast.com/drug/getdrug/depakene
• https://clincalc.com/PronounceTop200Drugs/HowToPronounce/valproicacid