Propylthyracil (Propylthiouracil) Shopper Approved

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Propylthyracil is a medication used to treat certain medical conditions, primarily autoimmune diseases such as rheumatoid arthritis. It belongs to a class of drugs known as immune-suppressants as anti-thyroid agent. PTU works by decreasing the amount of thyroid hormones produced in the body, which can reduce symptoms such as rapid heart rate, sweating, and weight loss.

Propylthiouracil (PTU) is a prescription drug used to treat hyperthyroidism, a condition where the thyroid gland produces too much thyroid hormone. It is a medication used to treat certain conditions in adults, such as hyperthyroidism, Grave's disease, and thyroid cancer. It is a common choice for treating thyroid disorders due to its low cost and effectiveness in managing symptoms.

Uses and Dosage

Take Propylthiouracil tablets by mouth as directed by your doctor. Usually, it is taken three times a day, every eight hours. Carefully follow the directions on your prescription label and ask your doctor or pharmacist to explain any part that you do not understand. Take Propylthiouracil exactly as directed, without taking more or less of it or taking it more often than prescribed by your doctor. Once your condition is under control, your doctor may decrease your dose of Propylthiouracil. Even if you feel well, continue to take the medication, and do not stop taking it without talking to your doctor.

The usual adult starting dose of propylthiouracil is 50 mg to 100 mg every 8 hours, with increases as necessary up to a maximum of 500 mg daily or as directed by your doctor. When doses larger than 300 mg per day are needed, the medication should be taken every 4 to 6 hours. Children's doses are based on their body weight.

Side Effect

Common Side Effects of Propylthyracil (Propylthiouracil):

  • Dizziness
  • Drowsiness
  • Headache
  • Muscle aches
  • Nausea
  • Stomach pain
  • Vomiting

Serious Side Effects of Propylthyracil (Propylthiouracil):

  • Backache
  • Numbness or tingling of fingers, toes, or face
  • Pain, swelling, or redness in joints
  • Signs of clotting problems
    • Bleeding gums
    • Blood in urine
    • Bruising
    • Coughing blood
    • Cuts that do not stop bleeding)
    • Unusual nosebleeds
  • Signs of infection
    • Fever or chills
    • Headache, stiff neck
    • Listlessness
    • Prolonged dizziness
    • Severe diarrhea
  • Shortness of breath
    • Blood in the urine
    • Change of urine color
    • Decreased urine production
    • Increased urination at night
    • Signs of kidney problems
    • Skin rash
    • Swelling of feet or lower legs
    • Weight loss
  • Symptoms of liver problems
    • Abdominal pain
    • Dark urine
    • Fatigue
    • Itching
    • Nausea
    • Pale stools
    • Yellow eyes or skin

Form and Strength

Propylthyracil (Propylthiouracil) is available in the following forms and strength:

Propylthiouracil: Tablet

  • 50 mg


  • If you are starting to use propylthiouracil, let your doctor know about any medical conditions or allergies you may have, as well as any medications you are currently taking.
  • If you are taking propylthiouracil, it may lead to a reduction in the number of neutrophils, red blood cells, and platelets in your blood. As a precaution, if you experience any symptoms of infection such as fever, chills, sore throat or abnormal bleeding or bruising, you should immediately contact your physician.
  • Your dose of propylthiouracil will be reduced or temporarily discontinued by your doctor if signs of hypothyroidism (such as weight gain, clumsiness, and intolerance of cold temperatures) occur during treatment.
  • Discuss with your physician if you have kidney problems, particularly regarding the potential effects that propylthiouracil may have on your medical condition, the suitability of the dosage and how effective the medication may be for you. Your doctor may also want to monitor you more closely during treatment to ensure safety and effectiveness of the medication.
  • Propylthiouracil should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking propylthiouracil, contact your doctor immediately. Women who may become pregnant should use effective birth control while taking propylthiouracil.
  • If you have liver problems, discuss with your doctor how it may affect your medical condition, how your medical condition may affect the dosing and effectiveness of propylthiouracil, and whether any special monitoring is needed.

Frequently Asked Questions (FAQ)

How does propylthiouracil work?

PTU works by inhibiting the production of thyroid hormones in the thyroid gland.

Is propylthiouracil safe to use during pregnancy and breastfeeding?

Propylthiouracil is considered safe to use during pregnancy and breastfeeding, but it is important to talk to your doctor before taking any medication.

Can I take propylthiouracil if I have kidney problems?

If you have kidney problems, it is important to discuss with your doctor how propylthiouracil may affect your medical condition and whether any special monitoring is needed.

How long does it take for propylthiouracil to work?

The onset of action of propylthiouracil varies from person to person, with some patients experiencing improvement within a few days, while it may take up to a few weeks for others.


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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Propylthyracil (Propylthiouracil). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Propylthyracil (Propylthiouracil).