Indications
Sensipar (active ingredient: cinacalcet) is a prescription medication indicated for the following:
- Secondary Hyperparathyroidism: Sensipar is used for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease (CKD) on dialysis.
- Hypercalcemia in Parathyroid Carcinoma: It is also indicated for the treatment of hypercalcemia in patients with parathyroid carcinoma.
- Hypercalcemia in Primary Hyperparathyroidism: Sensipar is used for the treatment of hypercalcemia in patients with primary hyperparathyroidism who are unable to undergo parathyroidectomy.
Sensipar belongs to a class of drugs known as calcimimetics, which work by increasing the sensitivity of the calcium-sensing receptors on the parathyroid gland, leading to decreased parathyroid hormone (PTH) secretion and subsequently lowering serum calcium levels.
Uses and Dosage
Sensipar tablets should be taken with food and may be taken with or without water. They should be swallowed whole and not crushed or chewed. Take Sensipar exactly as prescribed by your healthcare provider, and avoid crushing, chewing, or breaking the tablet.
Sensipar is normally dosed at 30 mg by mouth once or twice daily depending on the cause of your high parathyroid hormone levels. Your healthcare provider will let you know how to take the medication and will monitor your blood levels to make appropriate adjustments to your dose.
Side Effects
Common Side Effects of Sensipar (Cinacalcet HCL):
- Decrease appetite
- Diarrhea
- Dizziness
- Low calcium levels
- Nausea
- Vomiting
Serious Side Effects of Sensipar (Cinacalcet HCL):
- Bloody or tarry stools
- Coughing up blood
- Difficulty breathing
- Fast or slow heart rate
- Hives
- Muscle pain, tightness, or contraction
- Numbness or tingly feeling around the mouth
- Overactive reflexes
- Rapid weight gain
- Seizure
- Shortness of breath
- Swelling of the face, lips, tongue, or throat
- Vomit that looks like coffee grounds
Form and Strength
Sensipar (Cinacalcet HCL) is available in the following forms and strengths:
Sensipar: Tablet
- 30 mg
- 60 mg
- 90 mg
Cinacalcet HCL: Tablet
- 30 mg
Caution
- Sensipar is contraindicated in patients with a history of hypersensitivity to cinacalcet or any of its components, as well as in patients with hypocalcemia.
- Cinacalcet can increase the risk of seizures, particularly in patients with a history of seizures.
- There have been reports of GI bleeding in patients taking cinacalcet. Patients should report any signs of bleeding to their healthcare provider.
- Cinacalcet can cause low levels of calcium in the blood, which can be dangerous. Monitor calcium levels during treatment.
- Consult with a healthcare professional before starting treatment with Sensipar, as they can provide guidance on proper dosages, potential side effects, and any other relevant factors that may impact the effectiveness and safety of the medication.
- Cinacalcet can cause a decrease in blood pressure, which may be more likely to occur in patients with congestive heart failure or other cardiovascular disease.
- Cinacalcet should be used with caution in patients with impaired liver function.
- There is limited information about the use of cinacalcet in pregnant and breastfeeding women. Consult with your healthcare provider before taking cinacalcet if you are pregnant or breastfeeding.
Frequently Asked Questions (FAQ)
How does Sensipar work?
Sensipar works by increasing the sensitivity of the calcium-sensing receptors in the parathyroid gland, resulting in a reduction of parathyroid hormone (PTH) levels.
Can Sensipar be taken with other medications?
There may be interactions between Sensipar and other medications. Talk to your healthcare provider about any medications or supplements you are taking before starting Sensipar.
How long does it take for cinacalcet to work?
The effects of cinacalcet may not be seen for several weeks to several months, depending on the individual patient's response and dosage.
Can cinacalcet be taken with other medications?
Tell your healthcare provider about all medications you are currently taking, including prescription, over-the-counter, and herbal supplements. They can help determine if cinacalcet is safe to take with your other medications.
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