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Lamictal

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Prescription Prescription Required FormationFormulation: Tablet

Lamotrigine

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Lamictal, also known by its generic name Lamotrigine, is a medication used to treat epilepsy and bipolar disorder. It is also used for unipolar depression and to prevent migraine headaches. It is an anticonvulsant, meaning it works to reduce the frequency and intensity of seizures, as well as stabilize mood swings associated with bipolar disorder.

Lamictal (Lamotrigine) is a prescription medication used in the treatment of mental health conditions such as epilepsy and bipolar disorder. Lamotrigine has been found to be effective in the off-label treatment of rapid-cycling bipolar depression, bipolar disorder type I maintenance, and prophylaxis for basilar migraine with aura, panic disorder, and binge eating disorder.

Lamotrigine is an antiepileptic drug that has been approved by the United States Food and Drug Administration (FDA) for the treatment of primary generalized tonic-clonic seizures, including simple and complex partial seizures and focal-onset tonic-clonic seizures, as well as Lennox-Gastaut Syndrome.

Lamotrigine is available as orally disintegrating tablets in 25 mg, 50 mg, 100 mg, and 200 mg strength. When administering lamotrigine, special consideration should be taken if used in conjunction with drugs such as carbamazepine, phenytoin, phenobarbital, primidone, rifampin, lopinavir/ritonavir, atazanavir, ritonavir, and valproic acid, as dose adjustment may be necessary.

Lamictal doses depend on the condition being treated and on whether it is used alone or in combination with other antiseizure medications.

  • For Seizures patients not concurrently taking carbamazepine, phenytoin, phenobarbital, primidone, rifampin, lopinavir/ritonavir, atazanavir, ritonavir, or valproic acid, Lamotrigine should be administered at a dose of 25 mg daily for the first week. At week three, the dose should be increased to 50 mg per day, and at week five, it should be increased by an additional 50 mg each week or every other week until a typical maintenance dose of 225 mg to 375 mg daily in two divided doses is reached.
  • When Lamotrigine is used concurrently with valproic acid, dosing instructions should be followed accordingly in case of Seizures treatment. Initially, the dose should be set at 25 mg every other day. At week three, the dose should be increased to 25 mg daily. At week five, the dose should be increased by an additional 25 mg per week or every other week. The typical maintenance dose for use with valproic acid alone is 100 mg to 200 mg daily in one or two divided doses, while when used with medications that induce glucuronidation, the typical maintenance dose is 100 mg to 400 mg daily in one or two divided doses.
  • When using Lamotrigine in combination with carbamazepine, phenytoin, phenobarbital, primidone, rifampin, lopinavir/ritonavir, atazanavir, or ritonavir to treat Seizures, the following dosing instructions should be followed. Initially, the dosage should be 50 mg given daily. At the third week, the dosage should be increased to 100 mg per day in two separate doses. At the fifth week, it should be increased by an additional 100 mg each week or every other week. The typical maintenance dosage ranges from 300 mg to 500 mg in two separate doses.
  • The recommended dosage of Lamictal (Lamotrigine) for bipolar 1 disorder is 200-400 mg per day, divided into two doses. For people with hepatic disease, the recommended dosage is 50-200 mg per day, divided into two doses. It is important to consult with a healthcare provider before starting or changing the dosage of Lamictal, as the dosage may need to be adjusted based on individual factors.

Lamictal May Cause Serious Side Effects Including:

  • Any skin rash, especially with blistering and peeling
  • Painful sores in your mouth or around your eyes
  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out
  • Severe headache
  • Confusion
  • Slurred speech
  • Arm or leg weakness
  • Trouble walking
  • Loss of coordination
  • Feeling unsteady
  • Very stiff muscles
  • High fever
  • Profuse sweating
  • Tremors
  • Unusual bleeding
  • Yellowing of the skin or eyes (jaundice)

The Most Common Side Effects of Lamictal Include:

  • Nausea or vomiting
  • Chest or back pain
  • Xerostomia
  • Edema
  • Dysmenorrhea
  • Weight changes
  • Constipation
  • Abdominal pain
  • Pain or weakness
  • Insomnia or drowsiness
  • Dizziness
  • Ataxia
  • Diplopia
  • Headache
  • Anxiety or irritability
  • Visual disturbances

Lamictal and its generic alternative Lamotrigine are available in the following forms and strengths:

Lamictal Tablet

  • 25 mg
  • 50 mg
  • 100 mg
  • 150 mg
  • 200 mg

Lamotrigine Tablet

  • 25 mg
  • 50 mg
  • 100 mg
  • 150 mg
  • 200 mg

When taking Lamictal (Lamotrigine), it is important to be aware of the following cautions:

  • Lamictal can cause severe skin rashes and other serious skin reactions, so it is important to contact your healthcare provider if you experience any skin reactions.
  • Lamictal may cause liver problems, so it is important to get regular blood tests to monitor your liver function.
  • Lamictal can cause a decrease in white blood cells, so it is important to have regular blood tests to monitor your white blood cell count.
  • Lamictal may interact with other medications, so it is important to tell your healthcare provider about all the medications you are taking.
  • Lamictal can cause dizziness and drowsiness, so it is important to be careful when driving or operating machinery.
  • Lamictal may cause an increase in suicidal thoughts and behaviors, especially in young adults, so it is important to be aware of any changes in mood or behavior.
  • When discontinuing lamotrigine, it is recommended to do so in a stepwise fashion over two weeks, if possible, as there is a risk of withdrawal seizures when the drug is stopped abruptly.
  • Breastfeeding while taking this medication is not recommended due to the potential risk of Lamictal passing into the breast milk. It is advisable to discuss any potential risks with a healthcare provider before making any decisions about taking Lamictal while breastfeeding.

What Should I Avoid While Taking Lamotrigine?

Avoid drinking alcohol or using illegal drugs while you are taking lamotrigine. They may decrease the benefits (e.g., worsen your condition) and increase adverse effects (e.g., sedation) of the medication.

How Long Does It Take for Lamotrigine to Work?

It is especially important to tell your doctor how you feel things are going during the first few weeks after you start taking lamotrigine. It may take several weeks to see big enough changes in your symptoms to decide if lamotrigine is the right medication for you.

Are There Specific Concerns About Lamotrigine and Pregnancy?

If you are planning to become pregnant, notify your healthcare provider so that he/she can best manage your medications. People living with bipolar disorder who wish to become pregnant face important decisions. It is important to discuss the risks and benefits of treatment with your doctor and caregivers.

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Additional Information Book
Generic name:

Lamotrigine
Formulation:

Tablet
Strength(s):

25mg, 50mg, 100mg, 150mg, 200mg
Quantities Available:

56, 60, 90, 100, 112, 168

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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Lamictal (Lamotrigine). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Lamictal (Lamotrigine).