Table of contents:
Indications
Lamictal XR is a prescription medication used to help prevent the extreme mood swings of bipolar disorder in adults. Lamictal XR works by stabilizing electrical activity in the brain.
Lamictal XR is an anti-epileptic medication used for adjunctive therapy for primary generalized tonic-clonic seizures and partial-onset seizures with or without secondary generalization in patients aged 13 years and older. It can be used alone or together with other medications to treat seizures.
Use and Dosage
Lamictal XR (lamotrigine XR) is available in tablet form and should be taken with or without food, usually once daily or as instructed by a healthcare provider. Swallow the tablets whole, and not crush or chew them, as doing so can release all the drug at once, increasing the risk of side effects.
The recommended dosage of Lamotrigine XR (extended release) depends on the individual's condition and medications they are taking. However, here are a few general dosing guidelines:
- For patients not taking enzyme-inducing antiepileptic drugs (AEDs), the recommended initial dose is 25mg once daily for 2 weeks, then 50mg once daily for 2 weeks, then a maintenance dose of 200mg once daily.
- For patients taking enzyme-inducing AEDs but not valproic acid, the recommended initial dose is 50mg once daily for 2 weeks, then 100mg/day divided q12hr for 2 weeks, then a maintenance dose of 300mg/day given once daily.
- For patients taking valproic acid, the recommended initial dose is 25mg once every other day for 2 weeks, then 25mg once daily for 2 weeks, then a maintenance dose of 200-400mg/day depending on the individual's specific situation.
Dosage is based on medical condition, response to treatment, and use of certain interacting drugs. If switching from the immediate release form of this medication, the doctor will usually start with a similar dose to what was taken with the immediate release form.
Follow the doctor's dosing instructions exactly, as the dose must be increased slowly. It may take several weeks or months to reach the best dose and get the full benefits of the medication. To help remember taking it, use it at the same time each day.
Do not stop taking Lamictal XR tablets without consulting a healthcare provider. Some conditions may worsen when the drug is suddenly stopped. The dose may need to be gradually decreased. If someone has stopped taking this medication, do not restart lamotrigine without consulting a healthcare provider.
Side Effects
Common Side Effects of Lamictal XR (Lamotrigine Xr):
- Anxiety
- Back pain
- Constipation
- Cough
- Diarrhea
- Dizziness
- Double vision
- Dry mouth
- Flu-like symptoms
- Indigestion
- Nausea
- Tremor
- Trouble sleeping
- Trouble with balance and coordination
- Vomiting
- Worsening seizure
Serious Side Effects of Lamictal XR (Lamotrigine XR):
- Allergic reactions: skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Blistering
- Change in vision
- Dark yellow or brown urine
- Including inside the mouth
- Light-colored stool
- Loss of appetite
- Peeling or loosening of the skin
- Redness
- Right upper belly pain
- Swollen lymph nodes
- Thoughts of suicide or self-harm, worsening mood, or feelings of depression
- Trouble breathing
- Unusual bruising or bleeding
- Unusual weakness or fatigue
- Yellowing skin or eyes
Forms and Strength
Lamictal XR (Lamotrigine Xr) is available in the following forms and strength:
Lamotrigine Xr: Extended-Release Tablet
- 50 mg
- 100 mg
- 200 mg
Cautions
- The potential for medication errors is due to the similarity in product names with other medications.
- The risk of developing a serious rash, especially if the starting dose is too high or the dose is increased too quickly.
- The need to use caution when prescribing the medication to patients with significant renal impairment.
- Lamictal XR has not been established as safe and effective for use in children under the age of 13.
- The possibility of side effects, which may include dizziness, headache, nausea, and skin rash.
- The need to closely monitor patients for signs of suicidal thoughts or behavior, as the medication has been associated with an increased risk of suicidal ideation.
- The increased risk of heart rhythm problems in patients with seizure disorders.
- The need to avoid abrupt discontinuation of the Lamictal XR due to the potential for withdrawal seizures.
- The need for appropriate dose adjustments when Lamictal XR is used in combination with other medications that affect liver enzymes.
- The fact that Lamictal XR may decrease the effectiveness of hormonal contraceptives and the need to use additional forms of contraception while taking the medication.
- The need to avoid driving or operating machinery until the effects of the medication are known, as it may cause dizziness or drowsiness.
- The potential for the medication to interact with other medications or supplements, and the importance of discussing all current medications and supplements with a healthcare professional before starting treatment with Lamictal XR.
Frequently Asked Questions (FAQ)
Is Lamictal XR safe to take during pregnancy?
The safety of Lamictal XR during pregnancy has not been established. Women who are pregnant or planning to become pregnant should discuss the risks and benefits of taking Lamictal XR with a healthcare professional.
Is it safe to stop taking Lamictal XR abruptly?
No, it is not safe to stop taking Lamictal XR abruptly. Doing so may increase the risk of withdrawal seizures.
Can Lamictal XR cause weight gain?
Weight gain is not a common side effect of Lamictal XR. Patients who experience unusual weight gain or other side effects should consult their healthcare professional.
What should I do if I miss a dose of Lamictal XR?
If you miss a dose of Lamictal XR, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Resources
It's important to purchase Lamictal XR from verified Canadian pharmacy.
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