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Zoladex (generic name: goserelin) is a medication used to treat certain types of cancer, such as prostate and breast cancer. It is used to thin the lining of the uterus and may be used as a palliative treatment to help ease symptoms such as bone pain and trouble urinating. Zoladex is a synthetic decapeptide analogue of GnRH and works by inhibiting pituitary gonadotropin secretion, resulting in decreased levels of estrogen and testosterone.
Zoladex is an injectable medication used to treat a number of medical conditions for over 25 years. It is most used to treat cancer and endocrine disorders, but it can also be used to relieve symptoms of premenstrual syndrome (PMS) and other menstrual-related issues.
Uses and Dosage
Zoladex is available in a pre-filled disposable syringe device, which is fitted with a small pellet containing goserelin acetate, the active ingredient.
Here are some general steps to follow:
- Remove the plastic safety tab and needle cover from the disposable syringe.
- Pinch the skin and use aseptic technique to prepare the injection site.
- Insert the syringe into the prepared injection site at a 30–45-degree angle and slowly depress the plunger to administer the medication.
- After injecting the medication, remove the syringe from the injection site and dispose of it properly.
- Monitor the injection site and contact a healthcare professional if there are any signs of infection or other adverse reactions.
The recommended dosage of Zoladex can depend on numerous factors such as the type of cancer being treated and the individual's medical history. Here are some general recommended dosages based on the available information:
- For the palliative treatment of prostate cancer: Zoladex 3.6mg implant injected subcutaneously (below the navel line in the abdomen) every four weeks.
- For the palliative treatment of breast cancer: Zoladex 3.6mg implant injected subcutaneously every four weeks.
- For thinning the lining of the uterus: Zoladex 3.6mg implant injected subcutaneously every four weeks, for up to six months.
Make sure to follow the specific instructions and guidance provided by a healthcare professional for proper use and disposal of the disposable syringe.
Common Side Effects of Zoladex (Goserelin):
- Bloating and fluid retention (buildup)
- Fatigue (lack of energy)
- Hot flashes
- Injection site reactions
- Insomnia (trouble falling or staying asleep)
- Joint pain
- Loss of appetite
- Lung conditions, such as chronic obstructive pulmonary disease (copd)
- Mood changes
- Muscle weakness
Serious Side Effects of Zoladex (Goserelin):
- Allergic reaction
- Belly pain
- Burning pain that spreads to your arms, buttocks, or legs
- Chest pain
- Cramping, numbness, or weakness in your arms or legs
- Extreme thirst
- Feeling hopeless or pessimistic
- Feeling irritable (easily frustrated or upset)
- Frequent urination
- Increased thirst
- Irregular heartbeat
- Loss of energy or feeling “slowed down”
- Loss of feeling in your feet
- Loss of interest in hobbies or activities
- Pain and stiffness in your back or neck
- Shortness of breath
- Trouble concentrating
- Trouble remembering things
- Tumor flare (growth of a tumor for a very short time)
Form and strength
Zoladex (Goserelin) is available in the following forms and strength:
Zoladex: Disposable Syringe
- 3.6 mg
- Caution should be taken while injecting Goserelin into the anterior abdominal wall due to the risk of injury to underlying structures.
- Discuss any specific medical conditions, allergies, or other concerns with a healthcare professional before starting treatment with Goserelin.
- Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using goserelin safely.
- Zoladex can temporarily halt ovulation and menstruation and may impact fertility in women. It can also reduce sperm count and affect fertility in men. However, fertility typically returns after discontinuing Goserelin
- Goserelin may interact with other medications, including hormonal contraceptives and anticoagulants. Disclose all medications and supplements being taken to a healthcare professional before starting treatment with Zoladex.
- Goserelin should not be used during pregnancy or breastfeeding, unless it is being used for the treatment of advanced breast cancer. Before starting treatment with Zoladex, discuss any potential risks and benefits with a healthcare professional.
Frequently Asked Questions (FAQ)
Is Zoladex safe for everyone?
Zoladex may not be safe for everyone, and discuss any specific medical conditions, allergies, or other concerns with a healthcare professional before starting treatment with Goserelin.
What should I do if I miss a Zoladex injection?
If you miss an appointment for a Zoladex injection, contact your healthcare professional to reschedule as soon as possible. It is important not to double up on doses or alter the administration schedule without first consulting with a healthcare professional.
How long does it take for Zoladex to start working?
The onset of action of Zoladex varies depending on the indication it is being used for. In the case of prostate cancer, it may take a few weeks to months for the medication to have its full effect.
Can Zoladex be used during pregnancy or breastfeeding?
Zoladex should not be used during pregnancy or breastfeeding. Discuss any potential risks and benefits with a healthcare professional before starting or continuing treatment with Zoladex.
It's important to purchase Zoladex from verified Canadian pharmacy.