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Zaroxolyn (Metolazone) Shopper Approved

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Zaroxolyn

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Prescription Prescription Required FormationFormulation: Tablet

Metolazone

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Zaroxolyn contains the active ingredient metolazone. It is a prescription medication used to reduce extra fluid in the body and to help lower high blood pressure.

Edema

Zaroxolyn is used to treat edema, which means swelling caused by too much fluid in the body.

It may be prescribed when edema is related to conditions such as:

  • Congestive heart failure
  • Kidney disease
  • Nephrotic syndrome

By helping the body remove extra salt and water, Zaroxolyn can reduce swelling in areas such as the legs, ankles, and feet.

High Blood Pressure

Zaroxolyn may also be used to treat high blood pressure.

It may be taken alone or together with other blood pressure medications.

Lowering blood pressure can help reduce the long-term risk of problems such as stroke, heart attack, and kidney damage.

How Zaroxolyn Works

Zaroxolyn belongs to a group of medications called thiazide-like diuretics, sometimes called water pills.

It helps the kidneys remove more sodium and water through the urine.

This reduces the amount of extra fluid in the body and can also help lower blood pressure.

Important Note

Zaroxolyn can also affect electrolytes such as potassium and sodium.

Your healthcare provider may order blood tests during treatment to monitor your electrolyte levels, kidney function, and response to the medication.

Zaroxolyn comes as a tablet that is taken by mouth, usually once daily.

Take it at about the same time each day and exactly as prescribed by your healthcare provider.

Recommended Dose for High Blood Pressure

For mild to moderate high blood pressure, the usual dose is:

2.5 to 5 mg once daily.

Your healthcare provider will choose the lowest dose that controls your blood pressure effectively.

Recommended Dose for Edema

For swelling caused by heart failure or kidney disease, the usual dose is:

5 to 20 mg once daily.

The exact dose depends on how much fluid you are retaining and how well you respond to treatment.

Your Dose May Be Adjusted

The dose of Zaroxolyn is individualized.

Your healthcare provider may adjust it based on:

  • Blood pressure
  • Swelling
  • Kidney function
  • Electrolyte levels
  • How much urine you produce
  • Your overall response to treatment

The goal is to use the lowest effective dose that controls your symptoms.

When Does Zaroxolyn Start Working?

When Zaroxolyn is used for edema, increased urination may begin within about 1 hour after a dose and can continue for 24 hours or longer.

For high blood pressure, it may take several days or longer to see the full effect.

Take Zaroxolyn Regularly

Take Zaroxolyn every day as prescribed, even if you feel well.

High blood pressure often does not cause noticeable symptoms, so the medication may still be working even when you do not feel any different.

Do Not Change Your Dose on Your Own

Do not take more or less Zaroxolyn than prescribed.

Taking too much can cause excessive fluid loss or electrolyte problems, while taking too little may not adequately control your blood pressure or swelling.

Do not stop taking Zaroxolyn without speaking with your healthcare provider.

Common Side Effects of Zaroxolyn (Metolazone):

  • Constipation
  • Depressed mood
  • Diarrhea
  • Dizziness
  • Drowsiness
  • Loss of appetite
  • Muscle or joint pain
  • Nausea
  • Numbness or tingly feeling
  • Spinning sensation
  • Stomach pain
  • Tiredness

Serious Side Effects of Zaroxolyn (Metolazone):

  • Burning in your eyes and
  • Chest pain
  • Clay-colored stools
  • Confusion
  • Constipation
  • Dark urine
  • Difficulty breathing
  • Drowsiness
  • Dry mouth
  • Easy bruising
  • Feeling unsteady
  • Fever
  • Fluttering in your chest
  • Headache
  • Hives
  • Increased thirst or urination
  • Irregular heartbeats
  • Itching
  • Lack of energy
  • Leg cramps
  • Lightheadedness
  • Limp feeling
  • Little or no urination
  • Loss of appetite
  • Loss of coordination
  • Muscle pain
  • Muscle weakness
  • Nausea
  • Numbness
  • Pounding heartbeats
  • Restlessness
  • Severe weakness
  • Skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling
  • Slurred speech
  • Sore throat
  • Swelling of your face, lips, tongue, or throat
  • Tingling
  • Tiredness
  • Unusual bleeding
  • Upper stomach pain
  • Vomiting
  • Weakness
  • Yellowing of the skin or eyes

Zaroxolyn (Metolazone) is available in the following forms and strength:

Zaroxolyn: Tablet 

  • 2.5 mg

Metolazone: Tablet

  • 5 mg

Allergic Reactions

Do not take Zaroxolyn if you are allergic to metolazone or any ingredient in the medication.

Seek medical attention if you develop:

  • Hives
  • Severe rash
  • Swelling of the face, lips, tongue, or throat
  • Difficulty breathing or swallowing

Electrolyte Imbalances

Zaroxolyn can cause changes in electrolytes, especially potassium and sodium.

Low potassium may cause:

  • Muscle weakness
  • Muscle cramps
  • Unusual tiredness
  • Irregular heartbeat

Low sodium may cause:

  • Headache
  • Confusion
  • Weakness
  • Nausea
  • Seizures in severe cases

Your healthcare provider may order blood tests to monitor your electrolyte levels during treatment.

Dehydration and Low Blood Pressure

Because Zaroxolyn removes extra fluid from the body, it can sometimes cause dehydration or low blood pressure.

You may feel:

  • Dizzy
  • Lightheaded
  • Weak
  • Faint

Stand up slowly from a sitting or lying position.

Contact your healthcare provider if you develop severe dizziness, fainting, very dry mouth, or a large decrease in urination.

Kidney Problems

Tell your healthcare provider if you have kidney disease.

Zaroxolyn can affect kidney function, especially if you become dehydrated or take other medicines that affect the kidneys.

Your healthcare provider may monitor your kidney function during treatment.

Liver Problems

Zaroxolyn should be used carefully in people with liver disease.

Changes in fluid and electrolyte levels may be more serious in people with severe liver problems.

Tell your healthcare provider if you have cirrhosis or another significant liver condition.

Diabetes and Blood Sugar

Zaroxolyn may raise blood sugar levels.

If you have diabetes, you may need closer monitoring of your blood glucose while taking this medication.

Your diabetes treatment may need to be adjusted if your blood sugar changes significantly.

Gout and Uric Acid

Zaroxolyn may raise uric acid levels in the blood.

This can trigger or worsen gout in some people.

Tell your healthcare provider if you have gout or a history of high uric acid levels.

Drug Interactions

Zaroxolyn can interact with several medications.

Important examples include:

  • Lithium
  • Digoxin
  • NSAIDs such as ibuprofen or naproxen
  • Other diuretics
  • Blood pressure medications

Tell your healthcare provider about all prescription medications, over-the-counter products, vitamins, supplements, and herbal products you use.

Lithium

Taking Zaroxolyn with lithium can increase lithium levels and raise the risk of toxicity.

If both medications are needed, your healthcare provider may monitor lithium levels closely.

Digoxin

Low potassium caused by Zaroxolyn can increase the risk of side effects from digoxin, including abnormal heart rhythms.

Your healthcare provider may monitor your potassium level and heart function if you take both medicines.

Pregnancy

Tell your healthcare provider if you are pregnant or planning to become pregnant.

Your healthcare provider will decide whether Zaroxolyn is appropriate based on your condition and the expected benefits and risks.

Breastfeeding

Metolazone can pass into breast milk.

Tell your healthcare provider if you are breastfeeding so they can determine whether Zaroxolyn is appropriate for you.

Older Adults

Older adults may be more sensitive to dehydration, low blood pressure, electrolyte changes, and kidney problems.

Closer monitoring or a lower dose may sometimes be needed.

When to Contact Your Healthcare Provider

Contact your healthcare provider promptly if you develop muscle cramps, severe weakness, confusion, repeated vomiting, fainting, an irregular heartbeat, or a significant decrease in urination.

These symptoms may be signs of dehydration, an electrolyte imbalance, or another serious reaction.

What type of diuretic is Zaroxolyn?

Zaroxolyn is a thiazide-like diuretic, also called a water pill. It belongs to a chemical group called quinazolines and works in a similar way to thiazide diuretics by helping the kidneys remove extra sodium and water from the body.

How long does it take for Zaroxolyn to work?

Zaroxolyn can begin increasing urination within about 1 hour after a dose. Its effect on fluid retention may continue for 24 hours or longer. You may notice swelling improve over the next several days, while the full blood pressure-lowering effect can take longer.

How often is metolazone taken?

Metolazone is usually taken once daily. Try to take it at about the same time each day and follow your healthcare provider’s instructions carefully. Do not take extra doses or take it more often than prescribed.

Is metolazone used for weight loss?

No. Metolazone is not a weight-loss medication. It removes excess fluid from the body, so your weight may decrease if you have swelling caused by heart failure, kidney disease, or another condition that causes fluid retention. This is a loss of excess water, not body fat. Do not use Zaroxolyn for weight loss unless it has been prescribed for a medical condition.

REVIEWS

Additional Information Book
Generic name:

Metolazone

Formulation:

Tablet

Strength(s):

2.5mg, 5mg

Quantities Available:

90, 100

Why customers love Online Pharmacies Canada

Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.

Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies.

How to Order

How much Zaroxolyn can I order at once from a Canadian pharmacy?

When ordering Zaroxolyn (metolazone) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is common for prescription medications to ensure adequate management of chronic conditions without frequent refills.

Here’s what you need to know:

Dosage and Quantity: Zaroxolyn is commonly prescribed in dosages of 2.5 mg, taken once daily. For a 90-day supply, this means you would order 90 tablets (90 days x 1 tablet per day).

Do you sell metolazone?

Yes, we sell metolazone on our website. You can enjoy low prices when you order through us. To purchase metolazone, you will need a valid prescription from your healthcare provider. We require this prescription to dispense the medication safely and appropriately. You have the option to submit your prescription by mailing it to us, faxing it, or uploading it through your online account.

Do you offer shipping of Zaroxolyn (metolazone) to the United States?

Yes, we ship Zaroxolyn (metolazone) to both the United States and Puerto Rico.

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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Zaroxolyn (Metolazone). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Zaroxolyn (Metolazone).