Indications
Sintrom is a prescription medication used to prevent and treat blood clots, including deep vein thrombosis (DVT) and pulmonary embolism, and to prevent strokes in people with atrial fibrillation. Its main active ingredient is Nicoumalone, which is a derivative of the coagulation inhibitor coumarin. It is a medication that belongs to the group of anticoagulants, also known as "blood thinners".
Sintrom works by reducing the concentration of prothrombin in the blood, which is a protein involved in blood clotting. This can help prevent the formation of clots within blood vessels and reduce the risk of thromboembolic events (e.g., strokes, heart attacks, pulmonary embolisms) in people who are at risk.
Sintrom is available in tablet form, and the dosage must be adjusted carefully to balance its anticoagulant effects with the risk of bleeding. As with all medications, follow the instructions of your healthcare provider and report any side effects or other concerns.
Use and Dosage
Sintrom comes in the form of tablets to be taken by mouth. Take Sintrom exactly as prescribed by a doctor. The starting dose is usually one 4mg tablet or three 1mg tablets per day. Your doctor will advise you on the exact dosage of Sintrom based on your specific needs and will monitor your response to the medication through regular blood tests. The dose may need to be adjusted over time depending on individual response.
Follow any specific instructions given by your doctor, including instructions on interactions with other medications and dietary restrictions. Do not stop or change the dosage of Sintrom without consulting with your doctor, as doing so may increase the risk of blood clots or bleeding complications.
If you miss a dose of Sintrom, take it as soon as possible. If it is close to the time for your next dose, skip the missed dose and take your next dose at the regular time. Do not take a double dose to make up for a missed dose. In case of any questions or concerns about using Sintrom, consult with your healthcare provider.
Side Effects
Common Side Effects of Sintrom (Nicoumalone):
- Diarrhea
- Fever
- Hives
- Itchy skin
- Loss of appetite
- Loss of hair
- Nausea
- Vomiting
Serious Side Effects of Sintrom (Nicoumalone):
- Bleeding from cuts that take a long time to stop
- Bleeding gums
- Headaches, dizziness, or weakness
- Heavier than normal menstrual bleeding
- Nosebleeds
- Numbness or tingling of the face, hands, or feet
- Pain, swelling, or discomfort
- Paralysis
- Pink or brown urine
- Sudden shortness of breath
- Unexplained bruising
- Unusual pain or swelling
Forms and Strength
Sintrom (Nicoumalone) is available in the following forms and strength:
Sintrom: Tablet
- 1mg
- 4mg
Nicoumalone: Tablet
- 1mg
- 2mg
Cautions
- Increased risk of bleeding: As an anticoagulant, Sintrom can increase the risk of bleeding. Therefore, caution should be exercised in people with a history of bleeding disorders, peptic ulcers, or recent surgery, as well as those on other medications that can increase bleeding risk (e.g., aspirin, nonsteroidal anti-inflammatory drugs).
- Dosage adjustment: The dosage of Sintrom needs to be carefully adjusted based on the individual's coagulation status, age, weight, and any other medical conditions or medications they may be taking.
- Monitoring: Regular monitoring of coagulation status is necessary to ensure that Sintrom is effective and that there are no unexpected changes in coagulation.
- Contraindications: Sintrom should not be used in people with active bleeding, bleeding disorders, or a history of hypersensitivity to coumarin derivatives.
- Interactions with other medications: Sintrom can interact with a variety of medications including antibiotics, antifungal agents, anti-inflammatory drugs, and many others. Inform your healthcare provider of all medications you are taking before starting Sintrom.
- Diet: Sintrom interacts with vitamin K which is found in green leafy vegetables; maintain a consistent intake of vitamin K-containing foods. Changes in diet can affect Sintrom's effectiveness and dosage.
- Pregnancy and breastfeeding: Sintrom is contraindicated during pregnancy, as it can cross the placenta and cause bleeding in the fetus. It is also not recommended during breastfeeding, as it can pass into breast milk and potentially cause bleeding in the nursing infant.
- Regular medical checkups: Regular medical checkups are necessary to monitor the effectiveness of Sintrom and ensure there are no complications or unexpected changes in the individual's coagulation.
Frequently Asked Questions (FAQ)
What should I do if I miss a dose of Sintrom?
If you miss a dose of Sintrom, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule.
Can I take Sintrom with other medications?
Sintrom can interact with many medications, inform your healthcare provider of all medications you are taking before starting Sintrom.
How long do I need to take Sintrom?
The duration of treatment with Sintrom depends on the individual's condition and response to treatment. Follow the instructions of your healthcare provider and continue taking the medication as prescribed.
Can I drink alcohol while taking Sintrom?
Consuming alcohol while taking Sintrom can increase the risk of bleeding. Limit or avoid alcohol consumption while taking the medication.
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