Vivelle DOT (Estradiol Hemihydrate)

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Vivelle DOT Brand
Dosage Quantity & Price
Estradiol Hemihydrate (Generic alternate to Vivelle DOT) Generic

We don't sell this generic-version medication.

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Table of contents:

Vivelle-Dot is a prescription patch used to reduce symptoms of menopause such as hot flashes, vaginal dryness, burning, and irritation. It is indicated to release estradiol continuously upon application to the skin and is prescribed as hormone replacement therapy to menopausal women with a uterus. Vivelle-Dot is a transdermal patch that contains estradiol, a female hormone (estrogen). When applied to the skin, the patch slowly releases estradiol into the bloodstream over three to four days.

The estradiol in Vivelle-Dot works by binding to estrogen receptors in different tissues throughout the body, including the brain, bones, and reproductive organs. By binding to these receptors, estradiol can help relieve symptoms of menopause and may also have other benefits such as improving bone density and reducing the risk of osteoporosis.

Uses and Dosage

Vivelle-Dot Patch is applied to the lower stomach or upper buttock area twice a week on the same days each week. The dosage and frequency of application depend on the severity of symptoms and other patient factors and should be determined by a healthcare professional.

Before applying the patch, make sure that the skin is clean, dry, and free from any lotion or cream. Remove the patch from its packaging and peel off the protective liner to expose the adhesive side. Apply the patch to the designated area and press firmly in place with the palm of your hand for 10 seconds. Do not rub the patch.

Remove the old patch before applying a new one and change the application site to avoid irritation. One patch should be worn continuously for three to four days (72-96 hours) before replacing it with a new one. If a patch falls off, you can reapply it or replace it with a fresh one. If you miss a dose, apply a new patch as soon as possible and continue with your regular dosing schedule. Do not apply more than one patch at a time.

Side effect

Common Side Effects of Vivelle DOT (Estradiol Hemihydrate):

  • Acne
  • Bloating
  • Breast tenderness
  • Constipation
  • Headache
  • Nausea
  • Redness or irritation on the application site
  • Stomach upset
  • Vomiting
  • Weight changes

Serious Side Effects of Vivelle DOT (Estradiol Hemihydrate):

  • Breast lumps
  • Dark urine
  • Fainting
  • Increased thirst or urination
  • Increased vaginal irritation
  • Mental or mood changes, including memory loss or depression
  • Persistent vomiting
  • Severe abdominal pain
  • Swelling of the extremities
  • Symptoms of blood clots (chest pain, severe headache, unusual sweating, confusion, weakness on one side of the body, trouble speaking, coughing out blood)
  • Trouble breathing
  • Unusual vaginal bleeding

Form and strength

Vivelle DOT (Estradiol Hemihydrate) is available in the following forms and strength:

Vivelle DOT: Transdermal Patches

  • 25 mcg
  • 37.5 mcg
  • 50 mcg
  • 75 mcg
  • 100 mcg


  • Vivelle-Dot should not be used in women who are pregnant or breastfeeding.
  • Vivelle-Dot should not be used in women who have or have had a history of breast cancer, uterine cancer, or any other hormone-sensitive cancer.
  • Vivelle-Dot should not be used in women who have a history of blood clots, stroke, or heart attack.
  • Women using Vivelle-Dot should have regular check-ups with their healthcare provider to monitor their hormone levels and any potential side effects.
  • Common side effects of Vivelle-Dot include nausea, vomiting, breast tenderness, cramps, bloating, change in vaginal discharge, and mood changes.
  • Women using Vivelle-Dot should be advised to report any unusual vaginal bleeding, as this may be a sign of a serious condition.
  • Women using Vivelle-Dot should be advised to avoid smoking, as this may increase their risk of side effects and complications.
  • Women with liver problems should be closely monitored while using Vivelle-Dot, as the medication may worsen their condition.
  • Women with a history of high blood pressure, diabetes, or high cholesterol should be monitored closely while using Vivelle-Dot.
  • Vivelle-Dot may increase the risk of developing gallbladder disease.
  • Women using Vivelle-Dot should be advised not to use other estrogen-containing products at the same time, as this may increase their risk of side effects.
  • The use of Vivelle-Dot may increase the risk of certain cancers, including breast cancer, ovarian cancer, and endometrial cancer.
  • Women using Vivelle-Dot should be advised to have regular breast examinations and mammograms.
  • Women using Vivelle-Dot should be advised to inform their healthcare provider if they notice any changes in their breasts, such as lumps, pain, or discharge.

Frequently Asked Questions (FAQ)

Does the estradiol patch contain progestin?

No. The estradiol patch only contains estradiol (a form of estrogen).

Is Vivelle-Dot used for fertility?

The Vivelle patch is a form of estrogen that can be used as a form of priming and helps maintain an early pregnancy.

Vivelle-Dot a natural estrogen?

The active ingredient in Vivelle-Dot, estradiol, is a form of the hormone estrogen. It replaces estrogen that is not naturally produced by the ovaries.

How long should I use Vivelle-Dot?

Give Vivelle-Dot continuously in a woman who does not have an intact uterus. In a woman with an intact uterus, give Vivelle-Dot on a cyclic schedule (for example, 3 weeks on Vivelle-Dot followed by 1 week off Vivelle-Dot).


It's important to purchase Vivelle DOT from verified Canadian pharmacy.

Additional information

Generic name:

Estradiol Hemihydrate


Transdermal Patches


25mcg, 37.5mcg, 50mcg, 75mcg, 100mcg

Quantities Available:

8, 16, 24


Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Vivelle DOT (Estradiol Hemihydrate). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Vivelle DOT (Estradiol Hemihydrate).