Indications
Lutrepulse is a medication used to induce ovulation in women with primary hypothalamic amenorrhea. It contains the active ingredient gonadorelin acetate. Gonadorelin belongs to the class of medications called ovulatory agents.
Gonadorelin is a gonadotropin-releasing hormone agonist (GnRH agonist), which stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. This, in turn, triggers ovulation in women.
Use and Dosage
Lutrepulse is a medication that comes in the form of a 0.8 mg/vial. The vial of Lutrepulse is designed to be administered by injection, either subcutaneously (under the skin) or intravenously using an infusion pump. The medication can cause harm if used inappropriately, so it should only be administered under the guidance of a healthcare professional who has prescribed it.
Use Lutrepulse exactly as prescribed by your doctor. Your doctor will monitor how you are responding to the medication and frequent appointments will be necessary. If the needle comes out or if there is blood in the tubing, contact your doctor.
Side Effects
Common Side Effects of Lutrepulse (Gonadorelin):
- Headache
- Irritation at the site of injection
- Nausea
Serious Side Effects of Lutrepulse (Gonadorelin):
- Abdominal or stomach discomfort
- Difficulty in breathing
- Flushing (continuing or lasting only a brief time)
- Hardening of skin at place of injection
- Headaches
- Hives
- Itching, pain, redness or swelling of skin at place of injection
- Lightheadedness
- Nausea
- Rapid heartbeat
- Skin rash (at place of injection or over entire body)
Forms and Strength
Lutrepulse (Gonadorelin) is available in the following forms and strength:
Lutrepulse: Vial
- 0.8 mg
Cautions
- Lutrepulse should only be administered under the supervision of a qualified healthcare provider who is experienced in the use of ovulatory agents.
- Lutrepulse should not be used by women who are pregnant or breastfeeding, as it may harm the fetus or nursing infant.
- Lutrepulse should be used with caution in patients with a history of seizure disorders, as it may cause seizures.
- Lutrepulse may cause side effects such as headaches, dizziness, nausea, vomiting, hot flashes, or allergic reactions. If any of these side effects occur, the patient should notify their healthcare provider immediately.
- Lutrepulse may interact with other medications, including hormonal contraceptives, and should not be used in combination with them without consulting a healthcare provider.
- Lutrepulse may cause ovarian hyperstimulation syndrome (OHSS), a potentially serious condition that can lead to fluid buildup in the abdomen and chest, blood clots, kidney failure, or other complications. Patients should be monitored closely for signs of OHSS during Lutrepulse treatment.
- Lutrepulse should be used with caution in patients with a history of cardiovascular disease, as it may cause changes in blood pressure or heart rate.
- Lutrepulse may cause mood changes or depression in patients and should be used with caution in those with a history of psychiatric illness.
- Lutrepulse may cause a decrease in bone density and should be used with caution in patients with a history of osteoporosis or other bone disorders.
- Lutrepulse may alter the results of certain laboratory tests, including pregnancy tests and tests for thyroid function, among others. Patients should inform their healthcare provider of all medications they are taking before undergoing any laboratory testing.
- Lutrepulse should not be used for extended periods of time, as it may lead to reduced fertility or other complications. Patients should discuss the risks and benefits of prolonged Lutrepulse use with their healthcare provider.
- Lutrepulse should only be used in women of reproductive age who are attempting to conceive, as it may interfere with normal hormonal balance in other populations.
Frequently Asked Questions (FAQ)
How long does it take for Lutrepulse to work?
The time frame for Lutrepulse to work may vary depending on the individual patient and their response to treatment. Patients should follow their healthcare provider's instructions regarding Lutrepulse treatment.
How should Lutrepulse be stored?
Lutrepulse should be stored at room temperature, away from heat and light. Patients should follow their healthcare provider's instructions regarding storage and disposal of Lutrepulse.
Can Lutrepulse be used without a prescription?
No, Lutrepulse should only be used under the supervision of a qualified healthcare provider who is experienced in the use of ovulatory agents.
What should I do if I overdose on Lutrepulse?
Patients who suspect that they have overdosed on Lutrepulse should seek medical attention immediately.
Resources
- https://clinicaltrials.gov/ct2/show/NCT01976728
- https://www.medbroadcast.com/drug/getdrug/lutrepulse
- https://www.webmd.com/drugs/2/drug-4056/lutrepulse-injection/details
- https://www.mayoclinic.org/drugs-supplements/gonadorelin-intravenous-route-injection-route/precautions/drg-20067426
- https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncim/C0706930
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