Divigel (Estradiol Gel)

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Divigel Brand
Dosage Quantity & Price
Estradiol Gel (Generic alternate to Divigel) Generic

We don't sell this generic-version medication.

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Table of contents:

Divigel is a medication used to treat moderate to severe vasomotor symptoms (hot flashes and night sweats) in women caused by menopause. Its active ingredient is estradiol, which is a female hormone (estrogen).

Divigel comes in the form of a gel that is absorbed through the skin and enters the bloodstream. Once absorbed in the bloodstream, estradiol works by binding to estrogen receptors in various tissues in the body. This can help reduce the frequency and intensity of hot flashes and other menopausal symptoms.

Uses and Dosage

Divigel is available in 1.0, 0.5, and 0.25 gram-filled single-dose foil packets. Divigel is applied topically to the skin, typically to a small area on the upper thigh, once a day. Do not apply the gel on broken or irritated skin and other areas like the breast, face, or vagina. Additionally, Divigel has a drug quantity management program to promote safe and effective use.

To use Estradiol Gel, follow these general steps:

  1. Clean the area where you will apply the gel with soap and water and dry it completely.
  2. Open the Estradiol Gel packet and remove the cap from the pump bottle.
  3. Prime the pump by pressing down on it several times until the gel appears at the top of the pump.
  4. Apply the gel to your skin (usually the upper thigh or arm) according to your doctor's directions.
  5. Rub the gel onto your skin gently until it is absorbed, and the area is dry.
  6. Close the pump bottle and wash your hands with soap and water.
  7. Do not cover the area where the gel was applied with clothing or bandages for at least one hour.

The recommended dosages of Divigel may vary depending on the individual patient's medical condition and other factors. Consult with a healthcare provider before starting or changing the dosage of Divigel to ensure safe and effective use.

 Side effect

Common Side Effects of Divigel (Estradiol Gel):

  • Acne or skin discoloration
  • Bloating
  • Dizziness
  • Headache
  • Loss of appetite
  • Nausea
  • Swollen breast
  • Vomiting
  • Weight changes

Serious Side Effects of Divigel (Estradiol Gel):

  • Breast lumps
  • Dark urine
  • Increased vaginal irritation
  • Mental or mood changes
  • Persistent nausea and vomiting
  • Severe abdominal pain
  • Signs of blood clots (chest pain, trouble breathing, coughing out blood, slurred speech, sudden dizziness, severe headache, vision changes, confusion)
  • Unusual vaginal bleeding

Form and Strength

Divigel (Estradiol Gel) is available in the following forms and strength:

Divigel: Gel Sachet

  • 0.25 mg
  • 0.5 mg
  • 1 mg


  • Estrogen-alone use increases the risk of uterus (womb) cancer. Any unusual vaginal bleeding should be reported to a healthcare provider right away while using Divigel. Postmenopausal vaginal bleeding may be a warning sign of uterus (womb) cancer.
  • Using estrogen alone may increase the risk of strokes or blood clots. Do not use estrogen-alone to prevent heart disease, heart attacks, and strokes.
  • Using estrogen-alone may increase the risk of dementia in women 65 years of age or older.
  • Avoiding its use if you have a known allergy to estradiol or any inactive ingredients the gel may contain. If you experience signs of hypersensitivity, such as skin rashes, itchiness, swelling of the face and neck, severe dizziness, and trouble breathing, immediately discontinue the medication and seek emergency medical help.
  • Avoid smoking, using tobacco, or any similar substances that may contain nicotine. This certain substance could increase the risk of high blood pressure, blood clots, heart attack, and stroke, especially among women 35 years of age and older.

Frequently Asked Questions (FAQ)

Do I need a prescription to use Divigel?

Yes, Divigel is a prescription medication and should only be used under the guidance of a healthcare provider.

How long should I use Divigel for?

The duration of Divigel usage should be determined by a healthcare provider and will depend on individual circumstances and medical history.

Can Divigel be used during pregnancy or breastfeeding?

No, Divigel should not be used during pregnancy or breastfeeding.

Can Divigel cause weight gain?

Weight gain is not a common side effect of Divigel, but it is possible. Women should speak with their healthcare provider about potential side effects.

Can Divigel increase the risk of blood clots?

There is a slightly increased risk of blood clots associated with estrogen therapy, including Divigel. Women with a history of blood clots or certain medical conditions should discuss potential risks with their healthcare provider.

Can Divigel be applied to areas other than the upper thigh or stomach?

No, Divigel should only be applied to the skin of the upper thigh or stomach, as directed by a healthcare provider.

How quickly does Divigel work?

Divigel may begin to relieve hot flashes as quickly as two weeks after starting treatment. However, the duration and timing of symptom relief may vary for each woman.


It's important to purchase Divigel from verified Canadian pharmacy.

Additional information

Generic name:

Estradiol Gel


Gel Sachet


0.5mg, 0.25mg, 1mg

Quantities Available:

30 sachets, 90 sachets