Estraderm Patch (Estradiol) Shopper Approved

Prescription Prescription Required FormationFormulation: Trandsdermal Patch

Estraderm Patch

(Brand Option)

Select the prescribed dosage

Prescription Prescription Required FormationFormulation: Trandsdermal Patch


(Generic Alternative)

Select the prescribed dosage

Select the quantity to see the price.


We don't charge dispensing fee


Shipped and delivered directly to your doorstep


The Estraderm patch is a transdermal patch used for estrogen replacement therapy in women who are experiencing menopausal symptoms. It can be used for many bodily functions in women, including regulating the menstrual cycle, maintaining bone density, and controlling cholesterol levels. During menopause, the levels of estrogen in the body decrease, which can cause a variety of symptoms such as hot flashes, vaginal dryness, and mood changes.

Estraderm patch contains the hormone estradiol, which is absorbed through the skin and into the bloodstream. It works by providing the body with a steady dose of estrogen, which can help to restore hormonal balance and provide relief from menopausal symptoms.

Use and Dosage

Estraderm is supplied in the form of a patch that is applied to the skin. The frequency of patch application depends on the type of patch used, and it is usually applied once or twice a week. Some women wear the patch continuously, while others follow a rotating schedule of 3 weeks on and 1 week off.

Ensure that the patch is applied on the same day(s) of the week every week, as indicated on the calendar in the medication carton. Do not apply more or fewer patches or use them more often than prescribed by a healthcare provider.

General directions to follow when using Estraderm Patch:

  1. Tear open the pouch with your fingers. Do not use scissors because they may damage the patch. Do not open the pouch until you are ready to apply the patch.
  2. Remove the patch from the pouch. There may be a silver foil sticker used to protect the patch from moisture inside the pouch. Do not remove this sticker from the pouch.
  3. Remove the protective liner from the patch and press the sticky side of the patch against your skin in the area you have chosen to wear your patch. Some patches have a liner that is made to peel off in two pieces. If your patch has that type of liner, you should peel off one part of the liner and press that side of the patch against your skin. Then fold back the patch, peel off the other part of the liner and press the second side of the patch against your skin. Always be careful not to touch the sticky side of the patch with your fingers.
  4. Press down on the patch with your fingers or palm for 10 seconds. Be sure that the patch is firmly attached to your skin, especially around its edges.
  5. Wear the patch all the time until it is time to remove it. When it is time to remove the patch, slowly peel it off your skin. Fold the patch in half so that the sticky sides are pressed together and dispose of it safely, so that is out of reach of children and pets.
  6. If a sticky substance remains on your skin after you remove the patch, you should wait 15 minutes and then remove the substance using an oil or lotion.

Use the medication exactly as prescribed by your doctor. If you forget to apply or change your patch, change it as soon as you remember. If it is close to the day when you normally change your patch, still apply it but change the patch again on your usual day and continue with your regular schedule. Do not wear 2 patches at once. If you are not sure what to do after forgetting to apply or change the patch, contact your doctor or pharmacist for advice.

Side Effects

Common Side Effects of Estraderm Patch (Estradiol):

  • Acne
  • Back pain
  • Bloating
  • Break-through bleeding
  • Breast swelling or tenderness
  • Changes in your menstrual periods, and
  • Cold symptoms include a stuffy nose, sneezing, sinus ache, and a scratchy throat
  • Constipation
  • Headache
  • Increased facial hair
  • Joint pain
  • Nausea/vomiting
  • Nipple discharge
  • Skin color changes
  • Skin redness/irritation at the application site
  • Thinning scalp hair
  • Upset stomach
  • Weight changes

Serious Side Effects of Estraderm Patch (Estradiol):

  • A bulge in the breast or behind the arm
  • A persistent ache on the breast skin
  • Arm or leg discomfort, redness, or edema
  • Bloody or clear discharge from the nipple
  • Change in vaginal discharge
  • Decrease in the amount of urine
  • Dimpling of the breast skin
  • Eyelids, face, fingers, lips, hands, feet, or lower legs swelling
  • Fast heartbeat
  • Fever
  • Hives, itching, or rash
  • Hoarseness
  • Inverted nipple
  • Irritation
  • Joint pain, stiffness, or swelling
  • Noisy, rattling breathing
  • Pelvic discomfort or a sensation of pressure
  • Persistent crust or scaling of the nipple
  • Redness of the skin
  • Redness or swelling of the breast
  • Tightness in the chest
  • Troubled breathing at rest
  • Troubled breathing or swallowing
  • Vaginal bleeding
  • Vaginal yeast infection

Forms and Strength

Estraderm Patch (Estradiol) is available in the following forms and strength:

Estraderm Patch: Transdermal Patch

  • 25 mcg
  • 50 mcg

Estradiol: Patch

  • 50 mcg
  • 75 mcg
  • 100 mcg


  • Estraderm should be used with caution in individuals with a history of blood clots, stroke, heart attack, breast cancer, liver disease, or abnormal genital bleeding.
  • Estradiol may increase the risk of endometrial cancer, especially when used without a progestin in women who have not had a hysterectomy.
  • Estradiol may increase the risk of breast cancer, ovarian cancer, stroke, and blood clots.
  • Estraderm may interact with certain medications, including certain antifungal drugs, antibiotics, and antiseizure medications.
  • Estraderm should not be used during pregnancy or breastfeeding.
  • Estradiol may cause serious side effects, including blood clots, stroke, heart attack, breast cancer, and dementia in postmenopausal women.
  • Estradiol should be used with caution in individuals with high blood pressure, diabetes, asthma, epilepsy, migraines, lupus, or a history of depression.
  • Estraderm may cause skin irritation, itching, redness, or rash at the application site.
  • Estraderm should be used with caution in individuals with a history of gallbladder disease or if they tend to develop gallstones.
  • Estraderm may affect blood sugar levels and require adjustments in diabetic medication.

Frequently Asked Questions (FAQ)

Can the Estraderm patch be used for birth control?

No, the Estraderm patch is not a form of birth control and should not be used for this purpose.

Can I swim or bathe with the Estraderm patch on?

Yes, you can swim, bathe, shower, or exercise while wearing the Estraderm patch. However, avoid applying lotion or cream on the area where the patch is applied.

How long does it take for the Estraderm patch to start working?

The Estraderm patch can provide relief from symptoms of menopause within just a few weeks of starting treatment.

Can the Estraderm patch be cut or trimmed?

No, the Estraderm patch should not be cut or trimmed, as this can affect the amount of medication released and may lead to inconsistent doses.

What should I do if I experience side effects from the Estraderm patch?

If you experience side effects such as skin irritation, headaches, or nausea, you should talk to your doctor. They may recommend adjusting the dosage or switching to a different form of HRT.


Additional information

Generic name:

Estradiol, Estradiol Hemihydrate


Patch, Trandsdermal Patch


25mcg, 50mcg, 75mcg, 100mcg

Quantities Available:

8, 16, 24


Additional Information Book

If you have any Questions

Call Us

call us toll free


OR Email us at

[email protected]

Why customers love Online Pharmacies Canada

Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.

Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies. widget logo

Ordering Estraderm Patch just became easier

Discover Our Users' Stories!

Watch how Online Pharmacies Canada is helping customers save money on their medications.

Learn how Online Pharmacies Canada is helping customers save money on their medications.

Learn more about who we are

Generic vs Brand Name Drugs: Is There a Difference?

Generic vs Brand Name Drugs: Is There a Difference?

Many people want to know the difference between generic and brand-name drugs, especially when it comes to their health and their wallets. Knowing what sets these medications apart can help…

CIPA Certified Pharmacies Recognized as Safe in the US

Why does Canadian pharmacy require a prescription?

A medical prescription (often abbreviated as Rx) is a formal written order issued by a licensed healthcare professional, such as a physician, nurse practitioner, or dentist. This order authorizes a…

Affordable medications? You found what you�ve been looking for

List of general drug categories: A to Z

A drug category is a way of organizing medications into groups based on shared characteristics. These characteristics can include their chemical structure, how they work in the body, what they’re…

Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Estraderm Patch (Estradiol). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Estraderm Patch (Estradiol).