Prescription Required
Formulation: Cream
(Brand Option)
Select the prescribed dosage
Select the quantity to see the price.
Prescription Required
Formulation: Cream
Select the quantity to see the price.
* This price includes a dispensing fee, medical review fee, and packing fee.
Shipped and delivered directly to your doorstep
Premarin Vaginal Cream contains conjugated estrogens. It is a prescription estrogen treatment used to relieve vaginal and vulvar symptoms caused by lower estrogen levels after menopause.
Estrogen helps keep the tissues of the vagina and vulva healthy, moist, flexible, and well supplied with blood. After menopause, estrogen levels decrease. As a result, these tissues may become thinner, drier, less elastic, and more easily irritated.
These changes are sometimes called vaginal atrophy, vulvovaginal atrophy, or genitourinary syndrome of menopause.
Symptoms may include:
Premarin Vaginal Cream may be prescribed to treat atrophic vaginitis. This condition causes thinning, dryness, and inflammation of the vaginal tissues because of reduced estrogen levels.
The cream delivers estrogen directly to the affected area. Over time, it helps improve the thickness, moisture, and flexibility of the vaginal lining. This may reduce dryness, burning, itching, and irritation.
Premarin Vaginal Cream may also be used to treat moderate to severe dyspareunia, which means pain during sexual intercourse.
Pain may occur when the vaginal tissues become dry, thin, or less elastic. The cream helps restore moisture and improve tissue flexibility, which may make sexual activity more comfortable.
Some people may still benefit from using a vaginal moisturizer regularly or a water-based lubricant during sex. Ask your healthcare provider which products are suitable to use with Premarin Vaginal Cream.
Low estrogen can also affect the vulva and tissues around the urinary tract. Some patients may experience burning, irritation, frequent urination, urgency, or recurrent urinary discomfort.
Premarin Vaginal Cream may help some symptoms caused by low estrogen, but it does not treat every urinary problem. Symptoms such as painful urination, fever, blood in the urine, or strong-smelling urine may be signs of an infection and should be assessed by a healthcare provider.
Premarin Vaginal Cream belongs to a group of medications called estrogen replacement therapies.
The estrogen enters the vaginal tissues and helps restore some of the effects normally provided by the body’s natural estrogen. This can:
Improvement is usually gradual. Some symptoms may begin to improve within a few weeks, but the full effect may take longer.
Premarin Vaginal Cream is applied directly inside the vagina, so much of its effect occurs in the local tissues. However, some estrogen can still be absorbed into the bloodstream.
For this reason, the same types of serious warnings associated with systemic estrogen may still be relevant, especially with higher doses or longer treatment. Your healthcare provider will consider your medical history before prescribing it.
Tell your healthcare provider if you have or have had:
Your healthcare provider may recommend the lowest effective dose for the shortest appropriate treatment period.
When dryness, irritation, or pain during sex are the only menopausal symptoms, a local vaginal treatment may be preferred over an oral estrogen tablet.
Local treatment places estrogen closer to the affected tissues. However, the amount absorbed can vary between products and doses. Your healthcare provider will decide which form of treatment is most appropriate for you.
Use Premarin Vaginal Cream exactly as prescribed. Do not apply more cream, use it more often, or continue treatment longer than directed.
Attend regular follow-up appointments so your healthcare provider can review your symptoms, check for side effects, and decide whether you still need treatment.
Report any unusual vaginal bleeding or spotting promptly, especially after menopause. Also contact your healthcare provider if your symptoms become worse, do not improve, or return during treatment.
Premarin Vaginal Cream is applied inside the vagina using the calibrated applicator provided with the medication. Use the exact amount and schedule prescribed by your healthcare provider.
The recommended schedule depends on the condition being treated. For vaginal and vulvar changes caused by menopause, treatment may begin with 0.5 grams once daily for 21 days, followed by 7 days without treatment. This four-week cycle may then be repeated.
For moderate to severe pain during sex caused by menopausal vaginal changes, 0.5 grams may be used twice a week, such as every Monday and Thursday. A cyclic schedule may also be prescribed.
Your healthcare provider may adjust the amount from 0.5 to 2 grams depending on your symptoms and response to treatment. Do not increase the dose or apply the cream more often than prescribed.
Try to apply the cream at approximately the same time on each scheduled day. A bedtime dose may be more convenient because lying down afterward may reduce leakage, but follow the timing instructions provided by your healthcare provider.
Some cream may leak out after application. You may use an unscented panty liner if needed. Avoid using tampons to absorb the medication because they may remove some of the cream.
Contact your healthcare provider if you experience unusual vaginal bleeding, severe irritation, pelvic pain, or symptoms that do not improve.
Premarin Vaginal Cream (Conjugated Estrogen) is available in the following forms and strengths:
Before using Premarin Vaginal Cream, tell your healthcare provider about your full medical history, including any previous cancers, blood clots, heart or circulation problems, liver disease, unexplained vaginal bleeding, allergies, and possible pregnancy.
Do not use Premarin Vaginal Cream if you have unexplained vaginal bleeding. Bleeding or spotting after menopause should be examined before estrogen treatment begins because it may be caused by a problem affecting the uterus or cervix.
Premarin Vaginal Cream may also be unsuitable if you have or have previously had certain cancers that may be affected by estrogen, such as breast cancer or cancer of the uterine lining. Tell your healthcare provider about any history of cancer, even if your treatment was completed many years ago.
You should not use this medication if you currently have, or have previously had, a blood clot in a deep vein or the lungs. It may also be unsuitable if you have had a heart attack, stroke, or another condition involving blood clots in the arteries.
Do not use Premarin Vaginal Cream if you have liver disease or if your liver is not working normally. The liver helps process estrogen, and liver problems may cause the medication to build up in your body.
You should also avoid this medication if you have had a serious allergic reaction to conjugated estrogens or any ingredient in the cream.
Premarin Vaginal Cream is intended for use after menopause and should not be used during pregnancy.
Tell your healthcare provider if you think you may be pregnant. Although pregnancy is unlikely after menopause, it may still be possible during perimenopause or in people with irregular menstrual periods.
Contact your healthcare provider if you become pregnant while using the cream. Do not continue treatment unless they specifically advise you to do so.
Tell your healthcare provider if you have a bleeding or blood-clotting disorder. You should also mention any personal or family history of blood clots, stroke, heart attack, or unexplained miscarriages.
Other factors that may increase the risk of blood clots include smoking, obesity, limited mobility, recent surgery, long periods of bed rest, and certain inherited conditions.
Your healthcare provider may ask you to stop using estrogen temporarily before major surgery or during a prolonged period of immobility.
Premarin Vaginal Cream contains inactive ingredients in addition to conjugated estrogens. These ingredients help form, preserve, or stabilize the cream, but they may cause irritation or an allergic reaction in some people.
Before starting treatment, tell your healthcare provider or pharmacist about allergies to medications, foods, preservatives, dyes, or topical products.
Stop using the cream and seek immediate medical attention if you develop swelling of the face, lips, tongue, or throat, difficulty breathing, severe dizziness, hives, or a widespread rash.
Contact your healthcare provider if you experience severe vaginal burning, swelling, pain, or irritation after applying the cream.
If you still have your uterus, using estrogen without a progestogen can cause the uterine lining to become too thick. Over time, this may increase the risk of endometrial cancer.
Your healthcare provider may prescribe a progestogen along with Premarin Vaginal Cream to help protect the uterine lining. Whether you need a progestogen depends on the dose, treatment schedule, length of use, your medical history, and how much estrogen is absorbed into your bloodstream.
Do not start a progestogen on your own. Your healthcare provider will determine whether the benefits outweigh the possible risks.
Tell your healthcare provider promptly if you experience unusual vaginal bleeding or spotting while using Premarin Vaginal Cream.
This may include bleeding after menopause, bleeding between periods, bleeding that is heavier than expected, or bleeding that returns after it had stopped.
Unusual bleeding does not always mean that you have cancer. However, it should be investigated so that your healthcare provider can identify the cause and provide appropriate treatment.
Attend regular follow-up appointments while using vaginal estrogen cream, tablets, or rings. Your healthcare provider will review whether the medication is improving your symptoms and whether you still need treatment.
During these visits, your healthcare provider may review your vaginal bleeding, breast health, blood pressure, risk of blood clots, and any new medical conditions or medications.
Use Premarin Vaginal Cream at the lowest effective dose and for the shortest period appropriate for your treatment goals. Do not increase the dose, use it more often, or continue it longer than prescribed.
Seek immediate medical attention if you develop chest pain, sudden shortness of breath, coughing up blood, sudden vision or speech changes, weakness on one side of your body, or pain and swelling in one leg. These may be signs of a heart attack, stroke, or blood clot.
Premarin Vaginal Cream does not usually relieve symptoms immediately. Some people may begin to notice less vaginal dryness, itching, burning, or irritation within a few weeks. It may take several weeks of regular use, often around four weeks or longer, to experience a noticeable improvement. The exact response time depends on your symptoms, prescribed dose, treatment schedule, and individual response. Continue using the cream as directed, even if you do not notice an immediate benefit. Contact your healthcare provider if your symptoms do not improve, become worse, or return during treatment.
Premarin Vaginal Cream helps manage symptoms caused by low estrogen, but it does not permanently cure the underlying vaginal changes. After you stop treatment, symptoms such as vaginal dryness, burning, irritation, or pain during sex may gradually return. Stopping the cream is not generally expected to directly cause a sudden increase in blood pressure or an immediate rise in the risk of heart attack or stroke. However, estrogen therapy has important cardiovascular risks while it is being used because some estrogen is absorbed into the bloodstream. Speak with your healthcare provider before stopping treatment so they can review your symptoms and discuss other treatment options if needed.
No. Premarin Vaginal Cream is not suitable for everyone. Some estrogen can enter the bloodstream even though the medication is applied inside the vagina. Therefore, the warnings and precautions associated with systemic estrogen therapy must still be considered. Before using the cream, tell your healthcare provider about your complete medical history and every medication or supplement you take. Premarin Vaginal Cream may not be appropriate if you have unexplained vaginal bleeding, certain estrogen-sensitive cancers, blood clots, a previous heart attack or stroke, liver disease, a clotting disorder, or an allergy to any ingredient in the product. Your healthcare provider will consider your symptoms, age, medical history, and individual risk factors. The medication should generally be used at the lowest effective dose for the shortest period appropriate for your treatment needs.
Premarin Vaginal Cream is intended for symptoms related to menopause and should not be used during pregnancy. Tell your healthcare provider immediately if you become pregnant or think you may be pregnant while using it. Estrogens can pass into breast milk and may reduce the amount or quality of breast milk. Speak with your healthcare provider before using Premarin Vaginal Cream while breastfeeding. They will help you decide whether to avoid the medication, stop breastfeeding, or use a different treatment based on your individual needs. Do not begin, stop, or change your treatment without speaking with your healthcare provider.
| Generic name: | Conjugated Estrogen |
|---|---|
| Formulation: | Cream |
| Strength(s): | 0.625mg |
| Quantities Available: | 14grams, 28grams, 42grams |
Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.
Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies.
When ordering Premarin Vaginal Cream (conjugated estrogens) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is convenient for managing ongoing treatment without frequent refills.
Here’s what you need to know:
Dosage and Quantity: Premarin Vaginal Cream is available in a 30-gram tube, which contains 0.625 mg of conjugated estrogens per gram. The typical regimen involves using 0.5 grams daily for the first 2 weeks, followed by 0.5 grams twice weekly for maintenance.
7 grams (initial treatment) + 10 grams (maintenance) = 17 grams, therefore, for a 90-day supply, you would order one tube of Premarin Vaginal Cream.
No, we do not sell conjugated estrogens directly on our website. However, you can still enjoy competitive prices on Premarin Vaginal Cream, which contains conjugated estrogens as an active ingredient. To purchase Premarin Vaginal Cream from us, you will need a valid prescription from your healthcare provider. We require this prescription to dispense the medication safely and legally. You have the option to submit your prescription by mail, fax, or upload it through your online account for convenient processing.
Yes, we ship Premarin Vaginal Cream (conjugated estrogen) to both the United States and Puerto Rico.
Watch how Online Pharmacies Canada is helping customers save money on their medications.
Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Premarin Vaginal Cream (Conjugated Estrogen). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Premarin Vaginal Cream (Conjugated Estrogen).
REVIEWS