Premarin Vaginal Cream (Conjugated Estrogen) Shopper Approved

Prescription Prescription Required FormationFormulation: Cream

Premarin Vaginal Cream

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Prescription Prescription Required FormationFormulation: Cream

Conjugated Estrogen

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Premarin (conjugated estrogens) Vaginal Cream is a prescription medication used to treat vaginal symptoms of menopause, including moderate to severe painful intercourse caused by menopausal changes in the body such as vaginal dryness/burning/itching. It is a female hormone and is considered an effective treatment for atrophic vaginitis, a condition common in postmenopausal women.

Premarin vaginal cream is a prescription medication used to treat certain symptoms of menopause, including vaginal dryness and painful sex. It is indicated to relieve moderate to severe painful intercourse due to menopause.

Uses and Dosage

To use Premarin (conjugated estrogens) Vaginal Cream, the cream should be administered intravaginally using a special applicator that comes with the medication. Here are the general steps for using the cream:

  1. Wash your hands thoroughly with soap and warm water.
  2. Remove the cap from the tube of Premarin Vaginal Cream.
  3. Screw the applicator onto the tube.
  4. Squeeze the cream from the tube into the applicator until it is filled to the prescribed dosage level.
  5. Disconnect the applicator from the tube and replace the cap on the tube.
  6. Lie on your back with your knees bent or stand with one foot on a chair.
  7. Insert the filled applicator high into the vagina and press the plunger to release the cream.
  8. Gently remove the applicator and dispose of it properly.

It is generally administered intravaginally in a cyclic regimen daily for 21 days and then off for 7 days, with a starting dosage of 0.5 g and may be adjusted based on individual response.

Side Effects

Common Side Effects of Premarin Vaginal Cream (Conjugated Estrogen):

  • Bloating
  • Headache
  • Nausea
  • Vomiting
  • Dizziness
  • Stomach cramps
  • Changes in appetite
  • Weight changes
  • Breast pain, tenderness, or swelling

Serious Side Effects of Premarin Vaginal Cream (Conjugated Estrogen)

  • Depression, memory loss, or any changes in mood and behavior
  • Increased vaginal irritation
  • Unusual vaginal bleeding
  • Breast lumps
  • Persistent nausea and vomiting
  • Severe abdominal pain
  • Swelling of the ankles and feet
  • Severe headache
  • Confusion
  • Chest pain
  • Unusual sweating
  • Sudden vision changes
  • Tingling sensation or numbness in the arms and legs
  • Trouble breathing
  • Severe dizziness
  • Fainting

Allergic Reactions of Premarin Vaginal Cream

  • Breathing difficulty
  • Hives
  • Itching
  • Persistent dizziness
  • Rashes
  • Swelling of the face and neck
  • Wheezing

Form and Strength

Premarin Vaginal Cream (Conjugated Estrogen) is available in the following forms and strengths:

Premarin Vaginal Cream: Cream

  • 0.625mg


  • Do not use it if you have abnormal vaginal bleeding, past or present history of cancer, heart attack or stroke, blood clots, liver problems, or if you are allergic to any of its ingredients. Use caution and consult with your doctor if you have a bleeding disorder or suspect you may be pregnant.
  • Premarin vaginal cream may contain inactive ingredients that can cause allergic reactions or other complications, so it is important to talk to your pharmacist about any concerns.
  • Women with a uterus are often recommended to use progestin along with the cream to reduce the risk of uterine cancer.
  • Inform your healthcare provider immediately if you experience any unusual vaginal bleeding while using the cream.
  • Regular follow-up with your doctor is recommended when using vaginal cream, rings, or tablets containing only estrogen.

Frequently Asked Questions (FAQ)

How long before Premarin Vaginal Cream takes effect?

This topical medication for symptoms of menopause may not work right away. It may start to relieve vulvar or vaginal dryness, irritation, and itching after four weeks of use.

What happens when you stop using Premarin Vaginal Cream?

Once you stop using this vaginal cream, the symptoms of menopause may return. In some cases, women are also left with a rise in blood pressure and a moderate increase in the risk of stroke or heart attack.

Is Premarin Vaginal Cream safe for everyone to use?

No, Premarin Vaginal Cream may not be safe for everyone to use. Talk to your doctor about your medical history and any medications you are currently taking before using Premarin Vaginal Cream.

Can Premarin Vaginal Cream be used during pregnancy or while breastfeeding?

No, Premarin Vaginal Cream should not be used during pregnancy or while breastfeeding.


Additional information

Generic name:

Conjugated Estrogen





Quantities Available:



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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Premarin Vaginal Cream (Conjugated Estrogen). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Premarin Vaginal Cream (Conjugated Estrogen).