Indications
Cetrotide, which is a brand name for cetrorelix acetate, is a medication used in fertility treatments, particularly during in vitro fertilization (IVF), to prevent premature ovulation. Along with other hormones like follicle-stimulating hormone (FSH) and human chorionic gonadotropin (hCG), cetrorelix works by blocking the release of luteinizing hormone, thus preventing premature ovulation.
Cetrotide is given along with other fertility medications during controlled ovarian stimulation to inhibit premature LH (Luteinizing Hormone) surges in women undergoing fertility treatment. In this way, Cetrotide allows the eggs to mature properly and increases the chances of successful fertilization.
Uses and Dosage
To use Cetrotide, follow the instructions provided by your healthcare provider. The contents of one vial (0.25 mg Cetrotide) are injected subcutaneously once per day, at around the same time each day, with 24 hours between each dose. Here are the general steps for using a Cetrotide vial:
- Take a prefilled syringe and attach the yellow mixing needle.
- Flip the plastic cover off the medication vial and use an alcohol swab to clean the rubber stopper.
- Inject the contents of one vial (0.25 mg Cetrotide) subcutaneously.
Rotate injection sites to avoid irritation or discomfort at the injection site. Be sure to talk to your healthcare provider if you have any questions or concerns about using Cetrotide.
Cetrotide is typically administered as a subcutaneous injection once per day, with 24 hours between each dose. The usual dosage of Cetrotide is 0.25 mg subcutaneously once per day.
Side Effect
Common Side Effects of Cetrotide (Cetrorelix):
- Bruising
- Headache
- Itching
- Nausea
- Redness
- Swelling where the medicine was injected
Serious Side Effects of Cetrotide (Cetrorelix):
- Bloating
- Diarrhea
- Little or no urination
- Nausea
- Pain when you breathe
- Rapid heart rate
- Rapid weight gain, especially in your face and midsection
- Shortness of breath
- Stomach pain
- Vomiting
Form and Strength
Cetrotide (Cetrorelix) is available in the following forms and strength:
Cetrotide: Vial
- 0.25 mg
Caution
- Cases of hypersensitivity reactions, including anaphylactoid reactions with the first dose, have been reported during post-marketing surveillance. Patients should be monitored closely for signs of allergic reactions and should seek medical attention immediately if such reactions occur.
- OHSS (Ovarian Hyperstimulation Syndrome), a potentially life-threatening condition, may occur with the use of Cetrotide and other fertility treatments. Patients should be monitored closely for signs of OHSS, such as abdominal pain, bloating, and nausea. If OHSS occurs, treatment may need to be discontinued and patients may need to be hospitalized.
- Fertility treatments, including Cetrotide, may increase the risk of multiple pregnancies (twins, triplets, etc.), which can increase the risk of complications for both the mother and the fetuses.
- Patients with certain medical conditions, such as asthma, epilepsy, or migraines, may be more susceptible to side effects from Cetrotide and other fertility treatments. Patients should inform their healthcare provider of any pre-existing medical conditions before starting treatment.
- Cetrotide may interact with other medications, so it is important to inform your healthcare provider about any other medications you are taking before starting Cetrotide.
Frequently Asked Questions (FAQ)
How long do you take Cetrotide during IVF treatment?
The duration of Cetrotide treatment can vary depending on the individual's response to ovarian stimulation treatments, but it is typically used for 4-10 days.
Can Cetrotide be used during pregnancy?
No, Cetrotide should not be used during pregnancy as it is only intended for use during fertility treatments to prevent premature ovulation.
Can men use Cetrotide?
No, Cetrotide should not be used by men as it is only intended for use during fertility treatments in women.
How should Cetrotide be stored?
Cetrotide should be stored in the refrigerator (2-8°C) until it is ready to be used. It should not be frozen and should be protected from light.
Does Cetrotide have any drug interactions?
Cetrotide may interact with other medications, so it is important to inform your healthcare provider about any other medications you are taking before starting Cetrotide.
Resources
- https://www.webmd.com/drugs/2/drug-20403/cetrotide-subcutaneous/details
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021197s010lbl.pdf
- https://www.emdserono.com/us-en/pi/cetrotide-pi.pdf
- https://www.rxlist.com/cetrotide-drug.htm
- https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=aca7768e-28a7-4027-b1d8-e66247665f79
- https://www.goodrx.com/cetrotide/what-is
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