Fosamax Plus D (Alendronate/Vitamin D3)

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Fosamax Plus D Brand
Dosage Quantity & Price
Alendronate/Vitamin D3 (Generic alternate to Fosamax Plus D) Generic
Dosage Quantity & Price
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Fosamax plus D is a prescription medication used to treat or prevent osteoporosis, a condition in which bones become weak and more likely to break. It contains a combination of two active ingredients: alendronate and cholecalciferol (vitamin D3).

Fosamax Plus D is a combination of alendronate and cholecalciferol. Alendronate is part of a class of drugs called bisphosphonates, which work by preventing bone breakdown and increasing bone density. This slows bone loss and helps maintain strong bones, reducing the risk of fractures. Cholecalciferol is a form of vitamin D that helps the body absorb calcium, which is important for bone health. By combining these two medications, Fosamax plus D can slow bone loss and help the body build new bone.

Use and Dosage

Fosamax plus D comes in tablet form and is usually taken once a week unless otherwise directed by a doctor. It should be taken by mouth, after getting up for the day, and before taking any food or drink, other medications, or supplements.

Take Fosamax plus D with a full glass of plain water and swallow the tablet whole. Chewing or crushing the tablet should be avoided. After taking the medication, stay upright (sitting, standing, or walking) for at least 30 minutes and to avoid lying down until after the first food of the day. The medication works only if taken on an empty stomach.

Some medications, supplements, and foods can interfere with the absorption of Fosamax plus D, discuss with a doctor or pharmacist before taking any other medication or supplement while on Fosamax plus D. Additionally, the medication should be taken regularly on the same day each week to get the most benefit from it. Discuss the risks and benefits of the long-term use of Fosamax plus D with a doctor.

Side Effects

Common Side Effects of Fosamax Plus D (Alendronate/Vitamin D3):

  • Constipation
  • Diarrhea
  • Gas
  • Headache
  • Mild heartburn
  • Mild joint or back pain
  • Stomach upset

Serious Side Effects of Fosamax Plus D (Alendronate/Vitamin D3):

  • Chest pain
  • Difficulty breathing
  • Difficulty or pain when swallowing
  • Hives
  • Jaw pain
  • New or unusual pain in your thigh or hip
  • New or worsening heartburn
  • Numbness
  • Pain or burning under the ribs or in the back
  • Severe dizziness
  • Severe joint bone or muscle pain
  • Swelling
  • Swelling of your face lips tongue or throat

Forms and Strength

Fosamax plus D (Alendronate/Vitamin D3) is available in the following forms and strength:

Fosamax Plus D: Tablet

  • 70mg/2800IU
  • 70mg/5600IU

Alendronate/Vitamin D3: Tablet

  • 70mg/2800IU


  • Esophagus problems: The medication can cause irritation or inflammation of the esophagus, which can lead to esophagus problems such as difficulty swallowing, chest pain, and heartburn.
  • Jaw problems: In rare cases, Fosamax plus D can cause a serious condition called osteonecrosis of the jaw, which is characterized by jaw pain, swelling, or infection.
  • Unusual thigh bone fractures: Long-term use of bisphosphonate medicines like alendronate (one of the active ingredients in Fosamax plus D) may increase the risk of unusual fractures of the thigh bone.
  • Electrolyte imbalances: Vitamin D can increase calcium absorption in the body, which may lead to elevated levels of calcium in the blood (hypercalcemia) and other electrolyte imbalances.
  • Allergic reactions: Some people may be allergic to the active ingredients in Fosamax plus D or to other components of the medication.
  • Kidney disease: Fosamax Plus D should be used with caution in people with kidney disease, as it can affect kidney function.
  • Liver disease: The medication should be used with caution in people with liver disease, as it can affect liver function.
  • Pregnancy and breastfeeding: Fosamax Plus D may not be safe to use during pregnancy or while breastfeeding. Discuss the potential risks and benefits with a healthcare provider.
  • Interactions with other medications: Fosamax plus D may interact with some medications, including antacids, calcium supplements, and certain antibiotics. Discuss all medications and supplements with a healthcare provider before starting treatment with Fosamax Plus D.

Frequently Asked Questions (FAQ)

How long Fosamax plus D should be taken?

The length of treatment with Fosamax plus D will depend on individual factors and the condition being treated. Follow your healthcare provider's instructions.

Can Fosamax plus D be taken with other medications?

Fosamax plus D may interact with some medications, so discuss all medications and supplements with a healthcare provider before starting treatment.

Can Fosamax plus D cause weight gain?

Weight gain is not a common side effect of Fosamax Plus D. However, some people may experience changes in appetite or digestive issues such as bloating or gas.

Can Fosamax plus D prevent osteoporosis?

Fosamax plus D is used to treat or prevent osteoporosis, but its effectiveness will depend on individual factors and the condition being treated.


It's important to purchase Fosamax Plus D from verified Canadian pharmacy.

Additional information

Generic name:

Alendronate/Vitamin D3




70mg/2800IU, 70mg/5600IU

Quantities Available: