Indications
Treximet is oral medication indicated to treat migraine headaches with or without aura in adults. Treximet contains two active ingredients, sumatriptan succinate and naproxen sodium.
Sumatriptan is a triptan medication. It works by narrowing blood vessels in the brain to relieve the pain and other symptoms of migraine headaches. Naproxen belongs to the class of nonsteroidal anti-inflammatory drugs (NSAIDs) that work by reducing inflammation and pain in the body. The combination of these two drugs provides effective relief from migraine headaches.
Uses and Dosage
Treximet is a tablet that should be taken by mouth at the first sign of a migraine. You should take it as directed by your doctor, with a full glass of water (8 ounces/240 milliliters). To prevent stomach upset, take Treximet with food, milk, or an antacid. Do not break, crush, or chew the tablet.
The dosage of Treximet is determined by your medical condition, age, and response to treatment. If your symptoms do not improve, do not take additional doses of Treximet before consulting your doctor. If your symptoms are only partially relieved, or if your headache returns, you can take another dose at least two hours after the first dose. You should not take more than two doses of Treximet in a 24-hour period.
The recommended dosage of Treximet for adults with migraine is one 85-mg sumatriptan/500-mg naproxen tablet. It is usually taken at the start of a migraine headache and may be repeated once after two hours if the headache does not go away. The maximum dosage for adults is two tablets per day but the second tablet can be taken two hours after the first tablet if needed. The recommended dosage for children ages 12 years and older is one 85-mg/500-mg tablet
If you use drugs for migraine attacks on 10 or more days each month, the drugs may make your headaches worse. This is called medication overuse headache. Do not use medications more frequently or for longer than prescribed. Inform your doctor if you need to use Treximet more often, or if it is not working well, or if your headaches worsen.
Side Effect
Common Side Effects of Treximet (Sumatriptan Succinate/Naproxen Sodium):
- "Pins and needles" feeling
- Chest pain/discomfort
- Dizziness
- Dry mouth
- Hot flashes
- Indigestion
- Muscle tightness
- Nausea
- Neck, throat, or jaw pain, tightness, or pressure
- Sleepiness
Serious Side Effects of Treximet (Sumatriptan Succinate/Naproxen Sodium):
- Heart and blood vessel problems, including:
- Abnormal heart rhythm or heartbeat
- Heart failure and fluid buildup
- High blood pressure
- Risk of serious heart and blood vessel problems
- Allergic reaction
- Anemia (low levels of red blood cells)
- Blood flow problems in your bowels or blood vessels
- Blood flow problems in your feet or legs
- Kidney problems
- Liver problems
- Medication overuse headache
- Raynaud’s syndrome (problems with blood flow to your toes or fingers that causes changes in color or feeling)
- Risk of digestive system problems
- Seizure
- Serotonin syndrome
Form and Strength
Treximet (Sumatriptan Succinate/Naproxen Sodium) is available in the following forms and strength:
Sumatriptan Succinate/Naproxen Sodium: Tablet
- 85/500mg
Caution
- Cardiovascular risk: Treximet may increase the risk of serious cardiovascular events such as heart attack, stroke, and blood clots. It should be used with caution in patients with a history of cardiovascular disease or risk factors for cardiovascular disease.
- Gastrointestinal risk: Treximet may increase the risk of gastrointestinal complications such as bleeding, ulceration, and perforation of the stomach or intestines. It should be used with caution in patients with a history of gastrointestinal bleeding or ulceration, or in patients taking other medications that increase the risk of gastrointestinal bleeding.
- Renal risk: Treximet may cause or worsen kidney problems. It should be used with caution in patients with a history of kidney disease or in patients taking other medications that affect the kidneys.
- Pregnancy and breastfeeding: Treximet is not recommended for use during pregnancy or breastfeeding, as it may harm the fetus or nursing infant.
- Allergic reactions: Treximet may cause allergic reactions in some patients, including anaphylaxis, hives, and swelling of the face, lips, tongue, or throat. Patients with a history of allergic reactions to aspirin or other NSAIDs may be at higher risk.
- Liver problems: Treximet may cause liver problems, including liver failure, in rare cases. It should be used with caution in patients with liver disease or in patients taking other medications that affect the liver.
- Central nervous system effects: Treximet may cause dizziness, drowsiness, or other central nervous system effects. Patients should not drive or operate heavy machinery until they know how Treximet affects them.
- Pediatric use: Treximet is only approved for use in pediatric patients 12 years of age and older. It should not be used in younger patients.
Frequently Asked Questions (FAQ)
Is Treximet a prescription medication?
Yes, Treximet is a prescription medication and should only be used under the supervision of a healthcare professional.
How often can I take Treximet?
You can take Treximet or other migraine medications up to 9 days per month. Overusing migraine medications (taking them more than 9 days per month) can cause your headaches to get worse, leading to medication overuse headaches.
How long does it take for Treximet to work?
It comes in tablet form and is administered by mouth. Treximet generally begins to work within 2 hours. It is intended to reduce acute migraine symptoms of migraine attacks that have already begun.
Resources
- https://www.healthline.com/health/drugs/treximet-side-effects#serious-side-effects
- https://clinicaltrials.gov/ct2/show/NCT00240630
- https://www.medicalnewstoday.com/articles/treximet
- https://www.goodrx.com/treximet/what-is#faqs
- https://www.webmd.com/drugs/2/drug-150380/treximet-oral/details
- https://www.drugs.com/treximet.html
- https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=42ddf376-8dc0-4236-be2a-0c6ae92ece04
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