Migranal Nasal Spray (Dihydroergotamine)

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Migranal Nasal Spray Brand
Dosage Quantity & Price
Dihydroergotamine (Generic alternate to Migranal Nasal Spray) Generic

We don't sell this generic-version medication.

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Table of contents:

Migranal nasal spray is a medication used to treat migraine headaches in adults. It helps relieve headache pain and other symptoms such as sensitivity to light or sound. Proper treatment allows you to get back to your normal routine sooner and may decrease your need for other pain medications.

Migranal contains dihydroergotamine mesylate as its active ingredient. Dihydroergotamine belongs to a class of drugs known as ergot alkaloids. It may work by narrowing the blood vessels in the brain. It may also block other pain pathways in the brain.

Migranal nasal spray is available by prescription only and is contraindicated for individuals with a history of heart or blood vessel disease, uncontrolled high blood pressure, blood circulation problems, or who have used certain medications within the past 24 hours. It is administered intranasally, and the recommended dose is one spray into each nostril.

Use and Dosage

Migranal Nasal Spray is designed to be used in individual nasal spray vials. Each vial contains enough medication to treat a single migraine attack, and no more than 4 sprays should be used for a single attack. To prime the pump, spray it 4 times into the air, away from the face, before using each nasal spray vial.

To use Migranal Nasal Spray, at the first sign of a migraine, spray Migranal into both nostrils. One spray should be used in each nostril. Do not tilt your head back, sniff through your nose, or blow your nose while spraying or immediately after. A second dose should be used 15 minutes after the first spray, or as directed by your doctor. After using the medication, lie down and relax in a quiet, darkened room.

The maximum number of sprays for a single attack is 4 (two in each nostril), and you should feel some relief within 30 minutes of using this medication. The dosage is based on your medical condition and response to treatment, so ask your doctor how often you can use this medication to treat your migraine headaches. Do not increase your dose or use this drug more frequently or for a longer period than prescribed.

Migranal Nasal Spray works best if used at the first signs of a headache. If you wait until the headache worsens, the medication may not work as effectively. Additionally, it is not intended for long-term daily use.

Side Effects

Common Side Effects of Migranal Nasal Spray (Dihydroergotamine):

Serious Side Effects of Migranal Nasal Spray (Dihydroergotamine):

  • Anxiety
  • Blurred vision
  • Buzzing in your ears
  • Chest pain
  • Chest pain or heavy feeling
  • Confusion
  • Diarrhea that may be bloody
  • Difficulty breathing
  • General ill feeling
  • Hives
  • Muscle pain in your arms or legs
  • Nausea
  • Numbness or tingling
  • Pain spreading to the jaw or shoulder
  • Pale or blue-colored appearance in your fingers or toes
  • Problems with vision or balance
  • Seizure
  • Severe headache
  • Shortness of breath
  • Slurred speech
  • Stomach cramps
  • Sudden numbness or weakness (especially on one side of the body)
  • Sudden severe headache
  • Sweating
  • Swelling of your face lips tongue or throat
  • Swelling or itching in any part of your body
  • Uneven heartbeats
  • Weakness of the legs

Forms and Strength

Migranal Nasal Spray (Dihydroergotamine) is available in the following forms and strength:

Migranal Nasal Spray: Nasal spray ampule

  • 4mg/mL


  • Migranal Nasal Spray is contraindicated for use in individuals with a history of heart or blood vessel disease, uncontrolled high blood pressure, blood circulation problems, or who have used certain medications within the past 24 hours.
  • Dihydroergotamine should not be used for chronic daily headaches or prophylaxis of migraine headaches.
  • Migranal Nasal Spray should be used with caution in patients with hepatic or renal impairment.
  • Migranal may interact with other medications, discuss all medications with a healthcare provider before using Migranal Nasal Spray.
  • Dihydroergotamine may cause side effects such as nausea, vomiting, dizziness, or nasal discomfort. If these symptoms persist, medical attention should be sought.
  • Migranal should not be used during pregnancy or breastfeeding unless the potential benefits outweigh the potential risks to the fetus or infant.
  • It should not be used by individuals who are taking certain medications, such as protease inhibitors or macrolide antibiotics.
  • Migranal may cause a decrease in blood pressure, so caution should be exercised in patients with hypotension or who are taking medications that may lower blood pressure.
  • Dihydroergotamine may cause a rebound headache if used too frequently or for a prolonged period.
  • Dihydroergotamine may cause an allergic reaction in some individuals, so caution should be exercised in patients with a history of allergies to ergotamine or any of the components of Migranal Nasal Spray.

Frequently Asked Questions (FAQ)

Can Migranal Nasal Spray be used for menstrual migraines?

Yes, Migranal Nasal Spray can be used for menstrual migraines. However, talk to your healthcare provider about the appropriate dosage and timing of administration to get the maximum benefit from the medication.

How often can I use Migranal Nasal Spray?

The usual dose of Migranal Nasal Spray is one spray in each nostril. It can be repeated after 15 minutes if necessary. However, Migranal Nasal Spray should not be used more than two times in 24 hours.

Can Migranal Nasal Spray be used with other migraine medications?

Migranal Nasal Spray can be used with other migraine medications but talk to your healthcare provider about any potential drug interactions before using it.

Is Migranal Nasal Spray addictive?

No, Migranal Nasal Spray is not addictive. However, use it only as prescribed and under the guidance of a healthcare professional.

Can Migranal Nasal Spray cause rebound headaches?

Yes, overuse of Migranal Nasal Spray can cause rebound headaches. Use it only as prescribed and not to exceed the recommended dosage or frequency of administration.


It's important to purchase Migranal Nasal Spray from verified Canadian pharmacy.

Additional information

Generic name:



Nasal spray ampule



Quantities Available:

6mL, 18mL