Dizziness, Fatigue, and Other Common Side Effects
Trandate can cause side effects such as:
- Dizziness
- Lightheadedness
- Tiredness
- Headache
- Nausea
- Vomiting
- Diarrhea
These effects may be more noticeable when treatment is first started or when the dose is increased.
Stand up slowly from a sitting or lying position to reduce the risk of dizziness or fainting.
Low Blood Pressure
Trandate can lower blood pressure too much, especially after a dose increase or when it is given intravenously in a hospital.
Symptoms of low blood pressure may include dizziness, weakness, fainting, or blurred vision.
Your healthcare provider may monitor your blood pressure closely during treatment.
Asthma and Other Breathing Problems
Because labetalol blocks beta receptors, it can sometimes worsen breathing problems.
Tell your healthcare provider if you have:
- Asthma
- Severe chronic obstructive pulmonary disease
- Wheezing
- Another bronchospastic lung condition
Trandate may not be appropriate in some people with these conditions.
Certain Heart Conditions
Trandate should be used carefully, or avoided, in people with certain heart problems.
These may include:
- Heart block greater than first degree
- Cardiogenic shock
- Severe or uncontrolled heart failure
- A very slow heartbeat
Your healthcare provider will determine whether Trandate is appropriate based on your heart condition and overall health.
Liver Problems
Labetalol has been associated with rare but serious liver injury.
Tell your healthcare provider if you have liver disease before starting Trandate.
Contact your healthcare provider promptly if you develop:
- Yellowing of the skin or eyes
- Dark urine
- Severe tiredness
- Persistent nausea
- Upper abdominal pain
Your healthcare provider may order liver function tests if needed.
Kidney Problems
Tell your healthcare provider if you have kidney disease.
A routine dose adjustment is not always required solely because of kidney impairment, but your blood pressure, kidney function, and overall response to treatment may need closer monitoring.
Diabetes and Low Blood Sugar
Trandate can make some warning signs of low blood sugar harder to recognize.
For example, it may reduce or mask the usual fast heartbeat that can occur with hypoglycemia.
If you have diabetes, monitor your blood sugar as directed and watch for other symptoms such as sweating, hunger, weakness, dizziness, or confusion.
Pregnancy
Labetalol is commonly used to treat high blood pressure during pregnancy when a healthcare provider determines that treatment is appropriate.
However, like all medications used during pregnancy, the benefits and potential risks should be considered carefully.
Tell your healthcare provider if you are pregnant, planning to become pregnant, or become pregnant while taking Trandate.
Breastfeeding
Labetalol can pass into breast milk in small amounts.
Tell your healthcare provider if you are breastfeeding or planning to breastfeed.
Your healthcare provider can help determine whether Trandate is appropriate and whether your baby needs any monitoring.
Severe Allergic Reactions
People with a history of severe allergic reactions may respond differently to epinephrine while taking a beta blocker such as labetalol.
This can make some allergic reactions more difficult to treat.
Tell your healthcare provider if you have a history of anaphylaxis or severe allergies.
Seek emergency medical attention if you develop swelling of the face or throat, difficulty breathing, hives, or another serious allergic reaction.
Drug Interactions
Trandate can interact with other medications.
Tell your healthcare provider about all prescription medications, over-the-counter products, vitamins, supplements, and herbal products you use.
Particular caution may be needed with:
- Other blood pressure medications
- Certain heart medications
- Some antidepressants
- Insulin and other diabetes medications
- Medications that slow the heart rate
Do not start, stop, or change another medication without first checking with your healthcare provider or pharmacist.
Do Not Stop Trandate Suddenly
Do not suddenly stop taking Trandate unless your healthcare provider tells you to.
Abruptly stopping a beta blocker may cause blood pressure to rise quickly and may worsen certain heart problems.
Your healthcare provider may gradually reduce your dose when treatment needs to be stopped.
Regular Monitoring
During treatment, your healthcare provider may monitor your:
- Blood pressure
- Heart rate
- Liver function
- Kidney function
- Blood sugar, if you have diabetes
Regular monitoring helps make sure Trandate remains safe and effective for you.
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