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Trandate (generically known as labetalol) is a prescription medication used to treat high blood pressure (hypertension). It belongs to a group of medications called beta blockers, which work by blocking the effect of certain hormones on the heart and blood vessels. This causes the heart to beat more slowly and with less force, which lowers blood pressure.

Labetalol typically starts to work after about 2 hours, but it may take several days before patients experience the full benefits of the medication.

Uses and Dosage

Trandate is available in both tablets to be taken orally usually twice a day or directed by a doctor. It can be taken with or without food. Follow the doctor's instructions carefully and use Trandate regularly to get the most benefit from the medication. To help remember to take it, patients should take it at the same time each day. Overall, patients should always talk to their doctor about all potential risks and benefits of taking Trandate before starting treatment and should follow their doctor's instructions carefully while taking the medication.

For the treatment of high blood pressure, it may take several weeks before patients experience the full benefit of Trandate. Even if patients feel well, keep taking the medication as directed by the doctor. If there is no improvement in blood pressure readings or if they worsen, patients should inform their doctor.

The dosage is determined based on a patient's medical condition and response to treatment, and doctors may start with a low dose and gradually increase it to reduce the risk of side effects. Patients should take Trandate at the same time each day to ensure consistent dosing. However, the initial recommended dosage is 100mg twice daily for adults, whether used alone or added to a diuretic regimen, and may be increased by 100mg every 2-3 days. The usual dosage range is 200-400mg twice daily, not to exceed 2400mg/day.

Side Effect

Common Side Effects of Trandate (Labetalol):

  • Dizziness
  • Drowsiness
  • Nausea
  • Numbness
  • Skin redness
  • Sudden warmth
  • Sweating
  • Tingly feeling in your scalp
  • Tiredness
  • Vomiting

Serious Side Effects of Trandate (Labetalol):

  • Blurred vision
  • Dark urine and
  • Fainting
  • Flu-like symptoms
  • Itching
  • Lightheadedness
  • Loss of appetite
  • Pounding in your neck or ears
  • Rapid weight gain
  • Severe headache
  • Shortness of breath
  • Slow breathing
  • Slow heart rate
  • Stomach pain (upper right side)
  • Swelling
  • Weak pulse
  • Yellowing of the skin or eyes (jaundice)

Form and Strength

Trandate (Labetalol) is available in the following forms and strength:

Trandate: Tablet

  • 100 mg
  • 200 mg
  • 400 mg

Labetalol: Tablet

  • 300 mg
  • 400 mg


  • Caution about side effects such as dizziness, lightheadedness, fatigue, nausea, vomiting, diarrhea, and headache.
  • Trandate should be used with caution in patients with asthma, severe obstructive lung disease, heart block greater than first degree, cardiogenic shock, or heart failure.
  • Patients with a history of liver or kidney disease may need a lower dose of Trandate or more frequent monitoring.
  • Trandate can cause hypotension (low blood pressure), especially when given intravenously, and patients should be monitored closely for this.
  • Trandate can cause fetal harm and should be used during pregnancy only if clearly needed.
  • Trandate can pass into breast milk and may harm a nursing baby, so women who are breastfeeding should talk to their doctor before taking this medication.
  • Trandate can mask symptoms of low blood sugar (hypoglycemia) in patients with diabetes and may make it more difficult to recognize and treat this condition.
  • Patients with a history of severe allergic reactions (anaphylaxis) should use Trandate with caution, as it may cause anaphylaxis or a similar allergic reaction in some patients.
  • Trandate may interact with other medications, including other blood pressure medications, certain antidepressants, and insulin, and patients should consult their doctor before taking any other medications while on Trandate.
  • Abruptly stopping Trandate can cause rapid increases in blood pressure, which can lead to serious complications. Therefore, patients should talk to their doctor before stopping Trandate or changing their dose.

Frequently Asked Questions (FAQ)

Can Trandate cause weight gain?

Weight gain is not a common side effect of Trandate, but it is possible.

How quickly does Trandate work?

The peak effects of Trandate usually occur within 2 to 4 hours of taking the medication.

Can Trandate be used to treat high blood pressure during pregnancy?

Trandate can be used during pregnancy only if clearly needed, as it can cause fetal harm.

Can Trandate be used to treat heart failure?

Trandate has not been approved by the FDA (Food and Drug Administration) for the treatment of heart failure, but it may be used off-label by some healthcare providers.


Additional information

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100mg, 200mg, 300mg, 400mg

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56, 90, 100


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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Trandate (Labetalol). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Trandate (Labetalol).