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Prescription Prescription Required FormationFormulation: Scored Tablet


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Prescription Prescription Required FormationFormulation: Scored Tablet


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ProAmatine (generically known as midodrine) is a medication used to treat symptoms of low blood pressure when standing, also known as orthostatic hypotension. Midodrine is a vasopressor and antihypotensive medication used to treat low blood pressure by stimulating nerve endings in blood vessels, causing the blood vessels to constrict and increase blood pressure.

Uses and Dosage

Midodrine is usually taken three times a day, during daytime hours at least 3 hours. Take the last daily dose of midodrine before an evening meal and at least 4 hours before bedtime. Take midodrine at the same time every day and follow the instructions on your prescription label carefully. Only take midodrine as directed by your doctor, and do not change the dosage or frequency of your dose.

Midodrine is intended for use during waking hours when you are upright. Avoid taking a dose if you will be lying down for a long time. Talk to your doctor about proper positioning when lying down, which may involve elevating the head of your bed.

Side Effect

Common Side Effects of Proamatine (Midodrine):

  • Chills
  • Dizziness
  • Goosebumps
  • Headache
  • Increased urination
  • Itching (especially in your scalp)
  • Nausea
  • Numbness
  • Painful or difficult urination
  • Sudden urge to urinate
  • Tingling
  • Tired feeling

Serious Side Effects of Proamatine (Midodrine):

  • Anxiety
  • Blurred vision
  • Buzzing in your ears
  • Chest pain
  • Confusion
  • Lightheadedness
  • Pounding sensation in your ears
  • Seizure
  • Severe dizziness
  • Severe headache
  • Shortness of breath
  • Uneven heartbeats
  • Weak pulse

Form and Strength

Proamatine (Midodrine) is available in the following forms and strength:

Midodrine: Tablet

  • 2.5mg
  • 5mg
  • 10mg


  • ProAmatine may cause supine hypertension, which is high blood pressure that occurs when lying down.
  • ProAmatine should not be used if you have severe organic heart disease, such as congestive heart failure.
  • It should be used with caution if you have kidney disease, liver disease, or urinary retention.
  • It may interact with other medications; inform your doctor of all medications you are taking.
  • ProAmatine is not recommended for use during pregnancy or breastfeeding. ProAmatine may cause dizziness, lightheadedness, or fainting, especially when standing up quickly. Do not drive, operate heavy machinery, or engage in activities requiring alertness until you know how the medication affects you.
  • ProAmatine may increase your heart rate, monitor your heart rate, and blood pressure while taking this medication.
  • ProAmatine may cause allergic reactions in some individuals. If you experience any symptoms of an allergic reaction, such as swelling, hives, or trouble breathing, seek medical attention right away.

Frequently Asked Questions (FAQ)

How long is midodrine active for?

The plasma levels of the prodrug peak after about half an hour, and decline with a half- life of approximately 25 minutes, while the metabolite reaches peak blood concentrations about 1 to 2 hours after a dose of midodrine and has a half-life of about 3 to 4 hours.

Can ProAmatine cause dependence or addiction?

No, ProAmatine is not known to cause dependence or addiction.

Can ProAmatine be taken with food or on an empty stomach?

ProAmatine can be taken with or without food, but it should be taken at least 30 minutes before a meal to work effectively.

How long does it take for ProAmatine to start working?

ProAmatine typically starts working within 30-60 minutes of taking it. It can provide symptom relief for up to 4 hours.

What should I do if I miss a dose of ProAmatine?

If you miss a dose of ProAmatine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.


Additional information

Generic name:



Scored Tablet, Tablet


2.5mg, 5mg, 10mg

Quantities Available:

100, 200, 300


Additional Information Book

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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Proamatine (Midodrine). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Proamatine (Midodrine).