Indications
Tasmar is an oral medication used in combination with other medications, such as carbidopa and levodopa, to reduce the symptoms of Parkinson's disease, such as tremors and stiffness. It contains the active substance tolcapone, which belongs to a class of drugs called COMT inhibitors. Tolcapone blocks a certain natural substance (COMT enzyme) that breaks down levodopa in the body.
Tasmar has a warning for a rare but potentially fatal acute liver injury, so it is only prescribed to patients with levodopa-responsive idiopathic Parkinson's disease who are not responding adequately to other treatments or in whom other treatments are not suitable. Tasmar is available in hexagonal tablets in different strengths, including 100mg.
Use and Dosage
Tasmar comes as an oral tablet that can be taken by mouth with or without food as directed by a healthcare professional, typically three times a day. Treatment usually begins with a low dose which may be increased by a healthcare professional after 3 weeks if they determine that a higher dose would be beneficial.
The recommended dose of Tasmar is 100 mg three times daily, always as an adjunct to levodopa/benserazide or levodopa/carbidopa therapy. The dosage may be increased to 200 mg three times daily after 3 weeks, with liver enzyme monitoring taking place before increasing the dose, as stated in the Tasmar product information. The dosage may vary depending on the patient's medical condition and response to therapy and should be determined by a healthcare professional.
Take Tasmar regularly at the same time each day to obtain the best results. Do not stop taking the medication unless directed to do so by a healthcare professional, as doing so may cause Parkinson's symptoms to worsen. Notify a healthcare professional if your condition persists or worsens.
Side Effects
Common Side Effects of Tasmar (Tolcapone):
- Confusion
- Diarrhea
- Dizziness
- Excessive dreaming
- Headache
- Involuntary movements
- Loss of appetite
- Low blood pressure
- Muscle contractions and cramps
- Nausea
- Sleep problems
- Sleepiness
Serious Side Effects of Tasmar (Tolcapone):
- Hallucinations
- Tiredness
- Fainting
- Stomach pain and upset stomach
- Vomiting
- Constipation
- Dry mouth
- Falling
- More sweating
- Bladder infection
- Common cold or flu
Forms and Strength
Tasmar (Tolcapone) is available in the following forms and strength:
Tasmar: Tablet
- 100mg
Cautions
- Tasmar may cause severe diarrhea, which can lead to dehydration, electrolyte imbalances, and other complications.
- Tasmar may interact with other medications, including certain antidepressants, antipsychotics, and medications that affect the liver or the immune system.
- Tasmar may increase the risk of developing neuroleptic malignant syndrome, a rare but serious condition characterized by fever, muscle rigidity, and mental status changes.
- Tasmar may cause confusion, hallucinations, and other psychiatric side effects, especially in elderly patients or patients with a history of psychiatric disorders.
- Patients taking Tasmar should be monitored regularly for signs of liver damage or other side effects, and treatment should be stopped immediately if any serious side effects occur. Discuss with a healthcare professional about any potential risks and side effects of Tasmar before starting treatment.
- One caution about Tasmar (Tolcapone) is that it has a warning for a rare but potentially fatal acute liver injury. Therefore, it should only be prescribed to patients with levodopa-responsive idiopathic Parkinson's disease who are not responding adequately to other treatments or in whom other treatments are not suitable.
- There is no information about the tolerability of Tolcapone in certain populations, including children, elderly patients, and patients with hepatic or renal impairment.
- Tasmar also contains lactose and sodium, which may cause problems in patients with lactose intolerance or on a sodium-restricted diet. Consult with a healthcare professional about the risks and benefits of taking Tasmar before starting treatment.
Frequently Asked Questions (FAQ)
Can Tasmar interact with other medications?
Yes, Tasmar may interact with other medications, such as certain antidepressants, antipsychotics, and medications that affect the liver or the immune system. Inform a healthcare professional about all medications you are taking before starting treatment with Tasmar.
How long does Tasmar take to work?
Tasmar may take several weeks to start working. Follow the dosing schedule prescribed by a healthcare professional and to not stop taking Tasmar abruptly without their guidance.
Can Tasmar be used in children?
The safety and effectiveness of Tasmar in children is not known. Tasmar is only approved for use in adults with Parkinson's disease.
What should I do if I miss a dose of Tasmar?
If you miss a dose of Tasmar, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not take a double dose to make up for a missed one.
Resources
- https://parkinsonsnewstoday.com/tasmar/
- https://www.drugs.com/mtm/tasmar.html
- https://www.webmd.com/drugs/2/drug-5882/tasmar-oral/details
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/020697s004lbl.pdf
- https://nurseslabs.com/antiparkinsonism-drugs/
- https://www.goodrx.com/tolcapone/what-is#side-effects
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