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Formulation: ER Tablet
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Synjardy XR contains two active ingredients: empagliflozin and metformin hydrochloride extended-release. It is a prescription medication used to help manage type 2 diabetes in adults.
Synjardy XR is used together with diet and exercise to help improve blood sugar control in adults with type 2 diabetes.
Type 2 diabetes occurs when the body does not use insulin effectively or does not make enough insulin to keep blood sugar within a healthy range.
Synjardy XR helps lower blood sugar in two different ways because it combines two diabetes medications with different actions.
The empagliflozin component of Synjardy XR may also help reduce certain cardiovascular risks in adults with type 2 diabetes.
It is indicated to help reduce the risk of cardiovascular death in adults with established cardiovascular disease.
For adults with type 2 diabetes and heart failure, empagliflozin can also help reduce the risk of cardiovascular death and hospitalization for heart failure.
Empagliflozin may also provide kidney-related benefits for certain adults with type 2 diabetes and chronic kidney disease who are at risk of disease progression.
It may help reduce the risk of:
Because Synjardy XR also contains metformin, it is only used for these indications in people who also have type 2 diabetes.
Empagliflozin belongs to a class of medications called sodium-glucose co-transporter 2 (SGLT2) inhibitors.
The kidneys normally filter glucose from the blood and then return much of it to the bloodstream.
Empagliflozin blocks the SGLT2 protein in the kidneys, which causes more glucose to leave the body through the urine.
This helps lower blood sugar levels.
Metformin belongs to a class of medications called biguanides.
It helps lower blood sugar mainly by:
Metformin does not usually cause the pancreas to release extra insulin on its own.
Empagliflozin and metformin lower blood sugar in different ways.
Using them together can provide better blood sugar control than either medication alone in some people.
The combination may also offer additional heart and kidney benefits from empagliflozin in appropriate patients.
Synjardy XR contains extended-release metformin, which means the medication is released gradually over time.
This allows Synjardy XR to generally be taken once daily, usually with a meal.
Synjardy XR should not be confused with regular Synjardy, which contains immediate-release metformin and has different dosing instructions.
Synjardy XR is intended for people with type 2 diabetes.
It is not recommended for improving blood sugar control in people with type 1 diabetes because empagliflozin can increase the risk of diabetic ketoacidosis.
Your healthcare provider will also consider your kidney function before prescribing Synjardy XR because the metformin component may not be appropriate when kidney function is significantly reduced.
Synjardy XR is an extended-release tablet taken by mouth once daily with a meal in the morning.
Taking it with food can help reduce stomach-related side effects from metformin, such as nausea or diarrhea.
Try to take Synjardy XR at about the same time each morning.
Swallow Synjardy XR tablets whole.
Do not:
Changing the tablet can interfere with the extended-release system and cause the medication to be released incorrectly.
There is no single starting dose that is right for everyone.
Your healthcare provider will choose your starting dose based on:
If you are switching from metformin alone, Synjardy XR is generally started with a similar total daily metformin dose plus 10 mg of empagliflozin per day.
If you are switching from empagliflozin alone, the starting regimen generally uses the same empagliflozin dose plus 1,000 mg of metformin per day.
If you already take both medications separately, Synjardy XR may be started at similar total daily doses of each ingredient.
Maximum empagliflozin dose: 25 mg per day.
Maximum metformin hydrochloride dose: 2,000 mg per day.
Your healthcare provider may increase the dose gradually, especially the metformin component, to reduce stomach-related side effects.
Synjardy XR tablets are available in several strengths, including:
Depending on the prescribed dose, you may need to take one or more tablets once daily.
Empagliflozin causes the kidneys to remove more glucose and water through the urine.
This can increase urination and may contribute to dehydration, especially during hot weather, illness, vomiting, or diarrhea.
Drink enough fluids unless your healthcare provider has told you to limit your fluid intake.
Your healthcare provider will check your kidney function before starting Synjardy XR and periodically during treatment.
Starting Synjardy XR is generally not recommended when the estimated glomerular filtration rate (eGFR) is below 45 mL/min/1.73 m² because of the metformin component.
Synjardy XR is contraindicated in severe kidney impairment with an eGFR below 30 mL/min/1.73 m².
If you miss a dose of Synjardy XR, take it as soon as you remember.
If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule.
Do not take two doses at the same time or take extra Synjardy XR to make up for a missed dose.
Take Synjardy XR every day as prescribed, even if you feel well.
Continue following the eating plan, physical activity routine, and blood sugar monitoring schedule recommended by your healthcare provider.
If your blood sugar remains consistently too high or too low, contact your healthcare provider. Your dose or overall diabetes treatment plan may need to be adjusted.
Synjardy XR (empagliflozin/metformin HCl) is available in the following forms and strengths:
The metformin in Synjardy XR can rarely cause lactic acidosis, a serious buildup of lactic acid in the blood.
This condition can be life-threatening and requires immediate medical attention.
Symptoms may include:
The risk is higher in people with severe kidney problems, liver disease, heavy alcohol use, dehydration, or certain other medical conditions.
Seek emergency medical attention if you develop symptoms that may suggest lactic acidosis.
The empagliflozin in Synjardy XR can increase the risk of ketoacidosis, a serious condition caused by a buildup of ketones in the blood.
Ketoacidosis can occur even when blood sugar is not extremely high.
Symptoms may include:
Stop Synjardy XR and seek medical attention right away if these symptoms occur.
Synjardy XR is not recommended for treating type 1 diabetes because the risk of ketoacidosis is higher.
Empagliflozin causes the kidneys to remove more glucose and water through the urine.
This can lead to dehydration or low blood pressure, especially in older adults, people with reduced kidney function, or people taking diuretics.
Symptoms may include:
Drink enough fluids unless your healthcare provider has told you to restrict your fluid intake.
Your kidney function should be checked before starting Synjardy XR and periodically during treatment.
Reduced kidney function can increase the risk of metformin-associated lactic acidosis and may also increase the risk of dehydration or other side effects from empagliflozin.
Tell your healthcare provider if you notice a significant decrease in urination, swelling, severe weakness, or other possible signs of kidney problems.
Empagliflozin can increase the risk of genital yeast infections.
Symptoms may include:
Contact your healthcare provider if you develop symptoms of a yeast infection.
Synjardy XR can increase the risk of urinary tract infections.
Some infections can become serious and spread to the kidneys or bloodstream.
Contact your healthcare provider if you develop:
Seek prompt medical care if symptoms are severe.
Rarely, SGLT2 inhibitors such as empagliflozin can cause a serious infection of the tissue around the genital and perineal area called Fournier’s gangrene.
Seek immediate medical attention if you develop pain, tenderness, redness, or swelling around the genitals or area between the genitals and anus, especially if you also have a fever or feel very unwell.
Synjardy XR by itself does not usually cause significant low blood sugar.
However, the risk of hypoglycemia may increase if it is taken with insulin or medications that stimulate insulin release.
Symptoms may include:
Your healthcare provider may need to lower the dose of insulin or another diabetes medication when Synjardy XR is started.
Long-term metformin use can lower vitamin B12 levels in some people.
Low vitamin B12 may cause symptoms such as:
Your healthcare provider may check your blood counts regularly and measure vitamin B12 levels periodically during long-term treatment.
Empagliflozin has been associated with reports of lower-limb complications.
Check your feet regularly and contact your healthcare provider if you notice:
Good foot care is especially important if you have diabetes-related nerve or circulation problems.
Serious allergic reactions can occur with Synjardy XR.
Seek immediate medical attention if you develop:
Stop the medication and seek urgent care if a serious allergic reaction is suspected.
Synjardy XR may need to be temporarily stopped before certain surgeries or procedures.
Periods of fasting, illness, dehydration, or reduced food intake can increase the risk of ketoacidosis or lactic acidosis.
Tell your healthcare provider that you take Synjardy XR before having surgery or a medical procedure.
Your healthcare provider may monitor:
Regular monitoring helps make sure Synjardy XR remains safe and effective for you.
Synjardy XR can be used safely in people with normal or mildly reduced kidney function, but kidney function needs to be checked before and during treatment. The empagliflozin in Synjardy XR increases urination, which can lead to fluid loss and dehydration. In some people, especially those who already have kidney problems or take medications such as diuretics, ACE inhibitors, ARBs, or NSAIDs, this may increase the risk of kidney-related side effects. Drink enough fluids unless your healthcare provider has told you to limit your fluid intake, and contact your healthcare provider if you develop severe dizziness, very little urination, or signs of dehydration.
Possibly, but it depends on how well your kidneys are working. Your healthcare provider will usually check your estimated glomerular filtration rate, or eGFR, before prescribing Synjardy XR and periodically during treatment. Synjardy XR should generally not be started if your eGFR is below 45 mL/min/1.73 m², and it is contraindicated if your eGFR is below 30 mL/min/1.73 m² because the metformin component can build up and increase the risk of lactic acidosis.
It is best to avoid excessive alcohol use while taking Synjardy XR. Alcohol can increase the effect of metformin on lactate metabolism, which may raise the risk of a rare but serious condition called lactic acidosis. Alcohol can also contribute to dehydration and may affect blood sugar control. Ask your healthcare provider how much alcohol, if any, is appropriate for you while taking Synjardy XR.
| Generic name: | Empagliflozin/Metformin, Empagliflozin/Metfromin hcl |
|---|---|
| Formulation: | ER Tablet |
| Strength(s): | 12.5/1000mg, 25/1000mg |
| Quantities Available: | 100, 180 |
Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.
Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies.
When ordering Synjardy XR (empagliflozin and metformin hcl) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is common for prescription medications to ensure adequate management of chronic conditions without frequent refills.
Here’s what you need to know:
Dosage and Quantity: Synjardy XR is commonly prescribed in dosages such as 12.5 mg/1,000 mg or 25 mg/1,000 mg, taken once daily. For a 90-day supply, this means you would order 90 tablets (90 days x 1 tablet per day).
We do not sell empagliflozin and metformin hcl directly, but you can still enjoy low prices on Synjardy XR, which contains empagliflozin and metformin hcl as active ingredients. You will need a valid prescription from your healthcare provider to purchase Synjardy XR. We require this to dispense the medication. You can mail, fax, or upload your prescription through your online account.
Yes, we ship Synjardy XR (empagliflozin/metfromin hcl) to both the United States and Puerto Rico.
Watch how Online Pharmacies Canada is helping customers save money on their medications.
Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Synjardy XR (Empagliflozin/Metfromin hcl). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Synjardy XR (Empagliflozin/Metfromin hcl).
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