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Prescription Prescription Required FormationFormulation: Capsule


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Prescription Prescription Required FormationFormulation: Capsule

Doxepin Hydrochloride

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Sinequan, also known as doxepin hydrochloride, is a medication primarily used to treat depression and anxiety. It is also used to treat insomnia and other mental/mood disorders. Doxepin belongs to the tricyclic antidepressant (TCA) class of drugs. Doxepin works by increasing the levels of certain chemicals in the brain that affect mood and behavior.

For hives, it is a less preferred alternative to antihistamines. It has a mild to moderate benefit for sleeping problems. It is used as a cream for itchiness due to atopic dermatitis or lichen simplex chronicus.

Uses and Dosage

Sinequan is available in capsule form, and the dosage and administration instructions are based on the patient's medical condition and response to treatment, as determined by their doctor. Generally, Sinequan is taken orally, usually 1 to 3 times daily or as directed by the doctor. If the patient takes it only once a day, it should be taken at bedtime to reduce daytime sleepiness. The medication should be taken regularly to get the most benefit from it, and the dosage should not be increased, or the drug used more often or for longer than prescribed.

To reduce the risk of side effects such as drowsiness, dry mouth, and dizziness, the doctor may direct the patient to start at a low dose and gradually increase it. The medication should be taken with water or milk and should not be mixed with soda or other carbonated beverages. If the patient is taking the medication in combination with liquid methadone, it may be mixed with lemonade, orange juice, sugar water, or plain water, but not grape juice.

Continue taking Sinequan even if the patient feels well, and to not stop taking the medication without consulting their doctor first. Suddenly stopping the medication may worsen certain conditions or cause withdrawal symptoms like mood swings, headaches, and tiredness. The doctor may gradually reduce the patient's dose to prevent these symptoms while stopping treatment.

It may take up to 3 weeks for the full effect of Sinequan to be felt, and any new or worsening symptoms should be reported to the doctor right away. As with all medications, follow the doctor's instructions carefully and report any concerns or side effects.

Side Effects

Common Side Effects of Sinequan (Doxepin Hydrochloride):

  • Blurred vision
  • Constipation
  • Diarrhea
  • Dizziness
  • Drowsiness
  • Dry mouth
  • Headache
  • Nausea
  • Trouble passing urine

Serious Side Effects of Sinequan (Doxepin Hydrochloride):

  • Changes in blood pressure
  • Rapid or worm-like movements of the tongue
  • Rapid weight gain
  • Redness of the face, neck, arms, and occasionally, upper chest
  • Restlessness
  • Ringing or buzzing or other unexplained noise in the ears
  • Skin rash
  • Sudden loss of consciousness
  • Sweating
  • Swelling of the face, ankles, or hands
  • Swollen glands
  • Unusual bleeding or bruising
  • Unusual tiredness or weakness
  • Vomiting
  • Vomiting of blood
  • Weight gain
  • Yellow eyes or skin

Form and Strength

Sinequan (Doxepin Hydrochloride) is available in the following forms and strengths:

Sinequan: Capsule

  • 10 mg
  • 25 mg
  • 50 mg
  • 100 mg

Doxepin Hydrochloride: Capsule

  • 25 mg
  • 75 mg


  • Sinequan may increase the risk of suicidal thinking and behavior in children, adolescents, and young adults. It is essential to monitor patients closely for clinical worsening, suicidal behavior, or unusual changes in behavior.
  • The medication may impair judgment, thinking, or motor skills. Patients should avoid driving, operating heavy machinery, or performing any activity that requires alertness until they know how Sinequan affects them.
  • Patients with a history of seizures, urinary retention, or narrow-angle glaucoma should use Sinequan with caution and at lower dosages, as the medication may aggravate these conditions.
  • Sinequan can cause anticholinergic side effects, such as dry mouth, constipation, blurred vision, urinary retention, and confusion, especially in elderly or sensitive patients.
  • Patients with a history of cardiovascular disease or recent myocardial infarction should be cautious when taking Sinequan due to its potential to cause arrhythmias or heart block.
  • Patients with a history of liver or kidney disease should use Sinequan with caution and at lower dosages because the medication may accumulate in their bodies, leading to toxicity.
  • Sinequan can interact with other medications or substances, such as central nervous system depressants, anticholinergics, or monoamine oxidase inhibitors (MAOIs), and cause adverse effects or reduced efficacy. Patients should inform their doctor before starting or stopping any medications or supplements.
  • Sinequan may cause withdrawal symptoms if the medication is suddenly stopped, or the dosage is reduced too quickly. Symptoms may include nausea, headache, dizziness, insomnia, or fatigue. Patients should taper off Sinequan gradually under medical supervision.

Frequently Asked Questions (FAQ)

What should I do if I experience severe side effects from Sinequan?

If you experience severe side effects from Sinequan, such as seizures, trouble breathing, or an irregular heartbeat, seek medical attention immediately.

Can Sinequan be taken during pregnancy or while breastfeeding?

Sinequan should not be taken during pregnancy or while breastfeeding, as it may harm the fetus or nursing baby.

How long does it take for Sinequan to start working?

Sinequan may take several weeks to start working. It is important to continue taking the medication as prescribed, even if you do not see an immediate improvement in your condition.

What should I do if I miss a dose of Sinequan?

If you miss a dose of Sinequan, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.


Additional information

Generic name:

Doxepin, Doxepin Hydrochloride




10mg, 25mg, 50mg, 75mg, 100mg

Quantities Available:



Additional Information Book

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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Sinequan (Doxepin Hydrochloride). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Sinequan (Doxepin Hydrochloride).