Table of contents:
Indications
Prolopa is a combination medication used to treat the symptoms of Parkinson's disease. It is a combination medication that contains two active ingredients - levodopa and benserazide.
Levodopa is a precursor to the neurotransmitter dopamine, a chemical in the brain that is responsible for controlling movement. When taken orally, levodopa crosses the blood-brain barrier and is converted into dopamine in the brain, which helps to alleviate the symptoms of Parkinson's disease. However, much of the levodopa in the body is converted into dopamine in peripheral tissues before it can cross the blood-brain barrier, which can cause side effects.
Benserazide, on the other hand, is an inhibitor of the enzyme that converts levodopa into dopamine in peripheral tissues, which helps to increase the amount of levodopa that reaches the brain and reduces the risk of side effects.
Together, levodopa and benserazide work to increase dopamine levels in the brain, which helps to alleviate the symptoms of Parkinson's disease such as tremors, muscle stiffness, and slow movements.
Use and Dosage
Prolopa is taken orally in the form of capsules, with food as directed by the doctor, usually 4 to 6 times a day. The capsules should be swallowed whole and should not be opened or dissolved in any liquid. Avoid a high-protein diet during treatment, unless directed otherwise by your doctor. Iron supplements or products containing iron (such as multivitamins with minerals) should be taken at separate times, as iron can reduce the amount of levodopa absorbed by the body.
The dosage of Prolopa is based on the patient's medical condition and response to treatment. To reduce the risk of side effects, the doctor may direct the patient to start with a low dose and gradually increase it according to their instructions.
Some patients may experience a "wearing-off" (worsening of symptoms) before the next dose is due, or an "on-off" effect with sudden short periods of stiffness. If these effects occur, the doctor should be contacted for possible dose adjustments.
Prolopa should not be stopped suddenly without consulting the doctor, as doing so may cause withdrawal symptoms such as anxiety, depression, confusion, fever, and muscle stiffness. To prevent withdrawal, the doctor may lower the dose gradually, especially if the medication has been used for a long time or in high doses. If withdrawal symptoms occur, the doctor or pharmacist should be informed immediately.
Side Effects
Common Side Effects of Prolopa (Levodopa/Benserazide):
- Dark sweat or urine
- Diarrhea
- Dizziness, faintness, or lightheadedness when rising from lying or sitting position
- Increase in sexual ability or desire
- Increased sweating
- Nausea
- Nightmares
- Stained saliva or mouth, teeth, and gums
- Vomiting
Serious Side Effects of Prolopa (Levodopa/Benserazide):
- Compulsive behaviour (e.g., gambling, spending)
- False or unusual sense of well-being
- Fast, slow, or irregular heartbeat
- Fainting
- Impaired ability to think
- Mood or mental changes
- Agitation
- Anxiety
- Confusion
- Delusions
- Fearfulness
- Hallucinations (seeing or hearing things that are not there)
- Nervousness
- Restlessness
- Suspiciousness
- Signs of depression (poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
- Taking more medication than ordered
- Unwanted movements or difficulty moving
- Signs of a serious allergic reaction (abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
- Sudden onset of sleep
Forms and Strength
Prolopa (Levodopa/Benserazide) is available in the following forms and strength:
Prolopa: Capsule
- 200/50mg
- 50/12.5mg
Cautions
- Patients with a history of narrow-angle glaucoma should use Prolopa with caution, as it may cause an increase in eye pressure.
- Prolopa may interact with other medications, such as antidepressants and antipsychotics, increasing the risk of side effects such as confusion, hallucinations, and agitation.
- Patients with a history of heart disease, including angina, heart attack, or irregular heartbeats, should be closely monitored while taking Prolopa.
- Prolopa may cause dizziness or lightheadedness, which may be worsened by alcohol or other medications that cause drowsiness.
- Prolopa may cause involuntary movements or dyskinesias, particularly with long-term use or high doses, which may require a reduction in the dose or an alternative treatment.
- Prolopa may cause changes in blood pressure, particularly drops in blood pressure upon standing up, which may require an adjustment in medication or lifestyle changes.
- Patients with a history of liver disease should use Prolopa with caution, as it may affect liver function and require monitoring.
- Prolopa may cause or exacerbate psychiatric symptoms, such as depression, anxiety, or suicidal thoughts, particularly in patients with a history of mood disorders.
- Patients with a history of melanoma or suspicious skin lesions should be closely monitored for skin changes or lesions while taking Prolopa.
- Prolopa may interact with certain foods, particularly high-protein foods, which may reduce its effectiveness.
Frequently Asked Questions (FAQ)
Can Prolopa capsules be opened?
You should swallow the capsules whole, with water. Do not open capsules or dissolve in liquid. Prolopa can cause digestive problems.
How long does it take for Prolopa to start working?
Prolopa typically starts working within 30 to 60 minutes of taking a dose. However, it may take several weeks to see the full effects of the medication.
Can Prolopa be taken with other medications?
Prolopa can interact with other medications, tell your doctor about all the medications you are taking, including over-the-counter medications, supplements, and herbal products. Some medications that may interact with Prolopa include antidepressants, antipsychotics, and blood pressure medications.
Resources
It's important to purchase Prolopa from verified Canadian pharmacy.
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