Indications
Rytary is a brand-name prescription medication used to treat the symptoms of Parkinson's disease, such as tremors, stiffness, and difficulty moving. It is a combination drug made from levodopa and carbidopa, which work together to improve the function of dopamine, a neurotransmitter involved in controlling movement.
Rytary is an extended-release capsule medication that combines immediate-release and extended-release carbidopa-levodopa, which helps to keep medication levels stable and reduce the number of daily dosages required.
Uses and Dosage
Rytary is a medication that comes in the form of capsules to be taken by mouth as directed by your doctor, usually three times a day. Swallow the capsules whole and do not crush or chew them, as doing so can release all the drug at once and increase the risk of side effects. If you have trouble swallowing the capsule, you may open it up and sprinkle the entire contents onto a small amount of applesauce. Do not prepare the mixture in advance for later use; swallow it right away without chewing.
You may take the capsuule with or without food, but it is best to avoid high-protein diets as they can reduce how much of the medication your body can absorb. Additionally, avoid taking this medication with a high-fat, high-calorie meal as it can slow down the time it takes to work by about 2 hours. Take your first dose of the day about 1 to 2 hours before eating, so be sure to ask your doctor or pharmacist how best to take this medication.
Do not take other forms of carbidopa or levodopa without consulting your doctor first. Take the capsules regularly at the same times each day to get the most benefit from it. The dosage is based on your medical condition and response to treatment. Do not change your dose of this or any other medication without checking with your doctor first.
Side Effect
Common Side Effects of Rytary (Carbidopa/Levodopa ER):
- Constipation
- Dizziness
- Dry mouth
- Headache
- Jerky or twisting muscle movements
- Low blood pressure (feeling light-headed)
- Muscle contractions
- Nausea
- Sleep problems, strange dreams
- Vomiting
Serious Side Effects of Rytary (Carbidopa/Levodopa ER):
- Confusion, hallucinations, unusual changes in mood or behavior
- Depression or suicidal thoughts
- Severe nervous system reaction - very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out
- Severe or ongoing vomiting or diarrhea
- Uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement)
- Worsening of tremors (uncontrolled shaking)
Form and Strength
Rytary (Carbidopa/Levodopa ER) is available in the following forms and strength:
Rytary: Extended-Release Capsule
- 23.75/95mg
- 36.25/145mg
- 48.75/195mg
- 61.25/245mg
Caution
- Rytary may cause low blood pressure, especially when standing up quickly. This can lead to dizziness, fainting, or falls, particularly in older adults.
- Rytary may cause hallucinations, confusion, or other changes in mental status, particularly in older adults.
- Rytary may cause dyskinesias (involuntary movements) or worsen pre-existing dyskinesias.
- Rytary may affect your ability to drive or operate machinery, particularly at the beginning of treatment or after a dosage increase.
- Rytary can interact with certain medications and should not be taken with monoamine oxidase inhibitors (MAOIs). Patients should discuss any other medications they are taking with their doctor before starting Rytary.
- Rytary should be used with caution in patients with liver or kidney disease, asthma, heart disease, or a history of ulcers or other gastrointestinal problems.
- Rytary may cause or worsen certain psychiatric effects, such as depression, anxiety, or suicidal ideation.
- Rytary may cause a darkening of urine or sweat, which is not harmful but may be noticeable.
- Rytary should be taken with food to help reduce nausea and other digestive symptoms.
- Rytary may cause or worsen symptoms of glaucoma, especially in patients with a history of this condition.
Frequently Asked Questions (FAQ)
Is Rytary better than other medications for Parkinson's?
Rytary may be beneficial for some patients who experience "off" episodes, or periods of time when their medication wears off before the next dose is due. However, medication choices should be made based on a patient's individual response and needs.
Can Rytary cause dyskinesia (involuntary movements)?
Yes, like other Parkinson's medications, Rytary can cause dyskinesia. It is important to discuss any concerning side effects with a doctor.
Can Rytary be crushed or opened?
Rytary capsules should be swallowed whole and should not be crushed or opened. Doing so can alter the release of the medication and lead to adverse effects.
Can Rytary cause hallucinations?
Yes, hallucinations are a known side effect of Rytary. Patients should report any concerning side effects to their doctor.
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