Indications
Reglan is a prescription medication used to treat gastrointestinal issues such as heartburn, nausea, and vomiting caused by chemotherapy. It contains an active ingredient called metoclopramide. Metoclopramide belongs to a class of drugs called Antiemetic Agents; Prokinetic Agents. It works by increasing muscle contractions in the upper digestive tract, which speeds up the rate at which the stomach empties into the intestines.
Reglan is only intended for short-term use (4 to 12 weeks) and should not be used for longer periods of time without consulting a healthcare provider. It can be indicated to treat a variety of conditions related to the digestive system, and slow stomach emptying (gastroparesis) in patients with diabetes. Metoclopramide can be used to treat conditions caused by diabetes, surgery, radiation therapy and certain medications.
Uses and Dosage
Reglan is available in the form of a scored tablet to be taken by mouth, typically up to four times daily, 30 minutes before meals and at bedtime. Follow the dosage instructions provided by your doctor carefully and not take Reglan more frequently, in larger doses, or for longer than directed, due to the risk of tardive dyskinesia. In some cases, your doctor may instruct you to take a single dose of Reglan before specific times when heartburn occurs, instead of taking it throughout the day, to minimize the risk of side effects.
Reglan can be taken continuously or intermittently for Gastroesophageal Reflux.
- For continuous administration, it is typically recommended to take 10 to 15 mg 30 minutes before each meal and at bedtime, with a maximum of 60 mg per day for 4 to 12 weeks.
- For intermittent administration, single doses of up to 20 mg can be taken prior to situations that may provoke symptoms.
Side Effect
Common Side Effects of Reglan (Metoclopramide):
- Confusion
- Drowsiness
- Headache
- Lack of energy
- Nausea
- Restlessness
- Sleep problems (insomnia)
- Vomiting
Serious Side Effects of Reglan (Metoclopramide):
- Agitation
- Anxiety
- Confusion
- Convulsions (seizure)
- Depression
- Fast or uneven heartbeats
- High fever
- Jittery feeling
- Lightheadedness
- Rapid weight gain
- Shortness of breath
- Sleep problems (insomnia)
- Slow or jerky muscle movements in your face
- Sweating
- Swelling
- Thoughts of suicide or hurting yourself
- Tremors or shaking in your arms or legs
- Trouble staying still
- Very stiff or rigid muscles
Form and Strength
Reglan (Metoclopramide) is available in the following forms and strength:
Metoclopramide: Scored Tablet
- 10 mg
Caution
- Reglan can cause a serious movement disorder called tardive dyskinesia, which may be irreversible.
- Reglan should not be used in patients with Parkinson's disease or other similar movement disorders since it may worsen their symptoms.
- Reglan may increase the risk of gastrointestinal bleeding in patients with a history of bleeding disorders, stomach ulcers, or esophageal varices.
- Reglan may lower the seizure threshold and should be used with caution in patients with a history of seizures.
- Reglan is primarily eliminated by the kidneys and should be used with caution in patients with moderate to severe kidney disease.
- Reglan may interact with certain medications, including opioid pain relievers, sedatives, and antidepressants, and may cause serious side effects.
- Reglan can pass into breast milk and may affect the baby. It is recommended that women should consult with their doctor before taking Reglan while breastfeeding.
- Reglan may cause allergic reactions in some patients, including rash, itching, and swelling.
- Reglan may worsen symptoms of depression, anxiety, or other mental health conditions.
Frequently Asked Questions (FAQ)
Should Reglan be taken with or without food?
Take Metoclopramide on an empty stomach, at least 30 minutes before meals and at bedtime. If you are using the disintegrating tablet, make sure your hands are dry before you handle it.
How long does it take for Reglan/metoclopramide to work?
The onset of action for Reglan/metoclopramide can vary depending on the individual and the condition being treated. Consult with your doctor for specific information.
Can Reglan/metoclopramide be used during pregnancy?
Reglan/metoclopramide may be used during pregnancy if its benefits outweigh the risks. However, consult with their doctor before taking Reglan/metoclopramide.
When is the best time to give Reglan?
Reglan is usually taken 30 minutes before meals and at bedtime, or only with meals that usually cause heartburn.
Resources
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/017854s062lbl.pdf
- https://www.webmd.com/drugs/2/drug-6177/reglan-oral/details
- https://www.mayoclinic.org/drugs-supplements/metoclopramide-oral-route/description/drg-20064784
- https://www.rxlist.com/reglan-drug.htm
- https://www.drugs.com/reglan.html
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