Trulance (Plecanatide)

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Trulance Brand
Dosage Quantity & Price
Plecanatide (Generic alternate to Trulance) Generic

We don't sell this generic-version medication.

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Table of contents:

Trulance is a prescription medication used to treat chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) in adults. It contains the active ingredient plecanatide, which works by stimulating the production of fluids in the intestines and promoting bowel movements. Trulance is known as a guanylate cyclase-C agonist and helps to relieve constipation by binding to receptors in the intestines and stimulating the natural secretions that improve bowel movements.

Trulance is taken orally in the form of a tablet and should be used as directed by a healthcare provider. It increases the action of receptors in the digestive tract that help move stool through more quickly.

Uses and Dosage

Trulance comes in tablet form and is taken orally, with or without food, as directed by a doctor once a day. If you have difficulty swallowing the tablet, you can crush and mix it with a teaspoonful of room-temperature applesauce and swallow the mixture right away. Take Trulance consistently and exactly as prescribed by creating a dosing schedule to avoid missing any doses. Do not change your dosage or stop taking Trulance abruptly without consulting with your doctor to avoid worsening conditions.

Trulance is taken orally in the form of a tablet and as directed by a healthcare provider. The usual recommended dose is 3 milligrams once daily.

Side effect

Common Side Effects of Trulance (Plecanatide):

  • Abdominal distension
  • Abdominal tenderness
  • Diarrhea
  • Gas (flatulence)
  • Increased ALT (alanine transaminase) and AST (aspartate transaminase)
  • Sinusitis
  • Upper respiratory tract infection

Serious Side Effects of Trulance (Plecanatide):

  • Bloating and feeling full in the belly
  • Dehydration
  • Dizziness
  • Flatulence (gas)
  • Nausea
  • Severe abdominal pain
  • Severe diarrhea
  • Sinus infection
  • Stomach pain
  • Urinary tract infection

Form and strength

Trulance (Plecanatide) is available in the following forms and strength:

Trulance: Tablet

  • 3 mg


  • Patients with a history of bowel obstruction, inflammatory bowel disease, or other severe gastrointestinal conditions should talk to their doctor before taking Trulance.
  • Trulance has not been studied in pregnant or breastfeeding women, so use during pregnancy or breastfeeding is not recommended.
  • You should not use Trulance if you are allergic to plecanatide, or if you have a blockage in your intestines.
  • Trulance (plecanatide) caused severe dehydration leading to death in baby animals. To be safe, children younger than 6 years of age cannot take Trulance (plecanatide) because of the risk of this life-threatening dehydration.
  • Trulance (plecanatide) can cause severe diarrhea, which can lead to life-threatening dehydration. Stop using Trulance (plecanatide) and get medical help right away if you develop sudden stomach pain, severe diarrhea, or dizziness.

Frequently Asked Questions (FAQ)

How long does it take for Trulance (plecanatide) to work?

People with long-term constipation saw an improvement in the number of episodes of constipation after about a week of starting Trulance (plecanatide). In general, whether you have long-term constipation or IBS-C, your symptoms should get better over time with daily use.

Can Trulance be taken during pregnancy or breastfeeding?

It is not known whether Trulance is safe to use during pregnancy or breastfeeding. Healthcare providers should be consulted to weigh the risks and benefits of taking Trulance during pregnancy or breastfeeding.

How quickly does Trulance work?

Trulance usually takes 1 to 3 days to work. However, the time it takes for the medication to work may vary depending on the individual and their medical condition.

Can Trulance be taken with other medications?

Tell a healthcare provider about all medications, vitamins, and supplements being taken before starting Trulance. Some medications may interact with Trulance; consult your doctor about which ones you are taking on may be recomended and avoid taking those medications while taking Trulance.


It's important to purchase Trulance from verified Canadian pharmacy.

Additional information

Generic name:






Quantities Available:

30, 90