Allergic Reactions
Do not take Oracea if you are allergic to doxycycline, other tetracycline antibiotics, or any ingredient in the medication.
Seek medical attention right away if you develop signs of a serious allergic reaction, such as swelling of the face or throat, difficulty breathing, hives, or a severe rash.
Pregnancy
Oracea is generally avoided during the second and third trimesters of pregnancy because doxycycline can affect the developing baby’s teeth and bone growth.
If you are pregnant, planning to become pregnant, or think you may be pregnant, talk to your healthcare provider before taking Oracea.
Breastfeeding
Breastfeeding is not recommended during treatment with Oracea and for 5 days after the last dose, according to current prescribing information.
Talk to your healthcare provider about feeding options if you are breastfeeding.
Drug and Supplement Interactions
Oracea can interact with certain medications and supplements.
Tell your healthcare provider about all prescription medicines, over-the-counter products, vitamins, and supplements you take. Products containing calcium, magnesium, aluminum, iron, or bismuth may reduce doxycycline absorption and may need to be taken at a different time.
Sun Sensitivity
Doxycycline can make your skin more sensitive to sunlight and may increase your risk of sunburn.
Limit prolonged sun exposure and avoid tanning beds. Wear protective clothing and use appropriate sun protection when outdoors.
Contact your healthcare provider if you develop a severe sunburn or unusual skin reaction.
Kidney and Liver Problems
Tell your healthcare provider if you have liver or kidney disease before starting Oracea.
Your healthcare provider can determine whether additional monitoring or other precautions are needed.
Autoimmune Conditions
Tetracycline medications, including doxycycline, have rarely been associated with autoimmune reactions, including lupus-like reactions, autoimmune hepatitis, and vasculitis.
Contact your healthcare provider if you develop unexplained joint pain, fever, rash, or unusual tiredness while taking Oracea.
Use in Children
Doxycycline can cause permanent tooth discoloration and may temporarily affect bone growth when used during tooth development.
Oracea is therefore not intended for routine use in young children. Your healthcare provider should decide whether doxycycline is appropriate for a child.
Severe Diarrhea
Doxycycline can sometimes cause Clostridioides difficile-associated diarrhea, which may occur during treatment or after the medication has been stopped.
Contact your healthcare provider if you develop severe, persistent, watery, or bloody diarrhea.
Increased Pressure Around the Brain
Rarely, doxycycline may cause increased pressure around the brain, sometimes called intracranial hypertension or pseudotumor cerebri.
Seek medical attention if you develop a persistent severe headache, blurred vision, double vision, or other sudden vision changes.
Take Oracea as Directed
Take Oracea exactly as prescribed. It is generally taken once daily in the morning on an empty stomach, at least 1 hour before or 2 hours after a meal.
Do not increase your dose on your own. Taking more than the prescribed amount does not improve rosacea faster and may increase side effects.
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