Metaglip (Glipizide/metformin hydrochloride) Shopper Approved

Prescription Prescription Required FormationFormulation: Tablet


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Prescription Prescription Required FormationFormulation: Tablet

Glipizide/metformin hydrochloride

(Generic Alternative)

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Metaglip is a combination of two anti-diabetic medications - glipizide and metformin - that is used along with a diet and exercise program to control high blood sugar levels in patients with type 2 diabetes (non-insulin-dependent diabetes). Proper management of diabetes may also reduce your risk of heart attack or stroke.

Glipizide is a sulfonylurea drug that stimulates the release of your body's natural insulin and reduces the amount of sugar produced by your liver. Metformin is a biguanide drug that reduces the amount of sugar produced by your liver and absorbed by your stomach and intestines. By restoring your body's proper response to insulin, both medications help to control high blood sugar levels, which in turn helps to prevent a range of long-term diabetes-related complications such as kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems.

Use and Dosage

Metaglip is comes as tablet form by mouth, usually once or twice a day with meals or as directed by your doctor. While taking the tablet, drink plenty of fluids unless otherwise directed by your doctor.

The dosage of Metaglip Tablet is determined by your medical condition, response to treatment, and other medications you may be taking. Your doctor may direct you to take a low dose at first, gradually increasing the dose to lower the chance of side effects such as upset stomach and low blood sugar. Your doctor will adjust your dose based on your blood sugar levels to find the best dose for you. Follow your doctor's directions carefully. The usual maximum dose for adults is 2000 milligrams of metformin and 20 milligrams of glipizide each day.

Use Metaglip Tablet regularly to get the most benefit from it. Remember to use it at the same time each day. Inform your doctor if your condition persists or worsens. It may take up to 2 weeks before the full benefit of this drug takes effect.

Side Effects

Common Side Effects of Metaglip (Glipizide/Metformin Hydrochloride):

  • Cold or flu infection
  • Diarrhea
  • Headache
  • Low blood sugar
  • Muscle aches
  • Nausea
  • Stomach upset
  • Vomiting

Serious Side Effects of Metaglip (Glipizide/Metformin Hydrochloride):

  • Blurred vision
  • Cold sweat
  • Confusion
  • Dark urine
  • Difficulty breathing
  • Dizziness
  • Drowsiness
  • Drowsiness
  • Easy bleeding or bruising
  • Fainting
  • Fast heartbeat
  • Fever
  • Flushing
  • Fruity breath odor
  • Headache
  • Hives
  • Hunger
  • Increased thirst
  • Increased urination
  • Persistent nausea
  • Persistent sore throat
  • Rapid breathing
  • Severe stomach pain
  • Shaking
  • Swelling of your face lips tongue or throat
  • Tingling of the hands or feet
  • Yellowing of the eyes or skin (jaundice)

Forms and Strength

Metaglip (Glipizide/Metformin Hydrochloride) is available in the following forms and strength:

Glipizide/metformin hydrochloride: Tablet

  • 2.5/500 mg
  • 5/500 mg


  • Hypoglycemia - may occur when using Metaglip, especially for those with kidney or liver problems, malnourished, exercising or consuming inadequately low-calorie diet, or consuming excessive alcohol.
  • Pancreatitis - inflammation of the pancreas, which is a rare but serious side effect that may occur when using Metaglip. Symptoms may include severe stomach or back pain, nausea, and vomiting.
  • Lactic acidosis - a potential serious condition characterized by too much lactic acid in the body, which may occur due to the use of Metaglip in certain individuals, such as those with kidney or liver problems.
  • Vitamin B12 deficiency - long-term use of Metaglip may result in vitamin B12 deficiency, which can cause anemia, nerve damage, and other problems.
  • Hypersensitivity reactions - allergic reactions to Metaglip could occur, which may include hives, rash, itching, difficulty breathing, and swelling of the face, lips, tongue, or throat.
  • Changes in kidney or liver function - Metaglip may cause changes in kidney or liver function, which may be monitored by your doctor through blood tests.
  • Heart failure - Metaglip may increase the risk of heart failure, particularly in those with a history of heart or kidney disease.
  • Surgery and medical procedures - Metaglip may increase the risks associated with certain surgical or medical procedures, such as X-ray tests requiring contrast agents or surgery under general anesthesia. Your doctor should be informed of the use of this medication before

Frequently Asked Questions (FAQ)

What should I do if I miss a dose of Metaglip?

If you miss a dose of Metaglip, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.

Can I drink alcohol while taking Metaglip?

Avoid alcohol while taking Metaglip, as it may increase the risk of low blood sugar.

Can Metaglip be used in children?

Do not use Metaglip in children, as its safety and effectiveness have not been established in this population.

Can Metaglip cause hypoglycemia (low blood sugar)?

Yes, Metaglip can cause hypoglycemia, particularly in people who skip meals, exercise excessively, or have kidney or liver problems.

Can I stop taking Metaglip if my blood sugar levels improve?

Continue taking Metaglip as prescribed by a healthcare provider, even if your blood sugar levels improve. Stopping the medication without medical guidance may cause high blood sugar levels to return.

How long does Metaglip take to work?

The onset of action of Metaglip may vary depending on individual factors. Follow a healthcare provider's dosing instructions and monitor blood sugar levels regularly.


Additional information

Generic name:

Glipizide/metformin hydrochloride




2.5/500mg, 5/500mg

Quantities Available:

90, 100


Additional Information Book

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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Metaglip (Glipizide/metformin hydrochloride). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Metaglip (Glipizide/metformin hydrochloride).