Indications
Diamicron MR (modified release) is a medication containing the active ingredient gliclazide. It belongs to a class of medications called oral hypoglycemics and is used to control blood glucose (sugar) levels in patients with Type II diabetes mellitus. Gliclazide works by stimulating insulin secretion from the beta cells of the islets of Langerhans, which helps to lower blood glucose levels.
Use and Dosage
Diamicron (gliclazide) is available in Modified Release (MR) Tablets to be taken orally by mouth. The MR formulation is designed to release the medication slowly over a long time, allowing for once-daily dosing. Take the tablets whole with a glass of water, and not to chew or crush them unless specifically instructed to do so by a healthcare provider.
The recommended initial dose for Diamicron MR is 30 mg taken once daily at breakfast time. Your doctor may adjust the dosage every 2 weeks based on your blood glucose levels, gradually increasing it to a maximum of 120 mg daily. Take Diamicron with a glass of water and do not chew or crush the tablets.
Side Effects
Common Side Effects of Diamicron MR (Gliclazide MR):
- Abdominal pain
- Back, muscle, or joint pain
- Constipation
- Diarrhea
- Dizziness
- Headache
- Nausea
- Vomiting
Serious Side Effects of Diamicron MR (Gliclazide MR):
- Abdominal cramps
- Bleeding gums
- Changes in sleep
- Dark urine
- Decreased interest in activities
- Diarrhea
- Difficulty breathing
- Fever or chills
- Loss of appetite
- Nausea
- Poor concentration
- Seizures
- Severe diarrhea
- Shortness of breath
- Skin rash or hives
- Swelling of the face and throat
- Thoughts of suicide
- Unconsciousness
- Unusual nosebleeds
- Vomiting
- Weight loss
- Yellowing of the skin or whites of the eyes
Forms and Strength
Diamicron MR (Gliclazide MR) is available in the following forms and strength:
Diamicron MR: Modified Release Tablets
- 30 mg
Gliclazide MR: Tablets
- 30 mg
Cautions
- Risk of hypoglycemia (low blood sugar levels), especially in the elderly or those with renal or hepatic impairment.
- Caution in patients with a history of sulfonamide allergy or other hypersensitivity reactions.
- Increased risk of cardiovascular events in patients with high-risk factors.
- Caution in patients with impaired kidney or liver function.
- Risk of weight gain and fluid retention.
- Risk of drug interactions with other medications, especially those that affect blood glucose levels.
- Caution in patients with glucose-6-phosphate dehydrogenase deficiency.
- Risk of adverse effects on platelets and blood clotting.
- Caution in pregnant and breastfeeding women.
- Caution in patients with glucose-6-phosphate dehydrogenase deficiency.
- Risk of hemolytic anemia in patients with glucose-6-phosphate dehydrogenase deficiency.
- Risk of liver dysfunction and liver failure.
- Risk of macular edema (swelling of the retina) in patients with diabetes who also have chronic kidney disease.
- Risk of seizure in patients with a history of epilepsy or who are at risk for seizures.
- Caution in patients who are undergoing surgery or who have had recent surgery.
Frequently Asked Questions (FAQ)
Can I drink alcohol while taking Diamicron MR?
Avoid alcohol while taking Diamicron MR, as alcohol can increase the risk of hypoglycemia (low blood sugar levels).
Is Diamicron MR safe to take during pregnancy or while breastfeeding?
Do not take Diamicron MR during pregnancy or while breastfeeding, as its safety in these situations has not been established. It is important to discuss alternative options with a healthcare provider.
Can Diamicron MR be used alone or in combination with other diabetes medications?
Diamicron MR can be used alone or in combination with other diabetes medications, such as metformin. However, consult with a healthcare provider to determine the best treatment plan for an individual's specific needs.
How should Diamicron MR be stored?
Diamicron MR should be stored at room temperature, away from moisture and heat. It should also be kept out of the reach of children and pets.
REVIEWS