Lodosyn (Carbidopa)

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Carbidopa (Generic alternate to Lodosyn) Generic
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Lodosyn is a prescription medication used in combination with levodopa to treat symptoms of Parkinson's disease, such as shakiness, stiffness, or tremors. It contains the active ingredient carbidopa. When taken alone, Carbidopa does not influence these symptoms. Parkinson's disease is believed to be caused by a deficiency of the naturally occurring substance dopamine in the brain.

Carbidopa works by preventing the breakdown of levodopa in the bloodstream before it can reach the brain, allowing more of it to reach the brain and be converted into dopamine. This can help to improve Parkinson's symptoms. Carbidopa can also reduce the occurrence of some of levodopa's side effects, such as nausea and vomiting.

Use and Dosage

Carbidopa comes as a tablet medication that is taken orally with or without food, as directed by your doctor. Your doctor may direct you to take the tablet at the same time as one, some, or all your levodopa/carbidopa doses, carefully follow their instructions. Your dosage will be based on your medical condition and how you respond to the treatment.

The recommended dosage of carbidopa tablet may vary depending on your medical condition and how you respond to the treatment. According to Medscape, the initial dosage of carbidopa for levodopa-naive patients is 25 mg three or four times a day. The dosage may be increased or decreased by 1/2 or 1 tablet a day in accordance with the therapeutic and adverse responses observed. Dosage adjustments should be made by physicians familiar with the patient. However, consult with your doctor before making any changes to your medication regimen.

To get the most benefit from Carbidopa, it should be taken regularly at the same time(s) each day. Some patients may experience a "wearing-off" effect, where their symptoms worsen before the next dose is due, or an "on-off" effect, where sudden short periods of stiffness occur. If these effects occur, contact your doctor for possible dose adjustments that may help to lessen this effect.

Do not stop taking Carbidopa and the levodopa-containing product without consulting your doctor, as some conditions may become worse when these drugs are quickly reduced or suddenly stopped. If your doctor decides to stop your medication, they will likely gradually reduce your dosage over time to prevent any negative effects.

Side Effects

Common Side Effects of Lodosyn (Carbidopa):

  • Involuntary movements (dyskinesia or dystonia)
  • Nausea
  • Dizziness
  • Drowsiness
  • Dry mouth
  • Fatigue
  • Hand tremor
  • Headache

Serious Side Effects of Lodosyn (Carbidopa):

  • Agitation
  • Anxiety
  • Blurred vision
  • Confusion
  • Constipation
  • Convulsions
  • Dark-colored saliva, sweat, or urine
  • Darkening of urine
  • Depression with or without suicidal behavior
  • Lightheadedness
  • Loss of appetite
  • Muscle twitches
  • Nausea
  • Psychotic behavior (e.g., delusions, hallucinations, paranoia)
  • Sweat
  • Trouble sleeping (insomnia)
  • Unusual dreams or nightmares
  • Vomiting

Forms and Strength

Lodosyn (Carbidopa) is available in the following forms and strength:

Carbidopa: Tablet

  • 25 mg


  • Caution is advised in patients with hepatic (liver) disease.
  • Elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose.
  • Caution is advised in patients with a history of depression, as this medication can exacerbate depression or other mental health conditions.
  • Lodosyn may cause drowsiness or dizziness, especially during the first few weeks of treatment, so caution should be exercised while driving or operating machinery.
  • Lodosyn should not be discontinued abruptly, as this can cause symptoms such as stiffness, tremors, and confusion.
  • This medication may interact with other medications, such as antidepressants, antipsychotics, and certain antibiotics, inform your doctor of all medications you are taking before starting Lodosyn.
  • Caution is advised in patients with a history of asthma or other respiratory conditions, as Lodosyn may worsen these conditions.
  • This medication may cause changes in blood pressure, so blood pressure should be monitored regularly during treatment.
  • Caution is advised in patients with a history of cardiovascular disease, as Lodosyn may worsen these conditions.
  • Lodosyn may cause hallucinations or other hallucinatory experiences, especially in elderly patients, so caution should be exercised while taking this medication.
  • Long-term use of Lodosyn may lead to dyskinesia, a movement disorder characterized by involuntary muscle movements, such as twitching or twisting.

Frequently Asked Questions (FAQ)

Can Lodosyn cause dyskinesia?

Long-term use of Lodosyn may lead to dyskinesia, a movement disorder characterized by involuntary muscle movements, such as twitching or twisting.

How long does it take for Lodosyn to start working?

The time it takes for Lodosyn to start working can vary, but it typically starts working within 30 minutes to an hour after taking it.

Can Lodosyn cause withdrawal symptoms if stopped suddenly?

Yes, suddenly stopping Lodosyn can cause withdrawal symptoms, such as muscle stiffness, tremors, and confusion. It should be gradually tapered off under the guidance of a healthcare provider.

How often should Lodosyn be taken?

Lodosyn is usually taken three to four times per day, at evenly spaced intervals, with or without food. The dosing schedule will depend on the individual's condition and response to the medication.


It's important to purchase Lodosyn from verified Canadian pharmacy.

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