Prescription Required
Formulation: Extended Release Tablet
(Brand Option)
Select the prescribed dosage
Select the quantity to see the price.
Prescription Required
Formulation: Extended Release Tablet
Select the quantity to see the price.
* This price includes a dispensing fee, medical review fee, and packing fee.
Shipped and delivered directly to your doorstep
Janumet XR is a prescription medication used to help control blood sugar levels in adults with type 2 diabetes.
It contains two active ingredients: sitagliptin and metformin hydrochloride extended-release. These medications work in different ways to lower blood glucose and improve the body’s ability to manage sugar more effectively.
Janumet XR is generally used together with a healthy diet and regular exercise as part of a complete diabetes management plan.
Janumet XR is used to improve glycemic control in adults with type 2 diabetes when treatment with both sitagliptin and metformin is appropriate.
Type 2 diabetes occurs when the body does not use insulin properly or does not produce enough insulin to keep blood sugar within a healthy range. Over time, this can lead to persistently high blood glucose levels.
Janumet XR helps address several of the processes that contribute to high blood sugar, including excessive glucose production by the liver and reduced insulin effectiveness.
Janumet XR combines two different classes of diabetes medications: a DPP-4 inhibitor and a biguanide.
Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor, while metformin is a biguanide. Because they work through different mechanisms, using them together can provide better blood sugar control for some patients than either medication alone.
The combination helps control blood sugar both after meals and between meals.
Sitagliptin works by increasing the activity of naturally occurring hormones called incretins.
Incretin hormones are released by the digestive system after eating. They help regulate blood sugar by encouraging the pancreas to release insulin when blood glucose levels are elevated.
Sitagliptin also helps reduce the release of glucagon, a hormone that signals the liver to produce and release glucose into the bloodstream.
By increasing insulin release when it is needed and decreasing glucagon levels, sitagliptin can help prevent blood sugar from rising too high.
Metformin hydrochloride extended-release lowers blood sugar mainly by reducing the amount of glucose produced by the liver.
It also helps improve insulin sensitivity, meaning the body’s muscle and other tissues can respond more effectively to insulin and take glucose out of the bloodstream.
Unlike medications that directly stimulate the pancreas to release insulin regardless of blood sugar levels, metformin mainly improves the way the body handles and uses glucose.
The “XR” in Janumet XR stands for extended-release.
The metformin portion of the medication is designed to be released gradually over an extended period rather than all at once. This allows the medication to provide a more sustained effect throughout the day.
The extended-release formulation may also make it possible for Janumet XR to be taken less frequently than some immediate-release formulations, depending on the prescribed treatment plan.
The two active ingredients in Janumet XR complement each other by targeting different causes of elevated blood sugar.
Sitagliptin helps the body release more insulin when blood sugar is elevated and reduces glucagon production. Metformin decreases glucose production in the liver and helps the body use insulin more effectively.
Together, these actions help lower fasting blood sugar as well as increases in blood glucose that occur after eating.
When taken as prescribed, Janumet XR can help improve overall blood sugar control in adults with type 2 diabetes.
Better glucose control may help patients reach their individual blood sugar and A1C targets. A1C is a blood test that provides an estimate of average blood glucose levels over the previous two to three months.
The effectiveness of treatment can vary between patients, so healthcare providers may regularly check blood glucose and A1C levels to determine how well the medication is working.
No. Janumet XR is intended to be used alongside appropriate diet and physical activity rather than as a replacement for them.
Healthy eating, regular exercise, weight management when appropriate, blood sugar monitoring, and taking medications as prescribed are all important parts of managing type 2 diabetes.
Your healthcare provider can recommend an individualized treatment plan based on your blood sugar levels, medical history, and other health factors.
Janumet XR does not cure type 2 diabetes. Instead, it helps control blood glucose levels while the medication is being used.
Type 2 diabetes usually requires long-term management. Continue taking Janumet XR exactly as prescribed, even if your blood sugar improves, unless your healthcare provider advises you to change or stop treatment.
Regular medical follow-up is important so your doctor can monitor your blood sugar, kidney function, treatment response, and overall diabetes management.
Janumet XR is an extended-release tablet taken by mouth once daily. It should usually be taken with a meal, preferably in the evening, unless your doctor gives you different instructions.
Taking Janumet XR with food can help reduce stomach-related side effects associated with metformin, such as nausea, diarrhea, or abdominal discomfort. It can also help your body tolerate the medication more comfortably.
Try to take Janumet XR at about the same time every day. A consistent routine can make it easier to remember your dose and helps support steady blood sugar control.
Janumet XR tablets should be swallowed whole with water.
Do not crush, cut, split, or chew the tablets unless your healthcare provider specifically tells you otherwise. Because Janumet XR is an extended-release medication, the tablet is designed to release the medication gradually over time.
Damaging the tablet may interfere with this extended-release system and could cause too much medication to be released at once, which may increase the risk of side effects.
Taking Janumet XR with a meal can help reduce gastrointestinal side effects caused by metformin.
Some patients may experience nausea, diarrhea, gas, stomach discomfort, or loss of appetite when they first begin treatment. These effects may improve as the body adjusts to the medication.
Taking the medication with food and following the dosing instructions provided by your doctor can help improve tolerability.
Janumet XR works best when it is taken consistently as prescribed.
Continue taking the medication every day even if you feel well or do not notice any symptoms of high blood sugar. Type 2 diabetes may not always cause noticeable symptoms, so regular treatment is important for maintaining blood glucose control.
Do not stop taking Janumet XR or change your dose without first speaking with your healthcare provider.
Janumet XR is only one part of managing type 2 diabetes.
Follow the meal plan, exercise program, blood sugar monitoring schedule, and other recommendations provided by your healthcare team. Maintaining healthy lifestyle habits can improve the effectiveness of your medication and help you reach your individual blood sugar goals.
Your doctor may also recommend regular A1C testing to evaluate your average blood glucose levels over the previous few months.
The dose of Janumet XR is individualized for each patient.
Your doctor may consider your current blood sugar levels, previous diabetes treatment, kidney function, other medical conditions, and how well you tolerate metformin and sitagliptin.
If you were already taking sitagliptin, metformin, or both medications separately, your healthcare provider may use your existing doses to determine an appropriate Janumet XR strength.
Some patients may begin treatment with a lower dose of metformin and have the dose gradually increased.
This approach can help reduce gastrointestinal side effects while allowing the body time to adjust to the medication. Your doctor will determine when and whether your dose should be increased based on your blood sugar levels and how well you tolerate treatment.
Never increase the dose on your own, even if your blood sugar remains higher than expected.
Kidney function is an important consideration when taking Janumet XR because both sitagliptin and metformin are affected by how well the kidneys are working.
Your doctor may check your kidney function before you start treatment and periodically while you are taking the medication. Depending on the results, Janumet XR may not be appropriate for some patients or a different treatment may be recommended.
Tell your healthcare provider if you have a history of kidney disease or reduced kidney function.
Drink adequate fluids while taking Janumet XR unless your healthcare provider has instructed you to limit your fluid intake.
Dehydration can place additional stress on the kidneys and may increase the risk of complications associated with metformin. This can be especially important during periods of vomiting, diarrhea, fever, or excessive sweating.
Contact your doctor if you become significantly dehydrated or are unable to eat or drink normally for an extended period.
Before starting Janumet XR, provide your doctor and pharmacist with a complete list of everything you take.
This includes prescription medications, nonprescription drugs, vitamins, minerals, herbal products, and dietary supplements.
Certain medications can affect blood sugar levels, kidney function, or how sitagliptin and metformin work. Providing a complete medication list allows your healthcare provider to check for possible interactions and make appropriate adjustments to your treatment.
Your healthcare provider may recommend checking your blood glucose regularly while taking Janumet XR.
Monitoring can help show how well your medication, diet, and exercise plan are working together. Keep track of your readings if instructed and discuss unusual or consistently high or low results with your healthcare provider.
Your doctor may adjust your treatment over time based on your blood sugar readings, A1C results, kidney function, and overall response to therapy.
If you miss a dose of Janumet XR, take it when you remember unless it is almost time for your next scheduled dose.
If your next dose is approaching, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed tablet.
If you are unsure what to do after missing a dose, ask your doctor or pharmacist for guidance.
Janumet XR (Sitagliptin/Metformin HCI XR) is available in the following forms and strength:
Janumet XR carries a boxed warning for lactic acidosis, a rare but serious condition caused by a buildup of lactic acid in the blood.
The risk is mainly associated with metformin, one of the active ingredients in Janumet XR. Lactic acidosis can be life-threatening and requires immediate medical attention.
Seek medical help right away if you develop symptoms such as unusual weakness, severe tiredness, muscle pain, difficulty breathing, stomach discomfort, dizziness, or feeling unusually cold.
Janumet XR can affect kidney function, and kidney problems may increase the risk of metformin-related complications.
Tell your healthcare provider if you have a history of kidney disease or reduced kidney function. Your doctor may check your kidney function before and during treatment and may adjust your medication if necessary.
Dehydration can also place extra strain on the kidneys, so contact your healthcare provider if you experience prolonged vomiting, diarrhea, or another condition that causes significant fluid loss.
Janumet XR does not usually cause severe low blood sugar when used alone, but the risk can increase when it is taken with other diabetes medications, particularly insulin or sulfonylureas.
Symptoms of low blood sugar may include sweating, shaking, hunger, dizziness, weakness, confusion, or a fast heartbeat.
Follow your healthcare provider’s instructions for checking your blood sugar and know how to respond if your blood glucose becomes too low.
DPP-4 inhibitors such as sitagliptin have been associated with severe and persistent joint pain in some patients.
Contact your healthcare provider if you develop significant joint pain that does not go away. Your doctor can determine whether Janumet XR may be contributing to your symptoms and whether your treatment should be changed.
Serious allergic reactions to Janumet XR can occur, although they are uncommon.
Possible symptoms include rash, hives, itching, swelling of the face, lips, tongue, or throat, and difficulty breathing or swallowing.
Seek immediate medical attention if you experience symptoms of a serious allergic reaction.
Janumet XR may interact with other prescription medications, over-the-counter drugs, and supplements.
Some medications can affect kidney function, blood sugar levels, or the amount of Janumet XR in your body. Certain blood pressure medications, antibiotics, and other drugs may require additional monitoring when used with Janumet XR.
Tell your doctor and pharmacist about everything you take before starting treatment. Do not start or stop another medication without discussing it with your healthcare provider.
Long-term use of metformin may reduce vitamin B12 levels in some patients.
Symptoms of vitamin B12 deficiency can include unusual tiredness, weakness, numbness or tingling in the hands or feet, and difficulty with balance or walking.
Your healthcare provider may periodically check your vitamin B12 levels, especially if you have symptoms or other risk factors for deficiency. Supplements may be recommended if your levels become too low.
Tell your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding before taking Janumet XR.
Blood sugar control is especially important during pregnancy, but your diabetes treatment may need to be adjusted. Your doctor can determine which medication is most appropriate based on your individual needs.
You should also discuss breastfeeding with your healthcare provider, as they can evaluate the potential benefits and risks of continuing Janumet XR while nursing.
Janumet XR may interact with certain medications, which can affect how well it works or increase the risk of side effects. Some medications, including certain antibiotics, blood pressure medicines, and other drugs that affect kidney function or blood sugar levels, may require additional monitoring when used with Janumet XR. Before starting treatment, tell your healthcare provider about all prescription medications, over-the-counter drugs, vitamins, supplements, and herbal products you are taking. This helps your doctor identify possible interactions and determine whether any dose adjustments or additional monitoring are needed.
Janumet XR may begin lowering blood sugar within hours of the first dose. However, it can take several days or weeks before the full effect on blood glucose control becomes noticeable. The amount of time it takes to work can vary depending on your starting blood sugar levels, diet, activity level, other medications, and individual response to treatment. Continue taking Janumet XR exactly as prescribed, even if you do not notice an immediate change. Your healthcare provider may use blood glucose readings and A1C tests to determine how well the medication is working over time.
Yes. Janumet XR should be taken with food, usually once daily with a meal. Taking it with food can help reduce stomach-related side effects associated with metformin, such as nausea, diarrhea, or abdominal discomfort. For best results, take Janumet XR at approximately the same time each day and follow the meal and dosing instructions provided by your healthcare provider.
| Generic name: | Sitagliptin/Metformin HCI XR |
|---|---|
| Formulation: | Extended Release Tablet |
| Strength(s): | 50/500mg, 50/1000mg, 100/1000mg |
| Quantities Available: | 28, 56, 60, 84, 120, 168, 180 |
Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.
Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies.
When ordering Janumet XR (sitagliptin/metformin HCI XR) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is common for prescription medications to ensure adequate management of chronic conditions without frequent refills.
Here’s what you need to know:
Dosage and Quantity: Janumet XR is available in various strengths such as 50/500mg, 50/1000mg, and 100/1000mg, taken once daily. For a 90-day supply, you would order 90 tablets (90 days x 1 tablet per day).
No, we do not sell sitagliptin/metformin HCl XR on our website. However, you can still enjoy low prices on Janumet XR, which contains sitagliptin and metformin HCl as an active ingredient. To purchase Janumet XR, you will need a valid prescription from your healthcare provider. We require this prescription to dispense the medication. You can mail, fax, or upload your prescription through your online account for processing.
Yes, we ship Janumet XR (sitagliptin/metformin HCI XR) to both the United States and Puerto Rico.
Watch how Online Pharmacies Canada is helping customers save money on their medications.
Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Janumet XR (Sitagliptin/Metformin HCI XR). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Janumet XR (Sitagliptin/Metformin HCI XR).
REVIEWS