Hyzaar (Losartan/HCTZ)

Indications

Hyzaar (Losartan/HCTZ) is a combination medication used to treat high blood pressure (hypertension). It is also used to lower the risk of strokes in patients with high blood pressure and an enlarged heart.

It contains two active ingredients: losartan, an angiotensin receptor blocker (ARB), and hydrochlorothiazide (HCTZ), a diuretic (water pill). Losartan works by blocking the action of certain hormones in the body that can raise blood pressure, while HCTZ helps remove excess fluid from the body, which helps reduce blood pressure. It is available in tablets in the following strengths: 50/12.5 mg, and 100/12.5 mg,

Uses and Dosage

Hyzaar is available in tablet form to be taken orally once a day as prescribed by a doctor. It can be taken with or without food. If it causes frequent urination, it is recommended to take it at least 4 hours before bedtime to avoid having to get up during the night. It is important to follow the specific dosing and administration instructions given by your healthcare provider.

For adults with high blood pressure, the usual starting dose of Hyzaar is 50/12.5 (losartan 50 mg/hydrochlorothiazide 12.5 mg) once daily, and the dosage can be increased after three weeks of therapy to a higher dose if needed. The maximum recommended daily dose is 100 mg of losartan and 25 mg of hydrochlorothiazide.

Side Effects

Common Side Effects of Hyzaar (Losartan/HCTZ):

• Abdominal discomfort
• Dizziness
• Lightheadedness
• Tired feeling
• Confusion
• Constipation

Serious Side Effects of Hyzaar (Losartan/HCTZ)

• Eye pain, vision problems
• Irregular heartbeats
• Kidney problems
  • Little or no urination
  • Rapid weight gain
  • Swelling in your hands, feet, or ankles
• Light-headed feeling, like you might pass out
• Signs of an electrolyte imbalance
  • Feeling jittery or unsteady
  • Increased thirst or urination
  • Irregular heartbeats
  • Leg cramps
  • Loss of movement
  • Muscle pain
  • Numbness or tingling
  • Severe weakness
  • Vomiting

Form and Strength

Hyzaar (Losartan/HCTZ) is available in the following forms and strength:

Hyzaar: Tablet

• 50/12.5mg
• 100/12.5mg
• 100/25mg

Losartan/HCTZ: Tablet

• 50/12.5mg
• 100/12.5mg
• 100/25mg

Caution

• Be aware of potential drug interactions and consult with a healthcare professional for personalized information and advice regarding any medication. Keep a list of all products used, including prescription and non-prescription drugs, and to inform your doctor of any changes in your medical history or any other medications you are taking.
• Before using hyzaar, inform your doctor or pharmacist about your medical history. This includes any history of gout, kidney disease, liver disease, lupus, dehydration, elevated levels of potassium in the blood, and skin cancer. Monitor renal function and potassium levels in susceptible patients while using hyzaar.
• Caution should be considered with hyzaar (losartan/hctz) due to its potential for causing dizziness. Avoid activities that require alertness until you are aware of how the medication affects you.
• Combining hyzaar with alcohol or marijuana can result in an increased risk of dizziness, and you should limit your alcohol intake and consult your doctor about your marijuana use. You must adhere to the instructions provided by your healthcare provider and report any adverse effects or concerns related to the medication.
• Hyzaar can cause severe sweating, diarrhea, or vomiting which can lead to dehydration. Patients taking hyzaar should report any prolonged diarrhea or vomiting to their doctor and drink plenty of fluids unless their doctor advises otherwise to prevent dehydration.
• If you are pregnant or planning to become pregnant, you should discuss the risks and benefits of taking hyzaar with your doctor, as the drug may cause fetal/neonatal morbidity and mortality. If pregnancy is detected, hyzaar should be discontinued as soon as possible.

Frequently Asked Questions (FAQ)

When is Hyzaar prescribed?

Hyzaar is primarily prescribed to treat high blood pressure, but it may also be prescribed for other conditions as determined by a doctor.

Is Hyzaar safe during pregnancy?

No, Hyzaar is not safe during pregnancy. It is classified as pregnancy category D, which means it may cause harm to the developing fetus. Pregnant women should consult with a doctor before taking Hyzaar.

Can Hyzaar be taken with other medications?

It depends on the specific medication. Hyzaar may interact with other medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), potassium supplements, and lithium. inform your doctor about all medications and supplements you are taking before starting Hyzaar.

Can Hyzaar cause kidney problems?

Rarely, Hyzaar may cause kidney problems such as acute renal failure, especially in patients with pre-existing kidney disease or in those taking higher doses of the medication.

How should Hyzaar be stored?

Hyzaar should be stored at room temperature, away from moisture and light. Keep it in its original container and out of reach of children.

Resources

• https://www.drugs.com/hyzaar.html
• https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/020387s057lbl.pdf
• https://www.webmd.com/drugs/2/drug-15636/hyzaar-oral/details
• https://www.mayoclinic.org/drugs-supplements/losartan-and-hydrochlorothiazide-oral-route/side-effects/drg-20062877?p=1
• https://www.goodrx.com/hyzaar/what-is