Indications
Aldactazide is a prescription drug used to treat fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or kidney disorders. It is combination medication contains two diuretic agents, spironolactone, and hydrochlorothiazide.
Spironolactone works by blocking the effects of aldosterone, a hormone that causes the body to retain salt and water. Hydrochlorothiazide works by increasing the amount of salt and water expelled by the kidneys.
Uses and Dosage
Aldactazide is typically available as scored tablets that can be taken by mouth with or without food. Your healthcare provider will provide specific instructions on when and how often to take the medication based on your medical condition and response to treatment. Typically, it is taken once or twice daily, but follow the instructions provided by your doctor or pharmacist.
To get the most benefit from Aldactazide, take it regularly at the same time(s) each day. If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your usual dosing schedule. Take the medication at least 4 hours before bedtime to avoid the need to wake up to urinate during the night. Most people with high blood pressure do not feel sick, follow your healthcare provider's instructions closely.
Aldactazide (spironolactone/hydrochlorothiazide) is typically dosed according to your medical condition.
- For swelling due to liver damage (cirrhosis), nephrotic syndrome, or congestive heart failure, the usual dose is 100 mg/100 mg once or twice a day, taken by mouth.
- For high blood pressure, the typical dose is 50 mg/50 mg to 100 mg/100 mg once or twice a day, taken by mouth.
Side Effect
Common Side Effects of Aldactazide (Spironolactone/Hctz):
- Dizziness
- Drowsiness
- Hair loss
- Itching
- Lack of energy
- Leg cramps
- Feeling unsteady
- Headache
- Ill feeling
- Mouth sores
- Vomiting
Serious Side Effects of Aldactazide (Spironolactone/Hctz):
- Breast swelling and tenderness
- Chills
- Confusion
- Easy bruising
- Extreme thirst
- Eye pain
- Increased urination
- Leg discomfort
- Lightheadedness
- Limp feeling
- Loss of coordination
- Muscle weakness
- Purple or red pinpoint spots under your skin
- Severe weakness
- Slow heart rate
- Slurred speech
- Sore throat
- Sudden weakness
- Tingly feeling
- Uneven heart rate
- Unusual bleeding
- Vision problems
- Weak pulse
- Yellowing of your skin or eyes (jaundice)
Form and Strength
Aldactazide (Spironolactone/Hctz) is available in the following forms and strength:
Aldactazide: Scored Tablet
- 25/25mg
Spironolactone/Hctz: Scored Tablet
- 25/25mg
- 50/50mg
Caution
- Aldactazide is contraindicated in patients who are allergic to spironolactone or hydrochlorothiazide, and in patients with severe kidney or liver disease.
- Aldactazide can interact with other medications, including nonsteroidal anti-inflammatory drugs (NSAIDs), angiotensin-converting enzyme (ACE) inhibitors, and potassium supplements. Inform your doctor of all medications you are taking to avoid potential interactions.
- Aldactazide may cause hyperkalemia or high potassium levels in the blood, which can be dangerous. In addition, it may interact with lithium, leading to increased lithium levels in the blood and potentially serious side effects.
- The medication may cause dizziness, particularly when standing up quickly from a sitting or lying position.
- Aldactazide may cause an increase in blood sugar levels, particularly in patients with diabetes.
- Some patients may experience a decrease in sodium levels in the blood while taking Aldactazide, which can be particularly concerning for patients with liver disease or those who are on a low sodium diet.
- Aldactazide should be used with caution in patients with a history of gout, as it may worsen symptoms.
- Patients taking Aldactazide should avoid potassium supplements or potassium-rich foods, as this may further elevate potassium levels in the blood.
Frequently Asked Questions (FAQ)
Can Aldactazide be taken with food?
Yes, Aldactazide can be taken with or without food. However, it is recommended to take it with food to minimize stomach upset.
Is it safe to drive while taking Aldactazide?
It is generally safe to drive while taking Aldactazide. However, if you experience dizziness or lightheadedness as a side effect, avoid driving or operating heavy machinery.
How long does it take for Aldactazide to start working?
The onset of action of Aldactazide varies depending on the individual, the condition being treated, and the severity of the condition. Consult with your doctor for personalized advice on the expected timeline for effectiveness.
Can Aldactazide be taken during pregnancy or while breastfeeding?
Aldactazide is not recommended for use during pregnancy or while breastfeeding. Consult with a healthcare professional before taking any medication during pregnancy or while breastfeeding.
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