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Formulation: Cream
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Prescription Required
Formulation: Cream
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Efudex Cream contains fluorouracil, a prescription medicine applied directly to the skin. It is used to treat certain sun-damaged, precancerous skin growths and some types of superficial skin cancer.
Efudex is commonly used to treat multiple actinic keratoses, also called solar keratoses.
These are rough, scaly, or crusty patches that develop after repeated sun exposure. They often appear on areas such as the face, scalp, ears, forearms, or backs of the hands.
Actinic keratoses are considered precancerous skin changes because some can develop into squamous cell skin cancer over time.
Efudex helps destroy abnormal sun-damaged cells so healthier skin can grow in their place.
Efudex 5% strength may also be used to treat certain superficial basal cell carcinomas, which are cancers that remain close to the surface of the skin.
This treatment is generally considered when conventional treatments are less practical, such as when there are several lesions or the affected area is difficult to treat surgically. The diagnosis should be confirmed before treatment because Efudex has not been proven effective for all types of basal cell carcinoma.
Efudex belongs to a group of medicines called antimetabolites.
Fluorouracil interferes with the way abnormal cells make and use genetic material needed for growth and division. Because precancerous and cancerous skin cells divide more actively than many normal cells, they are especially sensitive to the medication.
As these abnormal cells are damaged and removed, new skin can gradually form.
Efudex often causes a noticeable skin reaction during treatment. The treated area may become:
This reaction usually develops in stages as abnormal cells respond to the medicine. The expected sequence can include redness, blistering, peeling, erosion, and then healing with new skin formation.
Not necessarily. A significant inflammatory reaction is often an expected part of Efudex treatment.
However, there is a difference between an expected treatment reaction and a reaction that is too severe. Contact your healthcare provider if you develop severe pain, extensive open sores, pus, fever, or other symptoms that concern you.
For actinic or solar keratoses, Efudex is generally applied twice daily in an amount sufficient to cover the lesions.
The usual treatment period is about 2 to 4 weeks, although your healthcare provider may adjust the schedule depending on your skin’s response.
Treatment is typically stopped when the expected inflammatory response reaches the erosion stage. Complete healing may take another 1 to 2 months after treatment has stopped.
For superficial basal cell carcinoma, only Efudex 5% is recommended in the prescribing information.
It is generally applied twice daily for at least 3 to 6 weeks. Some cases may require treatment for as long as 10 to 12 weeks. Follow-up is important to make sure the cancer has been adequately treated.
Skin lesions that do not respond as expected may need further evaluation.
Actinic keratoses that fail to respond may need a biopsy to confirm the diagnosis. Follow-up examination or biopsy may also be needed after treatment of superficial basal cell carcinoma to make sure the cancer is gone.
No. Efudex is not a general treatment for all skin cancers.
Its approved skin cancer use is limited to certain superficial basal cell carcinomas, and only the 5% strength is recommended for that purpose. Deeper or other types of skin cancer may need surgery or another treatment.
Efudex should be applied only to the skin areas your healthcare provider has told you to treat.
It is for topical use only. Do not apply it inside the eyes, mouth, or vagina. Use extra care around sensitive areas such as the nose and lips.
Efudex treats abnormal skin cells by interfering with their ability to grow and divide. During treatment, the skin may temporarily look worse before it improves, with redness, crusting, peeling, and soreness often forming part of the expected response.
Use Efudex exactly as prescribed and do not stop, extend, or restart treatment on your own. Your healthcare provider should monitor how your skin responds and determine when treatment is complete.
Efudex Cream contains fluorouracil and is applied directly to abnormal or sun-damaged areas of the skin. Use it exactly as prescribed by your healthcare provider. For actinic keratoses and superficial basal cell carcinoma, Efudex is commonly applied twice daily, but the length of treatment depends on the condition being treated.
Before applying the cream, gently wash the treatment area and pat it dry. Avoid scrubbing or irritating the skin.
Apply only enough Efudex to cover the affected area with a thin, even layer. Do not apply extra cream because using more will not make the medicine work faster and may increase irritation.
Efudex is preferably applied with a nonmetal applicator or a suitable glove. If you use your fingers, wash your hands thoroughly immediately afterward.
Be careful not to spread the medication to healthy skin or other areas of your body.
For actinic keratoses, Efudex is generally applied twice daily in an amount sufficient to cover the affected lesions. Treatment usually lasts about 2 to 4 weeks.
For superficial basal cell carcinoma, only the 5% strength is recommended. It is generally applied twice daily for at least 3 to 6 weeks, although treatment may sometimes continue for as long as 10 to 12 weeks.
Efudex intentionally causes a reaction in abnormal skin cells. The treated area may gradually become:
The usual treatment response progresses from redness to blistering or peeling, then erosion, followed by healing and new skin formation.
The skin may temporarily look worse before it begins to improve.
For actinic keratoses, treatment is generally continued until the expected inflammatory reaction reaches the erosion stage. Your healthcare provider will tell you when to stop.
Do not stop treatment simply because the skin becomes red unless your healthcare provider has instructed you to do so. However, contact them if the reaction becomes unusually painful, severe, or difficult to manage.
The skin does not always return to normal immediately after Efudex is stopped.
For actinic keratoses, complete healing may take 1 to 2 months after treatment ends. During this time, redness, crusting, peeling, or tenderness may gradually improve as new skin forms.
Do not cover Efudex with tight bandages, plastic wraps, or airtight dressings unless your healthcare provider specifically tells you to.
Covering the treated area can increase the intensity of the skin reaction and may increase absorption of the medicine.
Efudex is for external use on the skin only.
Keep it away from your eyes, eyelids, mouth, and other mucous membranes. If Efudex accidentally gets into your eyes or another sensitive area, rinse thoroughly with plenty of water.
The treated skin may become much more sensitive to sunlight during therapy. Sun exposure can make redness, burning, and inflammation worse.
Try to avoid unnecessary direct sunlight and other sources of ultraviolet light while using Efudex. Follow your healthcare provider’s recommendations for protective clothing and sunscreen.
If you forget to apply Efudex, apply it when you remember unless it is almost time for your next scheduled application.
If your next application is due soon, skip the missed one and continue with your normal schedule. Do not apply a thicker layer or extra cream to make up for the missed application.
Contact your healthcare provider if you develop severe pain, excessive swelling, extensive open sores, pus, fever, or signs of infection.
You should also contact them if you are unsure whether the skin reaction you are experiencing is expected or if the treated area does not heal as expected after treatment.
Follow-up is particularly important when Efudex is used for superficial basal cell carcinoma. Your healthcare provider may need to examine the treated area after healing to make sure the cancer has been adequately treated.
Apply Efudex in a thin layer only to the areas your healthcare provider has told you to treat. Wash your hands after application, avoid sensitive areas, and expect redness and inflammation as the medication works.
For actinic keratoses, treatment commonly lasts 2 to 4 weeks, while superficial basal cell carcinoma may require 3 to 6 weeks or longer. Do not change the treatment length on your own; your healthcare provider should determine when treatment is complete.
Efudex Cream (Fluorouracil) is available in the following forms and strength:
Efudex Cream is for external use on the skin only. Avoid applying it in or around the eyes, eyelids, inside the nose, or mouth.
If the cream accidentally gets into one of these areas, rinse thoroughly with plenty of water. Contact your healthcare provider if irritation continues.
Efudex can make treated skin more sensitive to sunlight. Sun exposure may increase redness, burning, and irritation.
Try to avoid unnecessary direct sunlight and tanning beds during treatment. Follow your healthcare provider’s advice about protective clothing and sunscreen.
The treated area may become red, swollen, sore, crusted, peeling, or raw-looking while Efudex is working. The skin may look worse before it begins to heal.
These reactions can continue for several weeks after treatment ends. Contact your healthcare provider if the reaction becomes unusually severe, painful, or difficult to manage.
Do not cover Efudex with tight bandages, plastic wrap, or airtight dressings unless your healthcare provider specifically tells you to.
Covering the skin can make the reaction stronger and may increase how much medication is absorbed.
Before starting Efudex, tell your healthcare provider about all prescription medicines, over-the-counter products, vitamins, supplements, and other skin treatments you use.
This helps your healthcare provider check for possible interactions and avoid products that may worsen skin irritation.
Use Efudex on the scalp or near the hairline only as directed by your healthcare provider. Temporary hair loss or thinning in the treated area may occur in some people.
Hair usually has the chance to grow back after the skin has healed, but tell your healthcare provider if you notice unexpected or persistent hair changes.
Do not apply Efudex to open wounds or severely broken skin unless your healthcare provider specifically directs you to.
Damaged skin may absorb more medication and may become more irritated.
Efudex should not be used during pregnancy because fluorouracil may harm a developing baby.
If you are pregnant, planning to become pregnant, or breastfeeding, speak with your healthcare provider before using Efudex.
Tell your healthcare provider if you have a history of allergies to fluorouracil or any ingredient in Efudex.
Stop using the medication and seek immediate medical attention if you develop signs of a serious allergic reaction, such as hives, swelling of the face, lips, tongue, or throat, or difficulty breathing.
Tell your healthcare provider if you have a weakened immune system or take medicines that suppress immune function.
Skin that becomes very inflamed or broken during treatment may be more vulnerable to infection. Contact your healthcare provider if you develop increasing pain, warmth, swelling, pus, or fever.
Use Efudex only on the skin areas your healthcare provider has told you to treat. Protect the area from sunlight, avoid tight coverings, and do not apply more cream than prescribed.
Contact your healthcare provider if you develop severe skin reactions, signs of infection, persistent pain, or symptoms of an allergic reaction.
No. Efudex Cream is a prescription medication and should be used only under the guidance of a healthcare provider. Your healthcare provider will determine whether Efudex is appropriate for your skin condition and how long you should use it.
The length of treatment depends on the skin condition being treated and how your skin responds. For actinic keratoses, treatment commonly lasts about 2 to 4 weeks. When Efudex 5% Cream is used for superficial basal cell carcinoma, treatment usually lasts at least 3 to 6 weeks and may sometimes continue longer. Healing can continue for several weeks after treatment ends. Follow the treatment schedule provided by your healthcare provider rather than stopping or extending treatment on your own.
No. Efudex is contraindicated during pregnancy because fluorouracil may harm a developing baby. If you are pregnant, think you may be pregnant, or become pregnant while using Efudex, contact your healthcare provider promptly.
Talk to your healthcare provider before using Efudex while breastfeeding. It is not known whether fluorouracil passes into human breast milk. Because some of the medication can be absorbed through the skin and serious effects in a nursing infant are possible, your healthcare provider may recommend stopping breastfeeding or choosing another treatment.
Store Efudex at room temperature, around 25°C (77°F). Short-term temperatures between 15°C and 30°C (59°F to 86°F) are permitted. Keep the medication securely closed and out of the reach of children and pets.
Before using Efudex, tell your healthcare provider about all prescription medicines, over-the-counter products, vitamins, supplements, and other skin treatments you use. Some topical products may increase skin irritation when used on the same area. Your healthcare provider can determine which products are safe to use during Efudex treatment.
| Generic name: | Fluorouracil |
|---|---|
| Formulation: | Cream |
| Strength(s): | 5% |
| Quantities Available: | 20g, 30g, 60g |
Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.
Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies.
When ordering Efudex Cream (fluorouracil) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is common for prescription medications to ensure adequate treatment without frequent refills.
Here’s what you need to know:
Dosage and Quantity: Efudex Cream is available in 5% strength and is typically applied thinly to the affected area once or twice daily as prescribed by your healthcare provider. The quantity you would order for a 90-day supply depends on the area and frequency of application recommended by your healthcare provider.
Yes, we do sell fluorouracil on our website. You can enjoy competitive prices when ordering from us. To purchase fluorouracil, you will need a valid prescription from your healthcare provider. We require this to dispense the medication safely. You can conveniently submit your prescription by mail, fax, or upload it through your online account during the ordering process.
Yes, we ship Efudex Cream (fluorouracil) to both the United States and Puerto Rico.
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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Efudex Cream (Fluorouracil). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Efudex Cream (Fluorouracil).
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