Zofran Oral Solution (Ondansetron) Shopper Approved

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Zofran Oral Solution

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Zofran Oral Solution is a medication used to prevent nausea and vomiting caused by chemotherapy, radiation, or surgery. It is available in liquid form and is usually taken by mouth. It contains the active ingredient ondansetron.

Ondansetron works by blocking the action of serotonin, a natural substance in the body that can cause nausea and vomiting. By blocking the effects of serotonin, Zofran Oral Solution can help reduce nausea and vomiting in people taking it for certain medical conditions, such as chemotherapy-induced nausea and vomiting.

Use and Dosage

Zofran Oral Solution should be taken exactly as prescribed by your doctor. It is usually taken by mouth with or without food. Measure the liquid medicine with the dosing syringe provided, or with a special measuring spoon or cup.

The first dose of ondansetron is usually taken 30 minutes before the start of chemotherapy, 1 to 2 hours before the start of radiation therapy, or 1 hour before surgery. Additional doses are sometimes taken one to three times a day during chemotherapy or radiation therapy and for 1 to 2 days after the end of treatment.

Follow the directions on your prescription label carefully and ask your doctor or pharmacist to explain any part you do not understand. Take ondansetron exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Side Effects

Common Side Effects of Zofran Oral Solution (Ondansetron):

  • Chills
  • Constipation
  • Drowsiness
  • Headache
  • Tiredness
  • Weakness

Serious Side Effects of Zofran Oral Solution (Ondansetron):

  • Agitation
  • Blurred vision or vision loss
  • Chest pain
  • Coma (loss of consciousness)
  • Confusion
  • Difficulty breathing or swallowing
  • Dizziness, light-headedness, or fainting
  • Excessive sweating
  • Fast, slow, or irregular heartbeat
  • Fever
  • Hallucinations (seeing things or hearing voices that do not exist)
  • Hives
  • Hoarseness
  • Itching
  • Loss of coordination
  • Nausea, vomiting, or diarrhea
  • Rash
  • Seizures
  • Shortness of breath
  • Stiff or twitching muscles
  • Swelling of the eyes, face, lips, tongue, throat, hands, feet, ankles, or lower legs

Forms and Strengths

Zofran Oral Solution (Ondansetron) is available in the following forms and strength:

Zofran Oral Solution: Oral solution

  • 4mg/5mL


  • Avoid taking more than the recommended dose, as it can increase the risk of side effects.
  • Inform your doctor if you have a history of heart problems, liver disease, or electrolyte imbalances.
  • Zofran may interact with certain medications, such as apomorphine or carbamazepine, so be sure to inform your doctor of all medications you are taking.
  • Zofran may cause dizziness or drowsiness, so avoid driving or operating heavy machinery until you know how it affects you.
  • If you are pregnant or breastfeeding, talk to your doctor before taking Zofran, as it may not be safe for use during pregnancy or while breastfeeding.
  • Inform your doctor if you have a history of serotonin syndrome, a condition that can occur when too much serotonin builds up in the body.
  • Zofran may cause constipation, so drink plenty of water and eat a high-fiber diet to help prevent its side effects.
  • If you are taking Zofran for chemotherapy-induced nausea and vomiting, your doctor may monitor your heart function as Zofran can cause changes in heart rhythm.
  • Zofran can cause a severe allergic reaction in some people, including difficulty breathing, hives, and swelling of the face, lips, tongue, or throat. Seek emergency medical attention if you experience these symptoms.
  • Zofran may affect your ability to digest and absorb nutrients, especially if taken on a long-term basis. Your doctor may monitor your electrolyte levels and liver function if you take Zofran for a long time.

Frequently Asked Questions (FAQ)

How should I store Zofran Oral Solution?

Zofran Oral Solution should be stored at room temperature, away from light and moisture. Keep the bottle tightly closed when not in use.

Can Zofran Oral Solution be used to prevent nausea and vomiting caused by chemotherapy in children?

Yes, Zofran Oral Solution is FDA-approved to prevent nausea and vomiting caused by chemotherapy in children aged 6 months and older.

How quickly does Zofran Oral Solution work?

Zofran Oral Solution typically starts working within 30 minutes to 1 hour after taking it, and its effects typically last for up to 12 hours.

Can Zofran Oral Solution be used to treat morning sickness in pregnant women?

Zofran Oral Solution is not typically used to treat morning sickness in pregnant women, as there may be other safer treatment options available. Consult with your doctor for the best course of treatment tailored to your needs.


Additional information

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Oral solution



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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Zofran Oral Solution (Ondansetron). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Zofran Oral Solution (Ondansetron).