Skip to main content

Tolak Cream (Fluorouracil) Shopper Approved

Prescription Prescription Required FormationFormulation: Cream

Tolak Cream

(Brand Option)

Select the prescribed dosage

Select the quantity to see the price.

  *  
Prescription Prescription Required FormationFormulation: Cream

Fluorouracil

We don't sell this generic-version medication.

Select the quantity to see the price.

  *  
delivery

* This price includes a dispensing fee, medical review fee, and packing fee.

delivery

Shipped and delivered directly to your doorstep

Tolak Cream contains the active ingredient fluorouracil. It is a prescription medication applied to the skin to treat actinic keratosis.

Actinic Keratosis

Tolak Cream is used to treat actinic keratoses, which are rough, scaly patches of skin caused by long-term sun exposure.

These spots are considered precancerous because some may eventually develop into a type of skin cancer called squamous cell carcinoma.

Actinic keratoses commonly appear on sun-exposed areas such as the:

  • Face
  • Scalp
  • Ears
  • Forearms
  • Hands

Tolak helps remove abnormal skin cells before they have a chance to progress further.

How Tolak Cream Works

Fluorouracil belongs to a group of medications called antimetabolites.

It works by interfering with the way abnormal skin cells make and use DNA.

Actinic keratosis cells divide more rapidly than normal skin cells, so they are more sensitive to the effects of fluorouracil.

What Happens During Treatment

As Tolak begins to destroy abnormal cells, the treated skin may become:

  • Red
  • Inflamed
  • Sore
  • Crusted
  • Peeling

These skin reactions are common during treatment and can be a sign that the medication is affecting the abnormal cells.

Your healthcare provider can tell you what level of skin reaction is expected and when you should contact them.

What Tolak Does Not Treat

Tolak is intended for actinic keratosis and should not be used on other skin conditions unless your healthcare provider specifically recommends it.

It is not a general treatment for every type of rash, mole, or skin cancer.

Follow-Up Is Important

After treatment, your healthcare provider may examine the treated skin to make sure the actinic keratoses have cleared and to check for any suspicious areas that need further evaluation.

Continue protecting your skin from the sun, since additional actinic keratoses can develop over time.

Tolak Cream is applied directly to areas of actinic keratosis on the face, ears, or scalp.

The usual schedule is:

Apply once daily for 4 weeks, or for the length of time your healthcare provider recommends.

Before Applying Tolak

Gently wash the area you are going to treat.

Rinse the skin and pat it completely dry before applying the medication.

How to Apply Tolak

Apply a thin layer of Tolak Cream over the affected area.

Use your fingertips to gently massage the cream evenly into the skin.

Use only enough cream to cover the area being treated.

Wash Your Hands Afterward

Wash your hands thoroughly after applying Tolak, unless your hands are the area being treated.

Avoid transferring the cream to another person or to other areas of your body.

Areas to Avoid

Tolak is for external skin use only.

Do not apply it:

  • In or around the eyes
  • Inside the nose
  • Inside the mouth
  • On other mucous membranes
  • Vaginally

If Tolak accidentally gets into your eyes, rinse them with plenty of water and seek medical advice.

Do Not Cover With an Airtight Dressing

Do not cover the treated skin with a tight or airtight bandage unless your healthcare provider specifically tells you to.

Covering the area can increase absorption of fluorouracil and may increase side effects.

Protect Your Skin From the Sun

Tolak can make treated skin more sensitive to sunlight.

Limit sun exposure during treatment and immediately afterward. Wear protective clothing and follow your healthcare provider’s advice about sun protection.

Treated skin may sunburn more easily.

What to Expect During Treatment

The treated skin commonly becomes:

  • Red
  • Dry or scaly
  • Crusted
  • Itchy
  • Sore or tender
  • Burning or stinging
  • Swollen

These reactions can become more noticeable as treatment continues and may remain for several weeks after treatment ends.

Contact your healthcare provider if the reaction becomes severe or difficult to tolerate.

What to Do If You Miss a Dose

If you miss an application, apply Tolak when you remember unless it is almost time for your next scheduled application.

If your next dose is approaching, skip the missed application and continue with your regular schedule.

Do not apply extra cream to make up for a missed dose.

Complete the Prescribed Treatment

Use Tolak once daily for the full 4-week treatment period as tolerated, unless your healthcare provider tells you to stop earlier.

Do not use more cream, apply it more frequently, or continue treatment longer than prescribed.

Common Side Effects of Tolak Cream (Fluorouracil):

  • Redness
  • Dryness or scaling
  • Crusting
  • Itching
  • Stinging or burning
  • Swelling
  • Skin erosion or loss of the top layer of skin

Serious Side Effects of Tolak Cream (Fluorouracil):

  • Serious skin or allergic reactions
  • Serious eye problems
  • Severe sun sensitivity
  • Serious systemic toxicity in people with DPD deficiency
    • Severe abdominal pain
    • Bloody diarrhea
    • Repeated vomiting
    • Fever
    • Chills

Tolak Cream (Fluorouracil) is available in the following forms and strength:

Tolak Cream: Cream

  • 4%

Pregnancy

Tolak can harm a developing baby and should not be used during pregnancy.

Tell your healthcare provider if you are pregnant, think you may be pregnant, or plan to become pregnant before using Tolak.

DPD Deficiency

Do not use Tolak if you have dihydropyrimidine dehydrogenase (DPD) deficiency.

People with this enzyme deficiency may not break down fluorouracil properly, which can lead to severe or potentially life-threatening toxicity.

Avoid the Eyes and Mucous Membranes

Tolak is for use on the skin only.

Do not apply it:

  • In or around the eyes
  • Inside the nose
  • Inside the mouth
  • On other mucous membranes

If Tolak gets into your eyes, rinse them thoroughly with water and contact your healthcare provider if irritation continues.

Sun Exposure

Tolak can make treated skin much more sensitive to sunlight.

Avoid unnecessary sun exposure, tanning beds, and sun lamps during treatment and shortly afterward.

Wear protective clothing and follow your healthcare provider’s advice about sunscreen.

Severe Skin Reactions

Redness, crusting, burning, and irritation are common during treatment, but severe reactions can sometimes occur.

Contact your healthcare provider if you develop:

  • Severe pain
  • Significant swelling
  • Open sores
  • Extensive blistering

A reaction that spreads beyond the treated area

Allergic Reactions

Stop using Tolak and seek medical attention if you develop signs of a serious allergic reaction, such as hives, severe rash, swelling of the face or throat, or difficulty breathing.

Peanut Oil Allergy

Tolak contains peanut oil.

Tell your healthcare provider if you have a peanut allergy before using the cream.

Do Not Use on Other Skin Conditions

Tolak should only be used on the areas of actinic keratosis your healthcare provider has told you to treat.

Do not use it on:

  • Unexplained skin lesions
  • Open wounds
  • Infected skin
  • Other rashes or skin conditions

unless your healthcare provider specifically recommends it.

Avoid Airtight Coverings

Do not cover treated skin with an airtight or occlusive dressing unless your healthcare provider tells you to.

Covering the area can increase fluorouracil absorption and may increase the risk of side effects.

Breastfeeding

Tell your healthcare provider if you are breastfeeding.

Your healthcare provider will decide whether Tolak is appropriate and which areas of the body should be avoided during treatment.

Keep Away From Children and Pets

Keep Tolak out of the reach of children and pets.

Fluorouracil can be dangerous if swallowed or accidentally exposed to areas where it was not intended to be used.

Is redness and irritation normal while using Tolak?

Yes. Skin reactions are very common during treatment. You may develop redness, dryness, scaling, crusting, itching, burning, swelling, or skin erosion. These reactions may continue for several weeks after treatment ends.

How long does it take for the skin to heal after Tolak?

The treated skin may remain irritated for several weeks after you finish the 4-week treatment course. Healing time varies depending on how strongly your skin reacts and how large an area was treated. Contact your healthcare provider if the reaction becomes severe or does not begin to improve.

Can I use Tolak Cream during pregnancy?

No. Tolak Cream should not be used during pregnancy because fluorouracil can harm a developing baby. Women who can become pregnant should use effective birth control during treatment and for 1 month after the last application.

Can I use Tolak Cream while breastfeeding?

It is not known whether enough fluorouracil from Tolak Cream passes into breast milk to affect a nursing infant. Talk with your healthcare provider before breastfeeding while using Tolak. Together, you can decide whether to use Tolak or breastfeed.

Can I go out in the sun while using Tolak?

Sun exposure should be limited during treatment and immediately afterward. Tolak can make treated skin more sensitive to ultraviolet light, which may increase irritation or sunburn. Wear protective clothing and follow your healthcare provider’s instructions about sun protection.

Can I put Tolak around my eyes?

No. Do not apply Tolak on the eyelids, around the eyes, or directly in the eyes. Also avoid the nose, mouth, vagina, and other mucous membranes. If Tolak accidentally gets into your eyes, rinse them thoroughly with water and seek medical advice.

What should I do if I miss a dose?

If you miss an application, apply Tolak when you remember unless it is almost time for your next scheduled dose. If your next application is approaching, skip the missed dose and continue with your normal schedule. Do not apply extra cream to make up for a missed dose.

Can I cover Tolak Cream with a bandage?

Do not cover the treated area with an airtight or occlusive dressing unless your healthcare provider specifically tells you to. Covering the skin may increase absorption of fluorouracil and raise the risk of side effects.

Can Tolak be used on other parts of the body?

Tolak is specifically approved for actinic keratoses on the face, ears, and scalp. Its safety and effectiveness have not been established for other areas of the body or for other skin conditions.

Does Tolak Cream contain peanut oil?

Yes. Tolak Cream contains peanut oil as an inactive ingredient. Tell your healthcare provider if you have a peanut allergy or have previously had a serious reaction to peanut products.

How should Tolak Cream be stored?

Store Tolak Cream at room temperature, generally between 20°C and 25°C (68°F to 77°F). Do not freeze it. Keep the tube tightly closed and out of the reach of children and pets. Fluorouracil can be dangerous if swallowed by pets.

REVIEWS

Additional Information Book
Generic name:

Fluorouracil

Formulation:

Cream

Strength(s):

4%

Quantities Available:

40g

Why customers love Online Pharmacies Canada

Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.

Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies.

How to Order

How much Tolak Cream can I order at once from a Canadian pharmacy?

When ordering Tolak Cream (fluorouracil) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is common for prescription medications to ensure adequate management of chronic conditions without frequent refills.

Here’s what you need to know:

Dosage and Quantity: Tolak Cream is commonly prescribed to be applied once or twice daily to the affected area. For a 90-day supply, the quantity you will order would depend on the size of the tubes and the specific treatment plan recommended by your healthcare provider.

Do you sell fluorouracil?

No, we do not sell fluorouracil directly, but you can still enjoy low prices on Tolak Cream, which contains fluorouracil as an active ingredient. You will need a valid prescription from your healthcare provider to purchase Tolak Cream. We require this to dispense the medication safely and appropriately. You can mail, fax, or upload your prescription through your online account.

Do you offer shipping of Tolak Cream (fluorouracil) to the United States?

Yes, we ship Tolak Cream (fluorouracil) to both the United States and Puerto Rico.

Discover Our Users' Stories!

Watch how Online Pharmacies Canada is helping customers save money on their medications.

Online Pharmacies Canada Customer Testimonial #4
Online Pharmacies Canada Customer Testimonial #1
Online Pharmacies Canada - Customer Testimonial #2

Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Tolak Cream (Fluorouracil). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Tolak Cream (Fluorouracil).