Kytril (Granisetron Hcl)

Indications

Kytril is a prescription medication used to prevent nausea and vomiting caused by chemotherapy, radiation, or surgery. Kytril contains the active ingredient granisetron hydrochloride and is available in tablets. Granisetron hydrochloride is a serotonin-3 (5-HT3) receptor antagonist. It works by blocking serotonin, a chemical in the body that can trigger nausea and vomiting.

By blocking the signals to the brain that cause nausea and vomiting, Kytril helps to prevent these unpleasant symptoms. Serotonin is released in response to chemotherapy or radiation therapy, which can lead to nausea and vomiting. Kytril works to combat this by blocking the serotonin in the body.

Uses and Dosage

Kytril (Granisetron HCl) is available in tablet form to be taken orally. When taken to prevent nausea and vomiting caused by chemotherapy, patients typically take Kytril one hour before the chemotherapy session starts. Patients should carefully follow the instructions on the prescription label and ask their healthcare provider or pharmacist to explain any parts they do not understand.

For preventing nausea and vomiting caused by radiation, Kytril is usually taken within one hour before treatment. Depending on the prescription strength, a second dose may be taken 12 hours after the initial dose. Take Kytril exactly as directed and do not take more or less than prescribed or take it more frequently than recommended by the doctor.

Side effect

Common Side Effects of Kytril (Granisetron HCl):

• Constipation
• Diarrhea
• Fever
• Flu Symptoms
• Headache
• Indigestion
• Loss Of Appetite
• Sleep Problems (Insomnia)
• Stomach Pain
• Weakness

Serious Side Effects of Kytril (Granisetron HCl):

• Agitation
• Anxiety
• Buzzing in your ears
• Confusion
• Diarrhea
• Difficulty breathing
• Fainting
• Fast heart rate
• Fast or pounding heartbeats
• Fever
• Hallucinations
• Headache with chest pain and severe dizziness
• Hives
• Loss of coordination
• Nausea
• Overactive reflexes
• Severe headache
• Shortness of breath
• Swelling of your face, lips, tongue, or throat
• Vomiting

Form and Strength

Kytril (Granisetron HCl) is available in the following forms and strength:

Granisetron HCl: Tablet

• 1 mg

Caution

• Patients should not take Kytril if they are allergic to granisetron or any of the other ingredients in the medication.
• Kytril can cause an abnormal heart rhythm called QT prolongation, which can be potentially life-threatening. Patients with a history of heart disease or taking other medications that can cause QT prolongation should use Kytril with caution.
• Patients with liver impairment should use Kytril with caution, as the tablet is metabolized in the liver and may cause an increased risk of side effects.
• Kytril should only be used during pregnancy or breastfeeding if the benefits outweigh the potential risks, as the safety of the medication in pregnant or breastfeeding women has not been established.
• The safety and effectiveness of Kytril in children have not been established, so it should be used with caution in this population.
• Kytril should not be taken with other medications that may also cause QT prolongation or interact with the enzyme system in the liver responsible for metabolizing Kytril, as these interactions may increase the risk of side effects.
• Kytril has been reported to cause depression, anxiety, and other mental health issues in some patients. Patients with a history of mental health conditions should use Kytril with caution and should discuss any concerns with their doctor.
• Kytril may cause dizziness or drowsiness in some patients, which may impair their ability to operate machinery or engage in other activities that require alertness. Patients should avoid driving or operating machinery until they know how Kytril affects them.
• Kytril may cause dehydration, particularly in patients who experience vomiting or diarrhea. Patients should be advised to stay hydrated and seek medical attention if they experience severe vomiting or diarrhea.

Frequently Asked Questions (FAQ)

How long does Kytril stay in the system?

The half-life of Kytril is approximately 3 to 16 hours, which means that it may take up to several days to be completely eliminated from the body.

Can Kytril be used for motion sickness?

Kytril is not approved for the treatment of motion sickness, but it may be used off-label for this purpose under the guidance of a healthcare provider.

Is Kytril addictive?

No, Kytril is not addictive and does not produce a feeling of euphoria or a "high" like some other medications.

Can Kytril be taken with food?

Yes, Kytril may be taken with or without food. Patients should follow their doctor's instructions for proper dosage and administration.

Resources

• https://www.gene.com/download/pdf/kytril_tablets_prescribing.pdf
• https://www.news-medical.net/drugs/Kytril-Tablets.aspx
• https://www.webmd.com/drugs/2/drug-11295/kytril-oral/details
• https://www.rxlist.com/kytril-drug.htm
• https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020239s023lbl.pdf
• https://www.drugs.com/kytril.html
• https://www.ema.europa.eu/en/medicines/human/referrals/kytril