Indications
Emend (active ingredient: aprepitant) is a prescription medication indicated for the following:
- Chemotherapy-Induced Nausea and Vomiting (CINV): Emend is used for the prevention of acute and delayed nausea and vomiting associated with highly emetogenic cancer chemotherapy (HEC) and moderately emetogenic cancer chemotherapy (MEC) in adults and pediatric patients aged 12 years and older.
- Postoperative Nausea and Vomiting (PONV): It is also indicated for the prevention of postoperative nausea and vomiting (PONV) in adults.
Emend belongs to a class of drugs known as neurokinin-1 (NK1) receptor antagonists, which work by blocking the action of substance P, a neurotransmitter involved in the vomiting reflex, thereby preventing nausea and vomiting.
Uses and Dosage
Take Emend (Aprepitant) capsules by mouth with or without food, as instructed by your doctor. Swallow the capsules whole. Take the first dose as directed by your doctor, usually 1 hour before the start of chemotherapy. For the next 2 days, take a dose once a day 1 hour before the start of chemotherapy if you are receiving it that day. If you are not receiving chemotherapy, take the dose once daily in the morning.
The dosage of medication may vary depending on the individual's medical condition, age, and response to treatment. In children, the dosage may also be based on their weight. Your doctor will determine the best dosage for you or your child depending on these factors.
- For adults and children aged 12 and older, the typical starting dose of Emend is 125 mg by mouth given 1 hour before chemotherapy on day 1, followed by 80 mg on day 2 and day 3.
- For children aged 6 months to 11 years old, the dose is based on the child's weight. The typical starting dose is 3 mg/kg by mouth given 1 hour before chemotherapy on day 1, followed by 2 mg/kg on day 2 and day 3.
Side Effect
Common Side Effects of Aprepitant:
- Dizziness
- Headache
- Heartburn
- Hiccups
- Insomnia or trouble sleeping
- Loss of appetite
- Nausea
- Tiredness
Serious Side Effects of Aprepitant:
- Body aches
- Chills
- Fainting
- Fever
- Heavy sweating
- Increased thirst
- Severe abdominal pain
- Unable to urinate
Form and Strength
Emend (Aprepitant) is available in the following forms and strength:
Emend: Capsule
- 80 mg
- 125 mg
Caution
- Before starting to use Emend, disclose your medical history to your physician, including any history of liver or kidney disease. Talk about all other drugs, supplements, and herbal products you are taking due to drug interactions.
- Before taking an aprepitant, let your doctor or pharmacist know if you are allergic to it, fosaprepitant, or any other ingredients. This medication may contain inactive ingredients that can cause allergic reactions or other issues. Speak to your pharmacist for more information.
- During pregnancy, Emend (Aprepitant) should only be used when clearly needed. Discuss the risks and benefits of using the medication with your doctor before taking it. It is unknown if this drug can harm an unborn baby, so be sure to inform your doctor if you are pregnant or plan to become pregnant.
- To reduce the risk of Aprepitant-related adverse effects, limit or stop drinking alcohol and practice caution when performing activities that require alertness.
Frequently Asked Questions (FAQ)
How should Emend be taken?
Emend should be taken as a single dose of 125 mg, 1-2 hours before chemotherapy.
What other medications should not be taken with Emend?
You should not take Emend with certain medications, such as St. John’s Wort, or other medications that can increase the risk of seizures.
Who should not use EMEND?
You should not use EMEND if you are allergic to aprepitant or any of the ingredients in EMEND. You should also not use EMEND if you have severe liver disease.
Is EMEND safe to use?
EMEND is considered safe to use when taken as directed. However, it may cause some side effects, including headache, tiredness, constipation, feeling weak, nausea, liver problems, seizures, and an allergic reaction. If you experience any of these side effects, contact your healthcare provider immediately.
How long does EMEND take to work?
EMEND usually starts to work within 30 minutes of administration, and its effects can last up to 5 days.
Can I take other medications while taking EMEND?
You should always tell your healthcare provider about all the medications you are taking, including prescription and over-the-counter medications, vitamins, and herbal supplements. Certain medications may interact with EMEND and cause serious side effects, so it is important to discuss any potential drug interactions with your healthcare provider.
Is there a generic version of EMEND available?
There is currently no generic version of EMEND available.
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