Indications
Lupron Depot is a medication that contains leuprolide acetate and is used to treat certain disorders such as endometriosis and uterine fibroids. It contains leuprolide acetate and is typically administered by injection into a muscle by a healthcare provider. It works by suppressing the hormones that cause endometrial tissue to grow. It blocks the body from creating certain hormones, such as estrogen or testosterone, which helps stop certain cells from growing.
Lupron Depot is also given to lower the estrogen made by ovaries and is commonly used to treat endometriosis. Additionally, Lupron Depot-Ped works by stopping the body from producing sex hormones and is used to stop or reverse the signs of early-onset puberty in children.
Use and Dosage
Lupron Depot Kit is administered through injection and is available in different dosages and formulations. The Lupron Depot kit usually includes a prefilled dual-chamber syringe, a plunger, alcohol swabs, and prescribing information.
To properly administer Lupron Depot Kit, first learn all preparation and usage instructions from your healthcare professional and the product package. Before injecting each dose, wash your hands and properly mix the medication. Clean the injection site with rubbing alcohol and change the injection site each time to lessen injury under the skin. Inject each dose within 2 hours of mixing. If more than 2 hours have passed since mixing, throw out the product and prepare another syringe/dose. The length of treatment depends on your medical condition, response to treatment, and lab tests.
To ensure maximum benefits from the treatment, use Lupron Depot Kit regularly and mark your calendar to keep track of when to receive the next dose. During the first few weeks of treatment, your hormone levels may go up before they go down, and your symptoms may initially get worse. However, it may take at least 3 months for your symptoms to improve. If your condition does not improve or worsens, inform your doctor. Additionally, make sure to store and discard medical supplies safely.
Side Effects
Common Side Effects of Lupron Depot Kit (Leuprolide Acetate):
- Breast changes, acne, joint/muscle aches, or trouble sleeping
- Dizziness
- Mild burning/pain/bruising at the injection site
- Headache
- Hot flashes (flushing)
- Increased sweating
- Night sweats
- Reduced sexual interest
- Tiredness
- Upset stomach
- Vaginal discomfort/dryness, swelling of the ankles/feet
Serious Side Effects of Lupron Depot Kit (Leuprolide Acetate):
- Allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue.
- Breathing problems
- Chest pain
- Depression or memory disorders
- Pain at site where injected or implanted
- Pain in your legs or groin
- Seizures
- Severe headache
Forms and Strength
Lupron Depot Kit (Leuprolide Acetate) is available in the following forms and strength:
Lupron Depot Kit: Kit
- 7.5 mg
- 11.25 mg
- 22.5 mg
- 30 mg
Leuprolide Acetate: Kit
- 3.75 mg
- 11.25 mg
- 22.5 mg
Cautions
- Adverse reactions have been identified during post-approval use of leuprolide acetate or Lupron Depot-PED in pediatric patients.
- Lupron Depot should be used with caution in patients with a history of seizure disorders or other CNS problems.
- Lupron Depot may cause an increase in bone resorption, leading to possible osteoporosis and bone loss. Bone density should be monitored in patients on long-term therapy.
- Lupron Depot may cause temporary infertility in both males and females. Fertility should be discussed with patients prior to starting therapy.
- Lupron Depot may cause a decrease in glucose tolerance and insulin sensitivity. Blood glucose levels should be monitored in diabetic patients or patients with a history of diabetes. Note that this is not a comprehensive list and other cautions may apply. Consult with a healthcare provider for personalized information and guidance on the use of Lupron Depot Kit (Leuprolide Acetate).
- Lupron Depot may cause cardiovascular events such as heart attack or stroke and should be used with caution in patients with a history of cardiovascular disease.
- Lupron Depot may affect liver function and should be used with caution in patients with liver disease.
- Lupron Depot may cause allergic reactions in some patients and should be used with caution in patients with a history of hypersensitivity reactions.
- Lupron Depot may cause mood changes or depression in some patients and should be used with caution in patients with a history of mental health problems.
- Lupron Depot may interact with other medications and inform healthcare providers of all current medications and medical conditions prior to starting treatment. Again, note that this is not a comprehensive list and consulting a healthcare provider is essential.
Frequently Asked Questions (FAQ)
What should I do if I miss a dose of Lupron Depot Kit?
If you miss a scheduled injection of Lupron Depot Kit, contact your healthcare provider as soon as possible to reschedule.
Can Lupron Depot Kit be used in children?
Lupron Depot Kit can be used in pediatric patients for certain conditions but follow your healthcare provider's recommendations and closely monitor for any side effects.
Does Lupron Depot Kit have any drug interactions?
Lupron Depot Kit may interact with other medications, so inform your healthcare provider of all current medications and medical conditions prior to starting treatment.
How long does it take for Lupron Depot Kit to work?
The timeline for when Lupron Depot Kit starts to work can vary depending on the specific condition being treated and can range from a few days to several weeks.
Resources
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/020517s036_019732s041lbl.pdf
- https://www.webmd.com/drugs/2/drug-1591-5137/lupron-depot-intramuscular/leuprolide-monthly-3-75-mg-injection/details
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020263s036lbl.pdf
- https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cbc8f94e-7330-4465-05ad-16d64493a5dd
- https://www.lupron.com/
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