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Nexavar (active ingredient: sorafenib) is a prescription cancer medication used to treat certain types of liver cancer, kidney cancer, and thyroid cancer.
It belongs to a group of medications called kinase inhibitors. These medications interfere with specific proteins that cancer cells use to grow, divide, and form new blood vessels.
Nexavar is used to treat hepatocellular carcinoma (HCC) that cannot be removed with surgery.
HCC is the most common type of primary liver cancer. When the cancer is considered unresectable, it means surgery cannot safely remove the tumor or is not considered an appropriate treatment option.
Nexavar may help slow the growth and spread of liver cancer cells by blocking signals involved in tumor growth and blood vessel formation.
Nexavar is also used to treat advanced renal cell carcinoma (RCC), the most common type of kidney cancer.
Advanced RCC means the cancer has progressed beyond its original location or cannot be adequately treated with surgery alone.
By blocking certain signaling pathways within cancer cells, Nexavar may help slow tumor growth and disease progression.
Nexavar may be used to treat locally recurrent or metastatic differentiated thyroid carcinoma (DTC) that continues to progress and no longer responds adequately to radioactive iodine treatment.
Locally recurrent means the cancer has returned in or near the thyroid area, while metastatic means it has spread to other parts of the body.
Nexavar is generally considered when the thyroid cancer is radioactive iodine-refractory, meaning radioactive iodine is no longer effective at controlling the disease.
Nexavar belongs to a class of medications known as multikinase inhibitors.
Kinases are proteins that help control many cellular processes, including cell growth, division, survival, and blood vessel formation. Some cancers have abnormal kinase activity that allows cancer cells to continue growing and spreading.
Sorafenib blocks several of these kinase proteins. By interfering with these signals, Nexavar can help slow cancer progression.
Nexavar blocks signaling proteins involved in the growth and survival of cancer cells, including pathways associated with RAF kinases.
Blocking these pathways can interfere with signals that tell cancer cells to grow and divide.
As a result, Nexavar may help:
Nexavar does not necessarily eliminate all cancer cells. Instead, its main purpose is often to control or slow the progression of the disease.
Cancerous tumors need a blood supply to receive the oxygen and nutrients required for continued growth.
Nexavar blocks certain proteins involved in angiogenesis, the process by which new blood vessels develop. These include vascular endothelial growth factor receptors (VEGFRs) and other kinase receptors involved in blood vessel formation.
By interfering with these pathways, Nexavar may reduce the tumor’s ability to develop new blood vessels and obtain the nutrients it needs to continue growing.
Nexavar is considered a form of targeted cancer therapy because it acts on specific molecular pathways involved in cancer growth rather than attacking all rapidly dividing cells in the same way as traditional chemotherapy.
However, these proteins are also involved in some normal functions in the body, so Nexavar can still cause significant side effects and requires regular medical monitoring.
Your healthcare provider will monitor your response to Nexavar throughout treatment. Monitoring may include:
Your dose may need to be temporarily reduced or treatment interrupted if significant side effects occur.
Nexavar is an oral cancer medication taken as tablets. It is commonly used to treat certain types of liver cancer, kidney cancer, and differentiated thyroid cancer.
Take Nexavar exactly as prescribed by your healthcare provider. Do not change your dose, skip doses intentionally, or stop treatment without speaking with your cancer care team.
The usual recommended adult dose of Nexavar is 400 mg twice a day.
Since each Nexavar tablet contains 200 mg of sorafenib, a typical dose consists of:
This provides a total daily dose of 800 mg.
The standard starting dose is generally the same for hepatocellular carcinoma, advanced renal cell carcinoma, and radioactive iodine-refractory differentiated thyroid carcinoma.
Nexavar is usually taken twice daily, so the doses are generally taken about 12 hours apart.
Try to take your doses at approximately the same times every day. Following a regular schedule can make it easier to remember your medication and helps maintain consistent exposure to sorafenib.
Nexavar should be taken without food.
Take each dose:
This timing is important because food can affect how much sorafenib your body absorbs.
Take the prescribed number of tablets by mouth with water and follow the instructions provided by your oncology team.
Do not take additional tablets because you feel the medication is not working quickly enough. Nexavar is a long-term cancer treatment, and its effectiveness is evaluated through medical follow-up rather than by immediate changes in symptoms.
There is no single treatment length that applies to everyone.
Nexavar is generally continued for as long as:
Treatment may be changed or discontinued if the cancer progresses or if side effects become unacceptable.
Yes. Your healthcare provider may reduce your dose, temporarily interrupt treatment, or permanently stop Nexavar if you develop significant side effects.
Dose adjustments may be needed for problems such as severe skin reactions, high blood pressure, bleeding, liver problems, or other treatment-related side effects.
Do not make these changes yourself. Your oncology team will decide whether treatment should be interrupted, restarted, or continued at a lower dose.
If you miss a dose of Nexavar, skip the missed dose and take your next dose at your regular scheduled time.
Do not take two doses at the same time and do not take extra tablets to make up for the missed dose.
If you accidentally take more Nexavar than prescribed, contact your healthcare provider or seek medical attention right away.
Taking too much may increase the risk or severity of side effects. The FDA patient information advises contacting your doctor or going to the nearest emergency department if an overdose occurs.
Consistency is important during cancer treatment. Try to take Nexavar at the same times each day and follow the same meal-spacing instructions with every dose.
A medication reminder, alarm, or pill schedule may help you remember your morning and evening doses.
Tell your healthcare provider about all the medicines you use, including prescription medications, over-the-counter products, vitamins, and herbal supplements.
Some medications can interact with sorafenib or increase the risk of side effects. Your healthcare provider may need to monitor you more closely or adjust your treatment.
While you are taking Nexavar, your healthcare team will monitor how well the medication is working and how your body is tolerating it.
Monitoring may include blood tests, blood pressure checks, physical examinations, and imaging tests. These results can help your healthcare provider decide whether your current dose should be continued or adjusted.
Take Nexavar 400 mg twice daily without food, unless your healthcare provider has prescribed a different dose. Take it at least 1 hour before or 2 hours after a meal. If you miss a dose, skip it rather than doubling your next dose. Continue treatment for as long as your healthcare provider recommends, and never reduce, increase, or stop Nexavar without guidance from your cancer care team.
Nexavar (Sorafenib) is available in the following forms and strength:
Nexavar may increase the risk of serious heart problems, including chest pain, reduced blood flow to the heart, heart attack, or heart failure.
Tell your healthcare provider if you have a history of heart disease. Seek urgent medical attention if you develop chest pain, shortness of breath, severe weakness, or other symptoms of a heart problem.
Nexavar can cause new or worsening high blood pressure.
Blood pressure should be checked regularly, especially during the first several weeks of treatment. The FDA prescribing information recommends weekly monitoring during the first 6 weeks and periodic monitoring afterward. Severe or persistent high blood pressure may require treatment interruption or dose adjustment.
Nexavar may increase the risk of bleeding, which can occasionally become serious.
Tell your healthcare provider if you have a bleeding disorder or take blood-thinning medications. Seek medical attention for unusual bruising, persistent bleeding, coughing or vomiting blood, or black or bloody stools.
Nexavar commonly causes skin problems, particularly hand-foot skin reaction, which may cause redness, swelling, tenderness, or pain on the palms and soles.
More severe skin reactions can also occur. Contact your healthcare provider promptly if you develop severe blistering, peeling skin, painful sores, or a widespread rash. Severe reactions may require the dose to be reduced or treatment to be stopped.
Rarely, Nexavar may cause a hole in the wall of the stomach or intestines, known as gastrointestinal perforation.
This is a medical emergency. Seek immediate care if you develop sudden or severe abdominal pain, swelling of the abdomen, fever, or persistent vomiting.
Nexavar can interfere with normal wound healing.
Tell your healthcare provider if you are planning surgery or have recently had surgery. Current FDA labeling advises withholding Nexavar for at least 10 days before elective surgery and generally not restarting it for at least 2 weeks after major surgery and until the wound has adequately healed.
Nexavar may cause QT interval prolongation, which can affect the heart’s electrical rhythm.
The risk may be greater if you already have heart rhythm problems, have low potassium or magnesium levels, or take other medications that affect the QT interval. Your healthcare provider may monitor your heart rhythm and electrolyte levels if you are considered at higher risk.
Nexavar can occasionally cause serious liver injury.
Your healthcare provider may order regular liver function tests during treatment. Contact your healthcare provider if you develop yellowing of the skin or eyes, dark urine, persistent nausea, severe tiredness, or abdominal pain.
Nexavar may harm an unborn baby.
Pregnancy status may be checked before treatment begins, and effective contraception is recommended during treatment and for the appropriate period after the final dose. Talk with your oncology team about contraception and pregnancy planning before starting Nexavar.
Breastfeeding is not recommended during Nexavar treatment because of the potential risk of serious adverse effects in a nursing infant. Discuss feeding options with your healthcare provider.
For patients taking Nexavar for differentiated thyroid cancer, the medication can interfere with the suppression of thyroid-stimulating hormone (TSH).
Your healthcare provider may check your TSH level regularly, often monthly, and adjust your thyroid hormone replacement medication if necessary.
Nexavar can interact with other medications. Some drugs may lower sorafenib levels or increase the risk of side effects.
Tell your healthcare provider about all prescription medications, over-the-counter medicines, vitamins, and herbal supplements you take. Strong CYP3A4-inducing medications should generally be avoided when possible.
Do not take Nexavar if you have had a severe allergic reaction to sorafenib or any ingredient in the medication.
Seek emergency medical attention if you develop swelling of the face or throat, difficulty breathing, or other signs of a severe allergic reaction.
Because Nexavar can cause serious side effects, regular monitoring is an important part of treatment. Your oncology team may check your blood pressure, liver function, electrolytes, skin, heart health, and other laboratory results and may temporarily stop or reduce your dose if problems develop.
No. Nexavar should generally be taken without food. Take each dose at least 1 hour before eating or 2 hours after a meal. Follow the same schedule each day unless your healthcare provider gives you different instructions.
If you miss a dose of Nexavar, skip the missed dose and take your next dose at the regular scheduled time. Do not take two doses at the same time or take extra tablets to make up for the missed dose.
There is no set treatment length for everyone. Nexavar is generally continued for as long as it is helping control the cancer and the side effects remain manageable. Your healthcare provider will monitor your response and decide how long treatment should continue.
Yes. Your healthcare provider may reduce your dose or temporarily stop treatment if you develop significant side effects. Do not change your dose on your own. Dose adjustments should always be directed by your oncology team.
If you accidentally take more Nexavar than prescribed, contact your healthcare provider or go to the nearest emergency department right away. Do not wait for symptoms to develop before seeking medical advice.
Yes. Nexavar can cause new or worsening high blood pressure. Your healthcare provider may check your blood pressure frequently, particularly during the first several weeks of treatment.
Yes. Nexavar may increase the risk of bleeding, and some bleeding events can be serious. Tell your healthcare provider right away if you notice unusual bleeding, blood in your urine or stool, coughing or vomiting blood, or frequent nosebleeds.
Yes. Nexavar can interact with certain medications. Before starting treatment, tell your healthcare provider about all prescription medications, over-the-counter medicines, vitamins, and herbal supplements you use. It is particularly important to mention medications such as warfarin and drugs that may affect heart rhythm or sorafenib levels.
Nexavar may interfere with wound healing, so your healthcare provider may tell you to temporarily stop treatment before planned surgery. Always tell your surgeon and oncology team that you are taking Nexavar before any procedure.
Nexavar can harm an unborn baby. Tell your healthcare provider if you are pregnant, could become pregnant, or are planning a pregnancy. Your healthcare provider can explain the appropriate contraception requirements during and after treatment.
Breastfeeding is generally not recommended during Nexavar treatment because sorafenib may cause serious side effects in a nursing infant. Talk to your healthcare provider about safe feeding options during treatment.
Nexavar is generally used to control or slow the progression of cancer, rather than being described as a cure. How well it works varies from person to person. Your healthcare provider will use medical examinations, blood tests, and imaging studies to determine how your cancer is responding to treatment.
| Generic name: | Sorafenib |
|---|---|
| Formulation: | Tablet |
| Strength(s): | 200mg |
| Quantities Available: | 112 |
Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.
Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies.
When ordering Nexavar (sorafenib) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is common for prescription medications to ensure adequate management of chronic conditions without frequent refills.
Here’s what you need to know:
Dosage and Quantity: Nexavar is commonly prescribed at a dosage of 400 mg (two 200 mg tablets) taken twice daily. For a 90-day supply, this means you would order 360 tablets (90 days x 4 tablets per day).
No, we do not sell sorafenib separately. However, you can still enjoy low prices on Nexavar, which contains sorafenib as an active ingredient. You will need a valid prescription from your healthcare provider to purchase Nexavar. We require this prescription to dispense the medication, and you can submit it by mail, fax, or upload through your online account.
Yes, we ship Nexavar (sorafenib) to both the United States and Puerto Rico.
Watch how Online Pharmacies Canada is helping customers save money on their medications.
Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Nexavar (Sorafenib). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Nexavar (Sorafenib).
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