Artane (Trihexyphenidyl) Shopper Approved

Prescription Prescription Required FormationFormulation: Scored Tablet


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Prescription Prescription Required FormationFormulation: Scored Tablet


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Artane is a prescription drug primarily indicated to treat the symptoms of Parkinson's disease, such as muscle stiffness and tremors. It contains an active ingredient called Trihexyphenidyl. Trihexyphenidyl belongs to a class of medications called anticholinergics, which work by blocking a certain natural substance called acetylcholine in the brain.

Artane may also be used to treat involuntary movements caused by certain psychiatric drugs, such as chlorpromazine or haloperidol. It can also stop severe muscle spasms of the back, neck, and eyes that are sometimes caused by psychiatric drugs. It can help reduce muscle stiffness, sweating, and the production of saliva, and improve the walking ability of people with Parkinson's disease.

Artane can also reduce other side effects such as muscle stiffness or rigidity (known as extrapyramidal signs), but it may not be helpful in treating movement problems caused by tardive dyskinesia and may worsen them.

Uses and Dosage

To use Artane tablets, individuals should take the medication by mouth as directed by their healthcare provider, typically 3 to 4 times per day with meals and at bedtime. Follow the specific dosing instructions provided by the doctor or pharmacist to ensure safe and effective use of the medication. Artane Tablet should be swallowed whole and not crushed or chewed, as it may cause irritation to the mouth and throat. Taking antacids or certain drugs for diarrhea at the same time as Artane may prevent its full absorption, and taking Artane and ketoconazole together can prevent the complete absorption of ketoconazole.

Take this medication at least one hour before antacids that contain magnesium, aluminum, or calcium, and to allow at least one to two hours between doses of trihexyphenidyl and certain drugs for diarrhea, such as kaolin, pectin, or attapulgite. Additionally, individuals should take the tablet at least two hours after ketoconazole.

The recommended dosage of Artane varies depending on the individual's medical condition, age, and response to therapy. The typical starting dose of Artane is 2 milligram (mg) once a day, which is gradually increased as needed by the doctor. The usual dosage range can be from 3 to 15 mg daily in divided doses, and doses should be individualized.

Side Effect

Common Side Effects of Artane (Trihexyphenidyl):

  • Constipation
  • Decreased urination
  • Dizziness
  • Drowsiness
  • Dry mouth
  • Headache
  • Nausea
  • Nervousness
  • Restlessness
  • Vomiting
  • Weakness

Serious Side Effects of Artane (Trihexyphenidyl):

  • Blurred vision
  • Confusion
  • Eye pain
  • Fast or uneven heartbeats
  • High fever
  • Hot and dry skin
  • Lack of sweating even when you feel hot
  • Lightheadedness
  • Memory problems
  • Painful or difficult urination
  • Rapid or jerky repetitive involuntary movement
  • Seeing halos around lights
  • Severe constipation
  • Sweating
  • Tremors
  • Tunnel vision
  • Unusual thoughts or behavior
  • Very stiff (rigid) muscles

Form and Strength

Artane (Trihexyphenidyl) is available in the following forms and strength:

Trihexyphenidyl: Tablet

  • 2 mg
  • 5 mg


  • Individuals who have a history of glaucoma or who are at risk for developing it should use Artane with caution, as it may worsen the condition.
  • Trihexyphenidyl may cause drowsiness or dizziness, which may impair the individual's ability to drive or perform other tasks that require alertness or coordination. Therefore, it is recommended to avoid such tasks until the person knows how the medication affects them.
  • Individuals with a history of heart disease, high blood pressure, or other cardiovascular conditions should use Trihexyphenidyl with caution and under close medical supervision, as it may cause rapid or irregular heartbeat.
  • Trihexyphenidyl may cause a decrease in sweating, which can increase the risk of heat stroke or heat exhaustion, especially in hot weather or during exercise. Therefore, individuals should avoid becoming overheated and should stay well hydrated while taking Artane.
  • Artane may cause confusion, hallucinations, or other mental/mood changes, particularly in older adults. Therefore, individuals who experience these symptoms should contact their healthcare provider immediately.
  • Individuals with liver or kidney disease should use Trihexyphenidyl with caution and under medical supervision, as the medication may be metabolized more slowly in these patients and lead to potentially harmful effects.

Frequently Asked Questions (FAQ)

Can Artane be used during pregnancy or while breastfeeding?

The safety of Artane during pregnancy or while breastfeeding has not been established, and therefore it is not recommended for use in these situations without first consulting with a healthcare provider.

Can Trihexyphenidyl be used in children?

The safety and effectiveness of Trihexyphenidyl in children has not been established, and therefore it is not typically recommended for use in this population.

Can Artane be used in individuals with a history of glaucoma?

Artane should be used with caution in individuals with a history of glaucoma, as it may worsen the condition.

How long does it take for Trihexyphenidyl to start working?

The onset of action of Trihexyphenidyl is typically within 30-60 minutes after taking it orally.

Is it recommended to stop taking Artane suddenly?

Do not stop taking Artane suddenly, as it may cause withdrawal symptoms.


Additional information

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Scored Tablet


2mg, 5mg

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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Artane (Trihexyphenidyl). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Artane (Trihexyphenidyl).