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Orap is a prescription medication primarily used to treat motor and vocal tics associated with Tourette's syndrome in adults and children. It contains the active ingredient pimozide. Pimozide belongs to a class of medications called antipsychotics. It works by blocking the transmission of dopamine and other neurotransmitters in the brain, which helps to reduce the severity and frequency of tics in people with Tourette's syndrome.

Orap may be used alone or with other medications. It should not be used for mild symptoms. It should only be used if symptoms cause severe problems in everyday life and other medicines or treatments have not been effective. It is not known if Orap is safe and effective in children younger than 2 years of age.

Uses and Dosage

Orap (Pimozide) is available in tablet form for oral consumption with or without food, generally taken once a day at bedtime or as prescribed by your physician. The dose is determined by your medical condition, laboratory tests, and response to treatment.

The recommended dosage of Orap (Pimozide) usually starts at 1 to 2 mg per day in divided doses and may be gradually increased every other day based on the patient's medical condition, laboratory tests, and response to treatment. The dose may be adjusted to reduce the risk of side effects such as tremors. The dosage for children is based on body weight and must be prescribed by a healthcare professional.

Follow your doctor's instructions carefully regarding the dosage and do not take the drug more frequently or increase the dose. A gradual withdrawal is recommended when discontinuing the medication. Alternative dosing strategies may be recommended for patients who are at risk of Pimozide-induced heart rhythm problems.

Side Effects

Common Side Effects of Orap (Pimozide):

  • Constipation
  • Drowsiness
  • Dry mouth
  • Feeling restless
  • Problems with speech or vision
  • Tight muscles
  • Trouble sleeping

Serious Side Effects of Orap (Pimozide):

  • Chills
  • Confusion
  • Difficulty breathing
  • Fast or pounding heartbeats
  • Fast or uneven heartbeats
  • Fever
  • Fluttering in your chest
  • High fever
  • Hives
  • Lightheadedness
  • Mouth sores
  • Seizure
  • Shortness of breath
  • Skin sores
  • Sudden dizziness
  • Sweating
  • Swelling of your face, lips, tongue, or throat
  • Tiredness
  • Tremors
  • Uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement)
  • Very stiff (rigid) muscles

Form and Strength

Orap (Pimozide) is available in the following forms and strength:

Orap: Tablet

  • 4 mg

Pimozide: Tablet

  • 2 mg
  • 4 mg


  • Orap should be used with caution in patients with a history of seizures, as it may lower the seizure threshold.
  • Orap may cause drowsiness, dizziness, or other impairments, so patients should avoid driving or operating heavy machinery until they know how the medication affects them.
  • Orap may interact with other medications, so inform the healthcare provider about all medications, including prescription and over-the-counter medications, as well as any herbal supplements or vitamins being taken.
  • Orap may increase the risk of heart rhythm problems, especially in patients with a history of heart disease, have regular heart monitoring while taking the medication.
  • Avoid eating grapefruit or drinking grapefruit juice while using Orap unless your doctor instructs you otherwise. Grapefruit can increase the amount of this medication in your bloodstream. Consult your doctor or pharmacist for more details.
  • Orap may interact with alcohol and should be avoided or used with caution in patients who consume alcohol. As always, consult with a healthcare provider about the specific cautions and risks associated with any medication, including Orap.
  • Orap is an orally active antipsychotic drug product which shares with other antipsychotic drugs, the risks of unpredictable alterations in mood, thinking and behavior.
  • The longer you use pimozide, the more likely you are to develop certain disorders, especially if you are an older adult. Consult with a healthcare provider about the specific cautions, warnings, and risks associated with any medication, including Orap.

Frequently Asked Questions (FAQ)

How long does it take for Orap (Pimozide) to start working?

It may take several weeks for Orap (Pimozide) to take effect. Your doctor will monitor your symptoms and may adjust the dose or switch to a different medication if necessary.

Can Orap (Pimozide) be used to treat other conditions?

Orap (Pimozide) is primarily used to treat Tourette's syndrome and is not approved for other conditions. It is important to talk to your doctor or healthcare provider about the risks and benefits of using Orap (Pimozide) for your specific condition.

Is Orap (Pimozide) addictive?

Orap (Pimozide) is not considered addictive, but sudden discontinuation of the medication can cause withdrawal symptoms. It is important to follow your doctor's instructions for tapering off the medication if it needs to be stopped.

What should I do if I miss a dose of Orap (Pimozide)?

If you miss a dose of Orap (Pimozide), take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses.


Additional information

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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Orap (Pimozide). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Orap (Pimozide).