Mirapex (Pramipexole)

Indications

Mirapex is a prescription medication that is primarily used to treat the symptoms of Parkinson's disease, such as stiffness, tremors, muscle spasms, and poor muscle control. It can also be used to treat moderate to severe primary Restless Legs Syndrome (RLS).

Mirapex belongs to a class of drugs known as dopamine agonists, which stimulate the dopamine receptors in the brain and mimic the effects of dopamine at these receptors. The active ingredient in Mirapex is pramipexole, which works by increasing dopamine levels in certain parts of the brain.

Uses and Dosage

Mirapex tablets are taken orally and can be taken with or without food as directed by your doctor. The tablets are taken once daily, with or without food, and must be swallowed whole and not chewed or crushed. Taking it with food may help reduce nausea. To minimize the risk of side effects like drowsiness and low blood pressure, your doctor may advise starting with a low dose and gradually increasing it. Follow your doctor's instructions carefully.

The recommended starting dose of Mirapex tablets is 0.125 mg taken once daily, 2-3 hours before bedtime. The dose may be increased every 4-7 days, up to a maximum of 0.5 mg/day. Your doctor may advise starting with a low dose and gradually increasing it to minimize the risk of side effects. It is important to follow your doctor's instructions carefully.

Side Effects

Common Side Effects of Mirapex (Pramipexole):

• Confusion
• Constipation
• Dizziness
• Drowsiness
• Dry mouth
• Increased urination
• Memory problems
• Muscle spasms or weakness
• Nausea

Serious Side Effects of Mirapex (Pramipexole):

• Extreme drowsiness
• Falling asleep suddenly, even after feeling alert
• Hallucinations
• Involuntary bending forward of your neck, waist or tilting sideways when you sit, stand or walk
• Lightheadedness
• Muscle tenderness or weakness
• Sleep problems (insomnia)
• Tremors, twitching or uncontrollable muscle movements
• Unexplained muscle pain
• Unusual dreams
• Vision problems
• Weakness

Form and strength

Mirapex (Pramipexole) is available in the following forms and strengths:

Mirapex: Tablet

• 1 mg
• 0.25 mg
• 0.125 mg

Pramipexole: Tablet

• 1.5 mg
• 1 mg
• 0.5 mg
• 0.35 mg
• 0.25 mg
• 0.18 mg
• 0.125 mg
• 0.088 mg

Caution

• If you miss a dose of Pramipexole, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the next dose as scheduled. Do not double up on doses to make up for a missed dose.
• Pramipexole may cause dizziness or drowsiness. Therefore, avoid driving, using machinery, or performing any activity that requires alertness until you can safely do so. Additionally, alcohol or marijuana (cannabis) may increase these effects, so refrain from consuming alcohol and speak to your doctor if you are using marijuana (cannabis).
• Discuss any allergies with your doctor or pharmacist before taking pramipexole, as this product may contain inactive ingredients that can lead to allergic reactions or other issues. Seek additional information from your pharmacist.
• Misuse of Mirapex may lead to falling asleep during daytime activities such as working, talking, eating, or driving. You may unexpectedly doze off even when you feel alert. Please inform your doctor if you experience excessive daytime sleepiness or drowsiness.

Frequently Asked Questions (FAQ)

What drugs should not be taken with Mirapex?

Some products that may interact with this drug include antipsychotics (such as chlorpromazine, haloperidol, and thiothixene), cimetidine, metoclopramide.

How long should I take pramipexole?

Pramipexole was used for a mean of 8 years (range 0.6-12 years).

How long does it take Mirapex to start working?

It takes about two hours to six hours to work.

Can Pramipexole be used during pregnancy or breastfeeding?

Do not use Pramipexole during pregnancy unless absolutely necessary, as it may harm the developing fetus. It is also not recommended to use Pramipexole while breastfeeding.

Are there any long-term effects of taking Pramipexole?

Long-term use of Pramipexole has been associated with an increased risk of developing impulse control disorders, such as compulsive gambling or shopping. It may also increase the risk of hallucinations or delusions in some people.

Resources

• https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e2902ed1-cfeb-4815-adc3-129c577917a1
• https://www.webmd.com/drugs/2/drug-3683/mirapex-oral/details
• https://content.boehringer-ingelheim.com/DAM/12fba98b-0752-4fe6-99e4-af1e0125cce0/mirapex-us-pi.pdf
• https://www.rxlist.com/mirapex-drug.htm
• https://www.drugs.com/mirapex.html
• https://www.goodrx.com/pramipexole/what-is