Trivastal (generically known as piribedil) is a medication used to treat symptoms of Parkinson’s disease and other movement disorders. It is also sometimes used for the treatment of restless leg syndrome. It works by stimulating dopamine receptors in the brain, which can improve movement and reduce tremors.
Trivastal is often used in combination with levodopa, another medication commonly used to treat Parkinson’s disease. Piribedil is available in sustained release coated tablets and is contraindicated in case of fructose intolerance, glucose, and sucrose.
Use and Dosage
Trivastal comes in the form of a sustained-release tablet that is taken orally, usually taken once a day, with food, and at the same time each day to maintain a consistent level of medicine in the bloodstream. Swallow the tablet whole and do not chew, crush, or break the tablet. You should take the medication in the dose and duration as advised by your doctor. If you have difficulty swallowing pills, you should speak with your doctor or pharmacist about possible alternative formulations or options.
The initial dose may vary, depending on the individual’s medical condition, but the usual starting dose of Trivastal Retard 50, a sustained release coated tablet, is one tablet (50mg) daily during the first week, after which the dosage should be gradually increased. However, take Trivastal Sustained Release Tablet only under the guidance of a physician. Trivastal Tablet SR should be taken with food to avoid stomach upset. Take Trivastal LA Tablet SR at the same time each day to maintain a consistent level of medicine in the bloodstream.
Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose, then the missed dose can be skipped. Contact your doctor if you have missed more than one scheduled dose of the medication.
Common Side Effects of Trivastal (Piribedil):
- Feeling of discomfort
Serious Side Effects of Trivastal (Piribedil):
- Agitation and anxiety
- Compulsive behavior
- Increased libido
- Low blood pressure
- Nausea and vomiting
- Severe skin rash and hives
- Sudden sleeping fits
Forms and Strength
Trivastal (Piribedil) is available in the following forms and strength:
Trivastal: Sustained Release Tablet
- 50 mg
- Interactions with warfarin: Piribedil may prolong the International Normalized Ratio (INR) of patients taking warfarin.
- Not recommended for use during pregnancy or breastfeeding: The safety of piribedil during pregnancy or breastfeeding has not been established, and it is generally not recommended for use in these populations.
- Possibility of hallucinations and psychosis: Piribedil may cause hallucinations or psychosis, particularly in elderly patients or those with a history of cognitive impairment.
- Potential adverse effects: Patients taking dopamine agonists like piribedil should be alerted to the possible adverse effects of these medications.
- Potential interactions with other medications: Piribedil may interact with other medications, such as neuroleptics, antidepressants, or other dopamine agonists, leading to adverse effects.
- Risk of impulse control disorders: Dopamine agonists like piribedil have been associated with the development of impulse control disorders, such as compulsive gambling, shopping, or eating, in some patients.
- Risk of orthostatic hypotension: Piribedil can lower blood pressure, and patients taking the medication may experience dizziness or fainting upon standing up. Elderly patients and those with a history of low blood pressure are particularly at risk.
- Safety precautions: Patients with certain medical conditions, such as liver problems, should exercise caution when taking dopamine agonists like piribedil.
- Side effects on the aging brain: Dopamine agonists like piribedil can have side effects on the mesolimbic dopaminergic system, which can affect cognitive and other functions of the aging brain.
- Withdrawal effects: Most of the available data on piribedil is on dopamine agonists, and withdrawal from these medications can lead to impulsive and compulsive behaviors in Parkinson’s disease patients.
Frequently Asked Questions (FAQ)
Can Trivastal (Piribedil) be taken with food?
Trivastal (Piribedil) can be taken with or without food, but certain foods or drinks (such as alcohol) may interact with the medication and alter its effects.
How long does it take for Trivastal (Piribedil) to start working?
The onset of action of Trivastal (Piribedil) may vary depending on individual factors, but some patients may notice improvements in their symptoms within a few hours of taking the medication.
Can Trivastal (Piribedil) make Parkinson’s symptoms worse?
In some rare cases, Trivastal (Piribedil) may worsen Parkinson’s symptoms, particularly if the dosage is too high or if the patient has certain pre-existing medical conditions. If you experience any worsening of symptoms, contact your healthcare provider immediately.
Is Trivastal (Piribedil) addictive?
Trivastal (Piribedil) has not been shown to be addictive, but it can lead to dependence or withdrawal symptoms if it is abruptly stopped after prolonged use.