Cogentin Injection (Benztropine)

Indications

Cogentin is an injectable prescription medication used to treat symptoms of Parkinson's disease or involuntary movements caused by certain psychiatric drugs (antipsychotics).

Cogentin contains benztropine mesylate. Benztropine mesylate belongs to the class of anticholinergic agents and works by blocking the action of acetylcholine, a neurotransmitter, which is responsible for the contraction of muscles and function of various organs. In turn, Cogentin helps to reduce parkinsonian-like symptoms like tremors, muscle stiffness, and slow movements, which are caused by an imbalance of acetylcholine and dopamine in the brain.

Use and Dosage

It is typically administered as an injection and is available in a 1 mg per mL dosage strength. Your doctor will direct you to take Cogentin either by injection into a vein or into a muscle 2 to 4 times a day, or as a single dose at bedtime. If you are self-administering this medication, be sure to follow all preparation and usage instructions provided by your healthcare professional.

Before using Cogentin, visually check the product for any particles or discoloration. If you see either, do not use the liquid. To minimize the risk of side effects, your doctor may start you on a low dose and slowly increase it. The dosage amount will depend on your age, medical condition, and response to treatment.

Use Cogentin regularly at the same time(s) each day to gain maximum benefit. Your doctor may recommend that you take this medication on a regular schedule or only as needed if you are using it for medication-induced side effects. If you are taking it for Parkinson's disease, your doctor may change the dosage of other medications you are taking, such as levodopa.

If you use Cogentin injection for a prolonged period, it may lose its effectiveness. In this case, discuss this with your doctor.

While Cogentin is helpful for many people, it may pose a risk of addiction. Inform your doctor if you have a history of substance use disorder and be sure to take it as prescribed to reduce the likelihood of addiction. Do not increase the dose, take it more frequently or for a longer duration than advised. Discontinue its use in the manner directed by your doctor, as stopping its use abruptly can exacerbate some medical conditions.

It may take 2-3 days before you experience the therapeutic effects of Cogentin. Contact your doctor if your condition persists or deteriorates.

Side Effects

Common Side Effects of Cogentin Injection (Benztropine):

• Constipation
• Depression
• Dizziness
• Double vision
• Drowsiness
• Dry mouth
• Excitability
• Fast heartbeat
• Headache
• Increased sensitivity to light
• Loss of appetite
• Memory problems
• Nausea and vomiting
• Nervousness
• Numbness in your fingers
• Sleeplessness
• Slowed gut movement
• Stomach upset
• Trembling of the hands
• Vision changes

Serious Side Effects of Cogentin Injection (Benztropine):

• Being unable to sweat when feeling hot
• Blurry vision
• Confusion
• Depression
• Diarrhea
• Discomfort while urinating
• Dizziness
• Fainting
• Fever
• Memory problems
• Muscle or stomach cramps
• Nausea
• Numbness in the fingers
• Seeing, hearing, or smelling things that aren’t there (hallucinations)
• Severe confusion or nervousness
• Severe muscle weakness
• Severe nausea and vomiting
• Severe nervousness
• Tiredness

Forms and Strength

Cogentin Injection (Benztropine) is available in the following forms and strength:

Benztropine: Ampules

• 1mg/mL

Cautions

• Allergic Reactions: You should not use Cogentin Injection if you are allergic to any of its ingredients, particularly benztropine.
• Pediatric Use: Cogentin Injection is contraindicated in pediatric patients under certain circumstances, as it may cause paradoxical excitation (a state of agitation or restlessness).
• Glaucoma: Cogentin Injection should be used with caution in patients with glaucoma, as it may increase intraocular pressure and worsen the condition.
• Prostate enlargement: Patients with prostate enlargement should use Cogentin Injection with caution, as it may cause urinary retention and worsen the condition.
• Bowel/Bladder obstruction: Cogentin Injection should be used with caution in patients with bowel or bladder obstruction, as it may worsen the condition.
• Dementia-related Psychosis: Cogentin Injection is not recommended for use in treating dementia-related psychosis, as it may increase the risk of death.
• Cardiovascular disease: Cogentin Injection should be used with caution in patients with cardiovascular disease, as it may cause arrhythmias (irregular heartbeats) and worsen the condition.
• Hepatic impairment: Patients with hepatic impairment should use Cogentin Injection with caution, as the medication may accumulate in the body and worsen the condition.
• Renal impairment: Patients with renal impairment may need to adjust their Cogentin Injection dosage, as the medication may accumulate in the body and worsen the condition.
• Pregnancy and breastfeeding: Cogentin Injection should be used with caution in pregnant or breastfeeding women, as the medication may pass into breast milk or harm the fetus.
• Drug interactions: Cogentin Injection may interact with other medications, such as antihistamines or antidepressants, and cause side effects or worsen existing medical conditions.

Frequently Asked Questions (FAQ)

Is Cogentin Injection (Benztropine) safe for use during pregnancy or while breastfeeding?

It is not recommended that pregnant or breastfeeding women use Cogentin Injection (Benztropine), as the medication may pass into breast milk or harm the fetus.

What should I do if I miss a dose of Cogentin Injection (Benztropine)?

If you miss a dose of Cogentin Injection (Benztropine), take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Resources

• https://www.rxlist.com/cogentin-drug.htm
• https://www.goodrx.com/benztropine/what-is
• https://www.healthline.com/health/drugs/benztropine-injectable-solution
• https://www.empr.com/drug/benztropine-injection/
• https://www.webmd.com/drugs/2/drug-279/cogentin-injection/details
• https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/012015s026lbl.pdf