Zyprexa Zydis (Olanzapine)

Indications

Zyprexa Zydis is an orally disintegrating form of olanzapine, an antipsychotic medication that is used to treat conditions such as schizophrenia and bipolar disorder. It contains an active ingredient called Olanzapine. Olanzapine belongs to the group of medications known as antipsychotic agents. It works by helping to restore the balance of certain natural substances in the brain.

Olanzapine can be used in combination with other medication to treat depression. It can decrease hallucinations and help you to think more clearly and positively about yourself, feel less agitated, and take a more active part in everyday life. Olanzapine tablet is intended for oral administration and is available in various dosages.

Uses and Dosage

Zyprexa Zydis (Olanzapine) is an orally disintegrating tablet that should be taken by mouth, with or without food, as directed by your doctor, usually once a day. The tablets come in a blister or a bottle, so do not remove the tablet from the packaging until ready to take it.

When handling the tablet, make sure your hands are dry. If the tablet comes in a blister, carefully peel back the foil to remove it without damaging the tablet. Place the tablet on your tongue and allow it to dissolve, after which it can be swallowed with or without liquid.

The recommended dosage of Zyprexa Zydis (Olanzapine) will depend on your medical condition and response to treatment. The recommended starting dose for adults with schizophrenia or bipolar disorder is typically 5 to 10 milligrams (mg) once a day, and the maximum daily dosage is 20 mg. However, your doctor may adjust your dosage based on your individual needs and response to treatment.

Side effect

Common Side Effects of Zyprexa Zydis (Olanzapine):

• Constipation
• Dizziness, especially when rising quickly from a lying or sitting position
• Drowsiness
• Dry mouth or eyes
• Fatigue
• Fluid retention
• Increased appetite
• Rash
• Restlessness
• Weakness
• Weight gain

Serious Side Effects of Zyprexa Zydis (Olanzapine):

• Accidental injury
• Constipation
• Dizziness/low blood pressure upon standing
• Drowsiness, dose dependent
• Dry mouth
• Elevated alanine aminotransferase (ALT) level
• Elevated levels of prolactin in the blood
• Extrapyramidal symptoms (EPS), dose dependent (muscle spasms, jerky movements, slow movements)
• High blood sugar
• High cholesterol
• Elevated levels of triglycerides in the blood
• Indigestion
• Insomnia
• Low blood pressure
• Parkinsonism reactions
• Restlessness
• Tremor
• Weakness
• Weight gain, dose dependent

Form and Strength

Zyprexa Zydis (Olanzapine) is available in the following forms and strength:

Zyprexa Zydis: OD Tablet

• 20 mg

Zyprexa Zydis: OD Tablet

• 10 mg
• 15 mg
• 20 mg

Caution

• Olanzapine may cause weight gain, high blood sugar, high cholesterol, and other metabolic changes that can increase the risk of diabetes and heart disease.
• Zyprexa Zydis may cause dizziness or drowsiness and may impair your ability to perform tasks that require alertness and clear thinking, such as driving or operating machinery.
• Zyprexa Zydis should be used with caution in patients with a history of seizures, liver or kidney disease, or cardiovascular disease.
• Zyprexa Zydis may cause a drop in blood pressure upon standing, particularly in adults over the age of 65.
• Zyprexa Zydis should not be used in combination with alcohol or other drugs that can cause sedation or respiratory depression, as this can increase the risk of serious side effects.
• Olanzapine may also increase the risk of suicidal thoughts and behaviors in some patients, particularly in children, adolescents, and young adults.
• Olanzapine may cause a condition called neuroleptic malignant syndrome (NMS), which can be life-threatening. Symptoms may include fever, muscle stiffness, confusion, and rapid or irregular heartbeat.
• Zyprexa Zydis may cause tardive dyskinesia, a movement disorder characterized by repetitive, involuntary muscle movements, particularly in the face and tongue.
• Zyprexa Zydis may increase the risk of stroke or transient ischemic attack (TIA) in elderly patients with dementia-related psychosis.

Frequently Asked Questions (FAQ)

Is Zyprexa Zydis safe for children and teenagers?

Zyprexa Zydis is not approved for use in children younger than 13 years old. It is only approved for use in children aged 13 to 17 years old for the treatment of schizophrenia and bipolar disorder.

How long does it take for Olanzapine to start working?

It may take several weeks to see the full effects of Olanzapine. Your doctor will monitor your progress and adjust your dosage as needed.

Can Zyprexa Zydis be taken with food?

Zyprexa Zydis can be taken with or without food. The medication should be taken as directed by your doctor.

Resources

• https://www.rxlist.com/olanzapine/generic-drug.htm
• https://www.medbroadcast.com/drug/getdrug/zyprexa-zydis
• https://www.drugs.com/mtm/zyprexa-zydis.html
• https://www.webmd.com/drugs/2/drug-19876/zyprexa-zydis-oral/details
• https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d5051fbc-846b-4946-82df-341fb1216341
• https://www.accessdata.fda.gov/drugsatfda_docs/label/2004/20592se1-019_zyprexa_lbl.pdf