Weight Gain and Metabolic Changes
Zyprexa Zydis can cause significant weight gain and changes in blood sugar and cholesterol levels.
Your healthcare provider may monitor your:
- Weight
- Blood sugar
- Cholesterol and triglycerides
Tell your healthcare provider if you develop symptoms of high blood sugar, such as increased thirst, frequent urination, increased hunger, or unusual weakness.
Drowsiness and Trouble Thinking Clearly
Zyprexa Zydis may cause:
- Drowsiness
- Dizziness
- Slower reaction time
- Problems with judgment or concentration
Do not drive, operate machinery, or perform other activities that require alertness until you know how the medication affects you.
Low Blood Pressure and Dizziness
Olanzapine can cause a sudden drop in blood pressure when you stand up.
This is called orthostatic hypotension.
Symptoms may include:
- Dizziness
- Lightheadedness
- Fainting
- A fast or slow heartbeat
Stand up slowly from a sitting or lying position, especially when you first start treatment or after your dose is increased.
Alcohol
Avoid or limit alcohol while taking Zyprexa Zydis.
Alcohol may increase drowsiness, dizziness, and low blood pressure caused by olanzapine.
Tell your healthcare provider about other medications that can make you sleepy, because their effects may be increased when taken with Zyprexa Zydis.
Neuroleptic Malignant Syndrome
Rarely, Zyprexa Zydis can cause a serious and potentially life-threatening condition called neuroleptic malignant syndrome (NMS).
Seek emergency medical attention if you develop symptoms such as:
- High fever
- Severe muscle stiffness
- Confusion
- Heavy sweating
- Changes in blood pressure
- Fast or irregular heartbeat
NMS requires immediate medical treatment.
Tardive Dyskinesia
Zyprexa Zydis may cause tardive dyskinesia, a movement disorder that can sometimes become permanent.
Symptoms may include uncontrolled or repetitive movements of the:
- Face
- Lips
- Tongue
- Jaw
- Arms or legs
Tell your healthcare provider right away if you notice unusual or uncontrolled movements.
Seizures
Zyprexa Zydis should be used carefully in people who have a history of seizures or conditions that may increase the risk of seizures.
Tell your healthcare provider if you have ever had a seizure before starting treatment.
Heart and Circulation Problems
Tell your healthcare provider if you have heart disease, cerebrovascular disease, low blood pressure, or another condition that may make you more sensitive to changes in blood pressure.
Your healthcare provider may monitor you more closely during treatment.
Liver or Kidney Problems
Tell your healthcare provider if you have liver or kidney problems.
Olanzapine is mainly processed by the liver. Kidney impairment does not usually require a dose adjustment, but your healthcare provider will consider your overall health when deciding on the most appropriate dose.
Elderly Adults With Dementia-Related Psychosis
Zyprexa Zydis is not approved to treat dementia-related psychosis.
Older adults with dementia-related psychosis who take antipsychotic medications have an increased risk of death.
Olanzapine has also been associated with a higher risk of cerebrovascular events, including stroke and transient ischemic attack (TIA), in this population.
Changes in Mood or Suicidal Thoughts
People with schizophrenia or bipolar disorder may experience depression, suicidal thoughts, or changes in behaviour as part of their underlying condition.
Tell your healthcare provider right away if you notice:
- New or worsening depression
- Thoughts of self-harm or suicide
- Major changes in mood or behaviour
- Unusual agitation or impulsive behaviour
Seek immediate help if you are in danger of harming yourself or someone else.
When to Contact Your Healthcare Provider
Contact your healthcare provider if you develop severe drowsiness, fainting, uncontrolled movements, significant weight gain, high blood sugar symptoms, or any new or worsening symptoms while taking Zyprexa Zydis.
Do not stop taking Zyprexa Zydis or change your dose without speaking with your healthcare provider.
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