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Pristiq is a prescription medication indicated for the treatment of major depressive disorder (MDD) in adults. Pristiq contains an active ingredient called desvenlafaxine. Desvenlafaxine is an antidepressant belonging to a group of drugs called selective serotonin and norepinephrine reuptake inhibitors (SNRIs). Pristiq works by preventing the reuptake of two neurotransmitters, serotonin, and norepinephrine, which can help improve mood.

Pristiq is a prescription medicine used to treat depression and anxiety in adults. It should only be used as directed by a healthcare professional, and patients should always consult with their doctor before starting or stopping any medication. Desvenlafaxine is known to help improve mood, feelings of well-being, and energy levels.

Uses and Dosage

Pristiq comes in tablet form and is taken orally with or without food as directed by a doctor, usually once a day. Do not crush, chew, or dissolve the tablets, as this can release all the drugs at once and increase the risk of side effects. Follow the doctor's instructions carefully and do not increase the dose or use Pristiq more often or for longer than prescribed. Regular use of Pristiq is necessary to obtain the maximum benefit, and patients should take it at the same time each day to help them remember to take it.

The recommended dosage of Pristiq is 50 mg once daily, with or without food. The doses of 50-100 mg/day were shown to be effective, but there was no evidence that doses greater than 50 mg per day confer any additional benefit. Follow a doctor's instructions carefully and do not increase the dose or use Pristiq more often or for longer than prescribed.

Side Effects

Common Side Effects of Pristiq (Desvenlafaxine):

  • Constipation
  • Dizziness
  • Drowsiness
  • Dry mouth
  • Increased sweating
  • Insomnia or trouble sleeping
  • Loss of appetite
  • Nausea
  • Nervousness
  • Weight loss

Serious Side Effects of Pristiq (Desvenlafaxine)

  • Bleeding
  • Chest pain
  • Eye swelling
  • High blood sugar or hypertension
  • Impotence
  • Low sex drive
  • Persistent cough
  • Severe pounding headache
  • Shortness of breath
  • Signs of serotonin syndrome (palpitations, hallucinations, loss of coordination, agitation, severe nausea, vomiting, twitching of muscles, unexplained fever)
  • Tremors
  • Vision changes
  • Widened pupils

Form and Strength

Pristiq (Desvenlafaxine) is available in the following forms and strengths:

Pristiq: Extended-Release Tablet

  • 25mg
  • 50mg
  • 100mg

Desvenlafaxine: Extended-Release Tablet

  • 25mg
  • 50mg
  • 100mg


  • Pristiq should not be used within 7 days before or 14 days after the use of an MAO inhibitor, including isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.
  • Consult with your doctor before stopping the use of Pristiq or any other medication. Sudden withdrawal from Pristiq can cause withdrawal symptoms and may lead to a worsening of the underlying condition.
  • People with depression or mental illness may experience suicidal thoughts, especially when starting treatment with medication. Contact your doctor immediately if you have sudden changes in mood or behavior or suicidal thoughts.
  • If you are allergic to desvenlafaxine or venlafaxine, which are active ingredients in Pristiq and other medications, you should not take Pristiq. Inform your doctor about any allergies or adverse reactions you may have to any medications before starting a new treatment.
  • May increase risk of bleeding, particularly when taken with other medications that affect blood clotting.
  • May increase blood pressure and heart rate.
  • May cause serotonin syndrome if taken with other medications that affect serotonin levels.
  • Caution in patients with liver or kidney disease
  • Caution in elderly patients or those with a history of glaucoma, seizures, or high blood pressure.

Frequently Asked Questions (FAQ)

How long does it take for Desvenlafaxine to work?

It can take several weeks for Desvenlafaxine to begin to work.

Can desvenlafaxine be taken with other medications?

Inform your doctor or pharmacist about any other medications you are taking, as some medications may interact with desvenlafaxine.

Is it safe to drink alcohol while taking desvenlafaxine?

It is generally recommended to avoid excessive alcohol consumption while taking desvenlafaxine.

Can desvenlafaxine be used during pregnancy or while breastfeeding?

Discuss the risks and benefits of using desvenlafaxine during pregnancy or while breastfeeding with your healthcare provider.

What should I do if I miss a dose of desvenlafaxine?

Take the missed dose as soon as you remember, but do not take a double dose to make up for a missed one.


Additional information

Generic name:



Extended Release Tablet


25mg, 50mg, 100mg

Quantities Available:

28, 30, 84, 90, 100


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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Pristiq (Desvenlafaxine). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Pristiq (Desvenlafaxine).