Indications
Parnate is a prescription drug used to treat major depressive disorder (MDD) in adults who have not responded adequately to other antidepressants. It can be used to treat depression by restoring the balance of natural substances (neurotransmitters) in the brain. Parnate is generically known as Tranylcypromine.
Tranylcypromine is a monoamine oxidase inhibitor (MAOI) that increases the levels of certain chemicals in the brain, such as dopamine, norepinephrine, and serotonin, which are involved in regulating mood. By inhibiting the action of monoamine oxidase, an enzyme that breaks down these chemicals, Parnate helps to restore their normal balance in the brain, improving the symptoms of depression.
Uses and Dosage
Parnate is available in tablet form and is taken orally, usually in divided doses or as directed by your doctor. Parnate can be taken with or without food. To minimize the risk of side effects, your doctor may recommend starting with a low dose and gradually increasing it. Once you start getting better, and your condition improves, your doctor may adjust your regular dose, and you must follow their instructions carefully. Avoid stopping or changing the medication without first consulting your doctor. Do not take more or less medication, or take it more frequently, than prescribed.
The dosage is determined based on your response to therapy and medical condition. However, typical dosing is 30 mg by mouth daily, in divided doses. The maximum dose is 30 mg twice daily, but it does not exceed 60 milligrams per day.
Side Effects
Common Side Effects of Parnate (Tranylcypromine):
- Blurry vision
- Constipation
- Dizziness
- Drowsiness
- Dry mouth
- Blurred vision
- Feeling shaky or excited
- Headache
- Overexcitement
- Sleepiness
- Tremor
- Shakiness
- Trouble sleeping
Serious Side Effects of Parnate (Tranylcypromine):
- Anxiety
- Bladder problems
- Double vision
- Fast heartbeat
- Fluid retention or bloating
- Loss of appetite or anorexia
- Poor coordination
- Ringing in the ear
- Sexual dysfunction
- Weight gain
Form and Strength
Parnate (Tranylcypromine) is available in the following forms and strength:
Parnate: Tablet
- 10 mg
Caution
- Interactions with certain foods and medications, including over-the-counter cough and cold medicines, can cause serious side effects such as high blood pressure and hypertensive crisis.
- Suicide risk: Parnate may increase the risk of suicidal thoughts and actions in some people, particularly in the early stages of treatment or when the dosage is adjusted.
- Serotonin syndrome: Parnate can cause a potentially life-threatening condition called serotonin syndrome when taken with certain other medications, particularly antidepressants such as selective serotonin reuptake inhibitors (SSRIs).
- Hypertensive crisis: Parnate can cause a sudden, severe increase in blood pressure (hypertensive crisis) if taken with certain foods or medications or if the dosage is too high.
- Contraindicated in certain medical conditions, such as liver disease, uncontrolled high blood pressure, or a history of heart disease or stroke.
- Used with caution in elderly patients, as they may be more sensitive to the effects of the medication and more prone to side effects such as falls or confusion.
- Parnate is not recommended during pregnancy or breastfeeding without medical advice.
Frequently Asked Questions (FAQ)
How long does it take for Parnate to start working?
Parnate can take several weeks to start working for depression. Continue taking the medication as prescribed and communicate with your doctor about any concerns or lack of improvement.
Can Parnate be used to treat other conditions besides depression?
While Parnate is primarily used to treat depression, it may also be used to treat other conditions such as panic disorder, social anxiety disorder, and bulimia nervosa.
Is Parnate safe for everyone to take?
No, Parnate is not safe for everyone to take. It should not be taken by individuals who have a history of heart disease, liver disease, or a history of stroke. It should also not be taken by anyone who is currently taking certain other medications or substances, such as certain narcotics or decongestants.
What should I do if I miss a dose of Parnate?
If you miss a dose of Parnate, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Is it safe to take Parnate while pregnant or breastfeeding?
The safety of Parnate during pregnancy or while breastfeeding has not been established. Discuss the potential risks and benefits with your doctor before taking Parnate if you are pregnant or breastfeeding.
Resources
- https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b72d8187-dfcc-4ea0-b5e9-c0be95b69a27
- https://www.drugs.com/mtm/parnate.html
- https://www.goodrx.com/tranylcypromine/what-is
- https://www.webmd.com/drugs/2/drug-6965/parnate-oral/details
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/012342s064lbl.pdf
REVIEWS