Emsam Patch (Selegiline)

Indications

Emsam is a transdermal patch that contains selegiline, a monoamine oxidase inhibitor (MAOI) used for the treatment of major depressive disorder in adults and adolescents who are at least 12 years old. Emsam works by blocking the activity of monoamine oxidase, an enzyme that breaks down serotonin, dopamine, and norepinephrine in the brain. By blocking the breakdown of these neurotransmitters.

Emsam should not be used with certain medications, including selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, and certain pain medications called meperidine-like drugs. Emsam can help to increase their levels in the brain, which can improve symptoms of depression.

Uses and Dosage

Emsam patch is applied to clean, dry skin on the upper body (torso), upper thigh or on the outside of the upper arm. The patch is left on for 24 hours and is replaced with a new patch every day. To use the Emsam patch, follow the instructions provided by your healthcare provider and the information on the prescription label.

Remove the old patch before applying a new one, as only one patch should be worn at a time. You should also choose a new area of skin each day to apply the patch to prevent skin irritation. Use the Emsam patch exactly as prescribed by your healthcare provider. Do not use more or less of it or use it more, or less, often than recommended. It may take some time for the patch to start working and continue using it as directed even if you do not see immediate improvement in your symptoms.

To start treatment with selegiline (Emsam), a typical starting dose is a 6 mg patch applied to the skin once every 24 hours. The maximum dose for Emsam is 12 mg every 24 hours.

Side effect

Common Side Effects of Emsam Patch (Selegiline):

• Diarrhea
• Difficulty falling or staying asleep
• Dry mouth
• Headache
• Painful swelling near the throat
• Rash
• Skin irritations under or near the patch
• Stomach upset
• Swelling or infections in the sinuses

Serious Side Effects of Emsam Patch (Selegiline):

• Low blood pressure
• Sexual dysfunction
• Weight gain
• Weight loss

Form and Strength

Emsam Patch (Selegiline) is available in the following forms and strength:

Emsam Patch: Patch

• 6 mg
• 12 mg

Caution

• Suicidal thoughts or behaviors
• Dangerously high blood pressure and Serotonin syndrome
• Transient hypertension when consuming certain foods that contain tyramine or other pressor amines or when taking other medications that interact with Emsam.
• Contraindicated with certain medications, including selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, and certain pain medications called meperidine-like drugs.
• May interact with other medications, including prescription and over-the-counter medications, as well as herbal supplements.
• May affect motor skills and mental alertness, especially when used with other medications that have sedative properties.
• May cause dizziness or fainting.
• Increased risk of serotonin syndrome when used with other serotonergic medications.
• Caution should be exercised in patients with certain medical conditions such as liver disease, renal impairment, cardiovascular disease, and seizure disorders.
• Increased risk of adverse events in elderly patients
• May interact with alcohol or illicit drugs.
• May not be safe for use during pregnancy or breastfeeding.
• May cause skin irritation at the patch site.

Frequently Asked Questions (FAQ)

What foods should I avoid while using Emsam Patch?

While using Emsam Patch, you should avoid foods containing elevated levels of tyramine, such as aged cheeses, cured meats, and some types of beer and wine. Consumption of tyramine with Emsam can lead to dangerously high blood pressure.

Can I use Emsam Patch if I am pregnant or breastfeeding?

Emsam Patch is not recommended for use during pregnancy or breastfeeding. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your healthcare provider about the risks and benefits of using Emsam Patch.

What should I do if I miss a dose of Emsam Patch?

If you miss a dose of Emsam Patch, apply a new patch as soon as possible, and then continue your regular dosing schedule. Do not apply two patches at the same time to make up for a missed dose.

Can Emsam Patch be used with other medications?

Emsam Patch should not be taken with certain other medications, including other MAO inhibitors, meperidine, and certain stimulants. Inform your healthcare provider about all medications you are currently taking before using Emsam Patch.

Resources

• https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=b891bd9f-fdb8-4862-89c5-ecdd700398a3
• https://www.goodrx.com/emsam/what-is
• https://www.webmd.com/drugs/2/drug-95354/emsam-transdermal/details
• https://online.lexi.com/lco/medguides/611376.pdf
• https://reviews.webmd.com/drugs/drugreview-95354-emsam-transdermal
• https://www.drugs.com/emsam.html